Hsa_circ_0006969 aggravates keratinocytes from high-glucose injury by sponging miR-375 to promote USP10 and SCD expression

Bhuiyan MU et al (2019) Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children. BMC Pulm Med 19(1):71

Article  PubMed  PubMed Central  Google Scholar 

Chen CI et al (2021) Utility of RGNEF in the Prediction of Clinical Prognosis in Patients with Rectal Cancer Receiving Preoperative Concurrent Chemoradiotherapy. Life (Basel) 12(1), 18

Chen H et al (2026) FGFR2 is a Candidate Immune-Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways. Mediators Inflamm 2026(1):e3260549

Article  PubMed  PubMed Central  Google Scholar 

Cheng X et al (2022) The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis. Cell Death Dis 13(3):207

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dai D et al (2020) Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma. Med (Baltim) 99(32):e21478

Article  CAS  Google Scholar 

Feng X et al (2022) Weighted Gene Co-expression Network Analysis Revealed That CircMARK3 Is a Potential CircRNA Affects Fat Deposition in Buffalo. Front Vet Sci 9:946447

Article  PubMed  PubMed Central  Google Scholar 

Fu Z et al (2023) Upregulation of circ_0080968 in diabetic foot ulcer inhibits wound healing via repressing the migration and promoting proliferation of keratinocytes. Gene 883:147669

Article  PubMed  CAS  Google Scholar 

Garcia-Jacobo RE et al (2019) Circulating miR-146a, miR-34a and miR-375 in type 2 diabetes patients, pre-diabetic and normal-glycaemic individuals in relation to beta-cell function, insulin resistance and metabolic parameters. Clin Exp Pharmacol Physiol 46(12):1092–1100

Article  PubMed  CAS  Google Scholar 

Ghafourian AR et al (2026) Circular RNAs in Diabetic Foot Ulcers: A Scoping Review of Clinical, Preclinical, and In Silico Evidence on Diagnostic and Therapeutic Potentials. Endocrinol Diabetes Metab 9(1):e70155

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han D et al (2017) Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology 66(4):1151–1164

Article  PubMed  CAS  Google Scholar 

Han D et al (2021) Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31/FBN1 axis. J Mol Histol 52(4):681–691

Article  PubMed  CAS  Google Scholar 

He Z, Xu X (2022) Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p/FOXO4 Axis. Biochem Genet 60(4):1236–1252

Article  PubMed  CAS  Google Scholar 

Higuchi C et al (2015) Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes. Metabolism 64(4):489–497

Article  PubMed  CAS  Google Scholar 

Hu W et al (2019) Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-beta1. J Cell Physiol 234(2):1469–1476

Article  PubMed  CAS  Google Scholar 

Kleinschmidt EG et al (2019) Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene 38(36):6323–6337

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee J et al (2026) Rgnef regulates bone mass through the activation of RhoA and Rac1. Exp Mol Med 58(1):243–253

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li M et al (2021) WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs. Int J Gen Med 14:8737–8751

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li D et al (2022) The progress and challenges of circRNA for diabetic foot ulcers: A mini-review. Front Endocrinol (Lausanne) 13:1019935

Article  PubMed  PubMed Central  Google Scholar 

Li CM et al (2025) Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction. Kaohsiung J Med Sci 41(9):e70047

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liew CF et al (2004) Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia 47(12):2168–2175

Article  PubMed  CAS  Google Scholar 

Liu X et al (2020) Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration. Curr Eye Res 45(9):1173–1180

Article  PubMed  CAS  Google Scholar 

Liu L et al (2021) Isoquercitrin protects HUVECs against high glucoseinduced apoptosis through regulating p53 proteasomal degradation. Int J Mol Med 48(1), 122

Liu P et al (2022) The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition. Mol Cancer 21(1):198

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ochoa-Gonzalez F et al (2016) Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. PLoS ONE 11(3):e0150900

Article  PubMed  PubMed Central  Google Scholar 

Pu LJ et al (2020) Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats. Eur Rev Med Pharmacol Sci 24(5):2189–2195

PubMed  Google Scholar 

Qu S et al (2015) Circular RNA: A new star of noncoding RNAs. Cancer Lett 365(2):141–148

Article  PubMed  CAS  Google Scholar 

Qu H et al (2021) Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing. Diabetes 70(5):1170–1184

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sugiwaki H et al (2023) Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1. J Cosmet Dermatol

Sun X et al (2020) Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway. Acta Histochem 122(8):151649

Article  PubMed  CAS  Google Scholar 

Tian M et al (2021) Identification of potential circRNAs and circRNA-miRNA-mRNA regulatory network in the development of diabetic foot ulcers by integrated bioinformatics analysis. Int Wound J 18(3):323–331

Article  PubMed  Google Scholar 

Wang J et al (2005) Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun 332(3):735–742

Article  PubMed  CAS  Google Scholar 

Wang W et al (2015) TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits Genotoxic Nuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem 290(21):13372–13385

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang A et al (2020) Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. Adv Wound Care (New Rochelle) 9(4):145–160

Article  PubMed  PubMed Central  Google Scholar 

Wang Y et al (2023) Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs. BMC Genomics 24(1):477

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