Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives

Ahmed FF, Abd El-Hafeez AA, Abbas SH et al (2018) New 1,2,4-triazole-chalcone hybrids induce caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells. Eur J Med Chem 151:705–722. https://doi.org/10.1016/j.ejmech.2018.03.073

Article  CAS  PubMed  Google Scholar 

An X, Yu W, Liu J et al (2024) Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis 15:556. https://doi.org/10.1038/s41419-024-06939-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashraf R, Hamidullah, Hasanain M et al (2017) Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications. Sci Rep 7:45287. https://doi.org/10.1038/srep45287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bagul C, Rao GK, Makani VKK et al (2017) Synthesis and biological evaluation of chalcone-linked pyrazolo[1,5-a]pyrimidines as potential anticancer agents. Medchemcomm 8:1810–1816. https://doi.org/10.1039/c7md00193b

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basak P, Sadhukhan P, Sarkar P, Sil PC (2017) Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy. Toxicol Rep 4:306–318. https://doi.org/10.1016/j.toxrep.2017.06.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blagosklonny MV (2023) Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells. Oncotarget 14:193–206. https://doi.org/10.18632/oncotarget.28382

Article  PubMed  PubMed Central  Google Scholar 

Bocci F, Tripathi SC, Vilchez Mercedes SA et al (2019) NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype. Integr Biol (Camb) 11:251–263. https://doi.org/10.1093/intbio/zyz021

Article  PubMed  PubMed Central  Google Scholar 

Bukhari SNA, Jasamai M, Jantan I (2012) Synthesis and biological evaluation of chalcone derivatives (mini review). Mini Rev Med Chem 12:1394–1403. https://doi.org/10.2174/13895575112091394

Article  CAS  PubMed  Google Scholar 

Burmaoglu S, Gobek A, Aydin BO et al (2021) Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents. Bioorg Chem 111:104882. https://doi.org/10.1016/j.bioorg.2021.104882

Article  CAS  PubMed  Google Scholar 

Cao J, Wang C, Hao N et al (2022) Endoplasmic reticulum stress and reactive oxygen species in plants. Antioxidants (Basel) 11:1240. https://doi.org/10.3390/antiox11071240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castiglioni S, Cammarano F, Plasmati C et al (2022) Multi-modality treatment of locally advanced lung cancer: a focus on radiotherapy. Curr Challenges Thorac Surg. https://doi.org/10.21037/ccts-20-72

Article  Google Scholar 

Çavuşoğlu BK, Atlı Ö, Görmüş G et al (2018) Synthesis and evaluation of heterocycles based chalcone derivatives as antiproliferative agents. Anticancer Agents Med Chem 18:1044–1053. https://doi.org/10.2174/1871520618666180105163657

Article  CAS  PubMed  Google Scholar 

Cheah S-C, Appleton DR, Lee S-T et al (2011) Panduratin A inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-kappaB translocation. Molecules 16:2583–2598. https://doi.org/10.3390/molecules16032583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Shenoy AK, Padia R et al (2018) Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2’, 4’-Tetrahydroxychalcone. J Exp Clin Cancer Res 37:243. https://doi.org/10.1186/s13046-018-0902-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen G, Zhou D, Li X-Z et al (2017) A natural chalcone induces apoptosis in lung cancer cells: 3D-QSAR, docking and an in vivo/vitro assay. Sci Rep 7:10729. https://doi.org/10.1038/s41598-017-11369-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheung EC, Vousden KH (2022) The role of ROS in tumour development and progression. Nat Rev Cancer 22:280–297. https://doi.org/10.1038/s41568-021-00435-0

Article  CAS  PubMed  Google Scholar 

Chouiter MI, Boulebd H, Pereira DM et al (2020) New chalcone-type compounds and 2-pyrazoline derivatives: synthesis and caspase-dependent anticancer activity. Future Med Chem 12:493–509. https://doi.org/10.4155/fmc-2019-0342

Article  CAS  PubMed  Google Scholar 

Consoli V, Sorrenti V, Grosso S, Vanella L (2021) Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions. Biomolecules 11:589. https://doi.org/10.3390/biom11040589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coskun D, Erkisa M, Ulukaya E et al (2017) Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity. Eur J Med Chem 136:212–222. https://doi.org/10.1016/j.ejmech.2017.05.017

Article  CAS  PubMed  Google Scholar 

Dao TTH, Linthorst HJM, Verpoorte R (2011) Chalcone synthase and its functions in plant resistance. Phytochem Rev 10:397–412. https://doi.org/10.1007/s11101-011-9211-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di S, Fan C, Ma Z et al (2019) PERK/eIF-2α/CHOP pathway dependent ROS generation mediates butein-induced non-small-cell lung cancer apoptosis and G2/M phase arrest. Int J Biol Sci 15:1637–1653. https://doi.org/10.7150/ijbs.33790

Article  CAS  PubMed  PubMed Central  Google Scholar 

Disbrow GL, Hanover JA, Schlegel R (2005) Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH. J Virol 79:5839–5846. https://doi.org/10.1128/JVI.79.9.5839-5846.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong N, Liu X, Zhao T et al (2018) Apoptosis-inducing effects and growth inhibitory of a novel chalcone, in human hepatic cancer cells and lung cancer cells. Biomed Pharmacother 105:195–203. https://doi.org/10.1016/j.biopha.2018.05.126

Article  CAS  PubMed  Google Scholar 

Eichenbaum G, Johnson M, Kirkland D et al (2009) Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product. Regul Toxicol Pharmacol 55:33–42. https://doi.org/10.1016/j.yrtph.2009.05.018

Article  CAS  PubMed  Google Scholar 

El-Wakil MH, Khattab SN, El-Yazbi AF et al (2020) New chalcone-tethered 1,3,5-triazines potentiate the anticancer effect of cisplatin against human lung adenocarcinoma A549 cells by enhancing DNA damage and cell apoptosis. Bioorg Chem 105:104393. https://doi.org/10.1016/j.bioorg.2020.104393

Article  CAS  PubMed  Google Scholar 

Erturk E, Onur OE, Aydin I et al (2023) Targeting the epithelial-mesenchymal transition (EMT) pathway with combination of Wnt inhibitor and chalcone complexes in lung cancer cells. J Cell Biochem 124:1203–1219. https://doi.org/10.1002/jcb.30442

Article  CAS  PubMed  Google Scholar 

Fan X, Guan G, Wang J et al (2023) Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer. Oncol Rep 50:214. https://doi.org/10.3892/or.2023.8651

Article  CAS 

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