LECT2–RPS27A interaction involving Lys48 attenuates neuroinflammation in diabetic retinopathy

Yau JW, Rogers SL, Kawasaki R et al (2012) Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35(3):556–564. https://doi.org/10.2337/dc11-1909

Article  PubMed  PubMed Central  Google Scholar 

Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376(9735):124–136. https://doi.org/10.1016/S0140-6736(09)62124-3

Article  PubMed  Google Scholar 

Wong TY, Cheung CM, Larsen M, Sharma S, Simo R (2016) Diabetic retinopathy. Nat Rev Dis Primers 2:16012. https://doi.org/10.1038/nrdp.2016.12

Article  PubMed  Google Scholar 

Schmidt-Erfurth U, Garcia-Arumi J, Bandello F et al (2017) Guidelines for the management of diabetic macular edema by the European Society of Retina Specialists (EURETINA). Ophthalmologica 237(4):185–222. https://doi.org/10.1159/000458539

Article  PubMed  Google Scholar 

Stark AK, Penn JS (2024) Prostanoid signaling in retinal cells elicits inflammatory responses relevant to early-stage diabetic retinopathy. J Neuroinflammation 21(1):329. https://doi.org/10.1186/s12974-024-03319-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang J, Kern TS (2011) Inflammation in diabetic retinopathy. Prog Retin Eye Res 30(5):343–358. https://doi.org/10.1016/j.preteyeres.2011.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonetti DA, Silva PS, Stitt AW (2021) Current understanding of the molecular and cellular pathology of diabetic retinopathy. Nat Rev Endocrinol 17(4):195–206. https://doi.org/10.1038/s41574-020-00451-4

Article  PubMed  PubMed Central  Google Scholar 

Ngcobo NN, Sibiya NH (2024) The role of high mobility group box-1 on the development of diabetes complications: a plausible pharmacological target. Diab Vasc Dis Res 21(5):14791641241271948. https://doi.org/10.1177/14791641241271949

Article  PubMed  PubMed Central  Google Scholar 

Mesquida M, Drawnel F, Fauser S (2019) The role of inflammation in diabetic eye disease. Semin Immunopathol 41(4):427–445. https://doi.org/10.1007/s00281-019-00750-7

Article  PubMed  Google Scholar 

Rubsam A, Parikh S, Fort PE (2018) Role of inflammation in diabetic retinopathy. Int J Mol Sci 19(4):942. https://doi.org/10.3390/ijms19040942

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Wang S, Xia X (2012) Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. Curr Eye Res 37(5):416–420. https://doi.org/10.3109/02713683.2012.661114

Article  CAS  PubMed  Google Scholar 

Dorweiler TF, Singh A, Ganju A et al (2024) Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy. Cell Metab 36(7):1521-1533 e1525. https://doi.org/10.1016/j.cmet.2024.04.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv K, Ying H, Hu G, Hu J, Jian Q, Zhang F (2022) Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy. Front Immunol 13:942768. https://doi.org/10.3389/fimmu.2022.942768

Article  CAS  PubMed  PubMed Central  Google Scholar 

Titchenell PM, Antonetti DA (2013) Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy. Diabetes 62(6):1808–1815. https://doi.org/10.2337/db12-1744

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos AR, Costa MA, Schwartz C et al (2018) Optical coherence tomography baseline predictors for initial best-corrected visual acuity response to intravitreal anti-vascular endothelial growth factor treatment in eyes with diabetic macular edema: the Chartres study. Retina 38(6):1110–1119. https://doi.org/10.1097/IAE.0000000000001687

Article  CAS  PubMed  Google Scholar 

Bressler NM, Beaulieu WT, Maguire MG et al (2018) Early response to anti-vascular endothelial growth factor and two-year outcomes among eyes with diabetic macular edema in protocol T. Am J Ophthalmol 195:93–100. https://doi.org/10.1016/j.ajo.2018.07.030

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez VH, Campbell J, Holekamp NM et al (2016) Early and long-term responses to anti-vascular endothelial growth factor therapy in diabetic macular edema: analysis of protocol I data. Am J Ophthalmol 172:72–79. https://doi.org/10.1016/j.ajo.2016.09.012

Article  CAS  PubMed  Google Scholar 

Lai D, Wu Y, Shao C, Qiu Q (2023) The role of muller cells in diabetic macular edema. Invest Ophthalmol Vis Sci 64(10):8. https://doi.org/10.1167/iovs.64.10.8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carpi-Santos R, de Melo Reis RA, Gomes FCA, Calaza KC (2022) Contribution of Muller cells in the diabetic retinopathy development: focus on oxidative stress and inflammation. Antioxidants (Basel) 11(4):617. https://doi.org/10.3390/antiox11040617

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Xu X, Elliott MH, Zhu M, Le YZ (2010) Muller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes 59(9):2297–2305. https://doi.org/10.2337/db09-1420

Article  CAS  PubMed  PubMed Central  Google Scholar 

Portillo JC, Lopez Corcino Y, Miao Y et al (2017) CD40 in retinal muller cells induces P2X7-dependent cytokine expression in macrophages/microglia in diabetic mice and development of early experimental diabetic retinopathy. Diabetes 66(2):483–493. https://doi.org/10.2337/db16-0051

Article  CAS  PubMed  Google Scholar 

Abcouwer SF (2017) Muller cell-microglia cross talk drives neuroinflammation in diabetic retinopathy. Diabetes 66(2):261–263. https://doi.org/10.2337/dbi16-0047

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lao J, Zhu H, You Q, Nie M, Lal Pathak J (2024) Updates on the role of leukocyte cell-derived chemotaxin-2 in inflammation regulation and immunomodulation. Cytokine 181:156697. https://doi.org/10.1016/j.cyto.2024.156697

Article  CAS  PubMed  Google Scholar 

Lu XJ, Chen Q, Rong YJ et al (2016) LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun 7:12719. https://doi.org/10.1038/ncomms12719

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolf J, Rasmussen DK, Sun YJ et al (2023) Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo. Cell 186(22):4868-4884 e4812. https://doi.org/10.1016/j.cell.2023.09.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin YJ, Xiao K, Zhong Z, Zhao Y, Yu T, Sun XF (2022) LECT2 ameliorates blood-retinal barrier impairment secondary to diabetes via activation of the Tie2/Akt/mTOR signaling pathway. Invest Ophthalmol Vis Sci 63(3):7. https://doi.org/10.1167/iovs.63.3.7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voss H, Schlumbohm S, Barwikowski P et al (2022) HarmonizR enables data harmonization across independent proteomic datasets with appropriate handling of missing values. Nat Commun 13(1):3523. https://doi.org/10.1038/s41467-022-31007-x

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