Bai Y, Pan Y, Liu X (2025) Mechanistic insights into gasdermin-mediated pyroptosis. Nat Rev Mol Cell Biol 26(7):501–521

Article  PubMed  CAS  Google Scholar 

Burdette BE, Esparza AN, Zhu H, Wang S (2021) Gasdermin D in pyroptosis. Acta Pharm Sinica B 11(9):2768–2782

Article  CAS  Google Scholar 

Chen Y, Wei G, Feng X, Lei E, Zhang L (2024) Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat. Exp Neurol 379:114842

Article  PubMed  CAS  Google Scholar 

Cheng B, He Q, Ge D, Ma S, Luo Y, Wang J (2026) Electroacupuncture mitigates cognitive impairment caused by anesthesia and surgery in aged rats by inhibiting the p38 MAPK signaling pathway. Neurotoxicol Teratol 115:107602

Article  PubMed  CAS  Google Scholar 

Ding J, Zhang K, Wang D, Wang Q (2024) Sevoflurane augments neuroinflammation by regulating DUSP6 via YTHDF1 in postoperative cognitive dysfunction. Toxicol Res 13(4):tfae100

Article  CAS  Google Scholar 

Feng Y, Li M, Yangzhong X, Zhang X, Zu A, Hou Y, Li L, Sun S (2022) Pyroptosis in inflammation-related respiratory disease. J Physiol Biochem 78(4):721–737

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han B, Jin F, Zhong Y, Teng J (2026) Esketamine ameliorates postoperative cognitive dysfunction aggravated by preoperative acute sleep deprivation in aged mice via the TLR4/NF-kappaB pathway. Front Aging Neurosci 18:1798915

Article  PubMed  PubMed Central  Google Scholar 

Hao W, Feng C (2023) Research progress on pyroptosis and its effect on the central nervous system. Neurobiol Dis 106333

Huang L, Zheng C, He C, Qiu X, Wei H, Yan J, Cui K, Yang W, Yao L, Wei Y et al (2026) USF1 transcriptionally activates TRIM55 to promote diabetic cardiomyopathy progression by enhancing HSPB1 protein degradation. J Bioenerg Biomembr 58(1):7

Article  PubMed  CAS  Google Scholar 

Jiang W, Fan X, Wu H, Song J, Yang C, Zhao Z (2025) TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells. Neurotoxicol Teratol 110:107500

Article  PubMed  CAS  Google Scholar 

Kim C, Wang XD, Jang S, Yu Y (2023) PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage. Biochem Biophys Res Commun 646:78–85

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li P, Wang H, Hou M, Li D, Bai H (2017) Upstream stimulating factor1 (USF1) enhances the proliferation of glioblastoma stem cells mainly by activating the transcription of mucin13 (MUC13). Pharmazie 72(2):98–102

Article  PubMed  CAS  Google Scholar 

Lin X, Chen Y, Zhang P, Chen G, Zhou Y, Yu X (2020) The potential mechanism of postoperative cognitive dysfunction in older people. Exp Gerontol 130:110791

Article  PubMed  CAS  Google Scholar 

Lin QC, Wang J, Wang XL, Pan C, Jin SW, Char S, Tao YX, Cao H, Li J (2024) Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice. Biochim et Biophys acta Mol basis disease 1870(5):167137

Article  CAS  Google Scholar 

Lin X, Luo Y, Zhu Q (2026) Postoperative cognitive dysfunction and neurodegeneration: From inflammation to precision medicine. Brain Res Bull 237:111776

Article  PubMed  CAS  Google Scholar 

Lu J, Liu Z, Zhao Y, Liu X, He W, Zhang L (2023) FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1alpha/BDNF/FNDC5 pathway. Tissue Cell 81:102012

Article  PubMed  CAS  Google Scholar 

Ma H, Zhu Y, Zhao X, Jiang L, Yang J, Yang T, Liu W (2025) Pyroptosis: inflammatory cell death mechanism and its pathological roles in neurological diseases and injuries. Apoptosis: Int J Program cell death 30(9–10):2057–2076

Article  CAS  Google Scholar 

Mamun AA, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J (2021) Role of Pyroptosis in Diabetes and Its Therapeutic Implications. J Inflamm Res 14:2187–2206

Article  PubMed  PubMed Central  Google Scholar 

Moujalled D, Strasser A, Liddell JR (2021) Molecular mechanisms of cell death in neurological diseases. Cell Death Differ 28(7):2029–2044

Article  PubMed  PubMed Central  Google Scholar 

Oladapo A, Jackson T, Menolascino J, Periyasamy P (2024) Role of pyroptosis in the pathogenesis of various neurological diseases. Brain Behav Immun 117:428–446

Article  PubMed  PubMed Central  CAS  Google Scholar 

Paldino E, D’Angelo V, Laurenti D, Angeloni C, Sancesario G, Fusco FR (2020) Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington’s Disease. Cells 9(10):2286

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peng W, Lu W, Jiang X, Xiong C, Chai H, Cai L, Lan Z (2023) Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update. Curr Mol Med 23(10):1077–1086

Article  PubMed  CAS  Google Scholar 

Qin J, Ma Q, Ma D (2020) Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway. Curr Neurovasc Res 17(3):232–240

Article  PubMed  CAS  Google Scholar 

Sahu P, Satapathy A, Satapathy A, Satapathy T (2025) Single-cell multi-omics for biomarker discovery: Technologies, molecular mechanisms, applications and translational challenges. Lett Drug Des Discovery 22(12):100286

Article  Google Scholar 

Su W, Xie M, Li Y, Gong X, Li J (2020) Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromol Med 22(2):227–238

Article  CAS  Google Scholar 

Sun J, Du X, Chen Y (2024) Current Progress on Postoperative Cognitive Dysfunction: An Update. J Integr Neurosci 23(12):224

Article  PubMed  Google Scholar 

Sun H, Cai R, Zhao M, Shan Y, Ma K, Qian M (2025) Beyond apoptosis: Exploring necroptosis, ferroptosis, and pyroptosis in sevoflurane- and isoflurane-associated PNDs. IBRO Neurosci Rep 19:688–698

Article  PubMed  PubMed Central  CAS  Google Scholar 

Suo Z, Xiao T, Qu Y, Zheng Y, Xu W, Zhou B, Yang J, Yu J, Zheng H, Ni C (2025) Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment. Aging Cell 24(3):e14406

Article  PubMed  CAS  Google Scholar 

Suraarunsumrit P, Srinonprasert V, Kongmalai T, Suratewat S, Chaikledkaew U, Rattanasiri S, McKay G, Attia J, Thakkinstian A (2024) Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis. Age Ageing 53(7):afae160

Article  PubMed  PubMed Central  Google Scholar 

Varpaei HA, Farhadi K, Mohammadi M, Khafaee Pour Khamseh A, Mokhtari T (2024) Postoperative cognitive dysfunction: a concept analysis. Aging Clin Exp Res 36(1):133

Article  PubMed  PubMed Central  Google Scholar 

Wang B, Zhu C, Zhang N, Li L, Sun L, Xu J (2018) Nampt/RelB pathway protects learning and memory ability in aged rats after general anesthesia with sevoflurane and nitrous oxide. Int J Clin Exp Pathol 11(1):293–303

PubMed  PubMed Central  Google Scholar 

Wang CM, Chen WC, Zhang Y, Lin S, He HF (2021) Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction. Front Aging Neurosci 13:702231

Article  PubMed  PubMed Central  CAS