Andreadou I, Ghigo A, Nikolaou P-E, Swirski FK, Thackeray JT, Heusch G, Vilahur G (2025) Immunometabolism in heart failure. Nat Rev Cardiol 22:751–772. https://doi.org/10.1038/s41569-025-01165-8
Barefield D, Sadayappan S (2010) Phosphorylation and function of cardiac myosin binding protein-C in health and disease. J Mol Cell Cardiol 48:866–875. https://doi.org/10.1016/j.yjmcc.2009.11.014
Article CAS PubMed Google Scholar
Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S (2019) Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol 129:236–246. https://doi.org/10.1016/j.yjmcc.2019.03.006
Article CAS PubMed PubMed Central Google Scholar
Farrell E, Armstrong AE, Grimes AC, Naya FJ, de Lange WJ, Ralphe JC (2018) Transcriptome analysis of cardiac hypertrophic growth in MYBPC3-null mice suggests early responders in hypertrophic remodeling. Front Physiol. https://doi.org/10.3389/fphys.2018.01442
Article PubMed PubMed Central Google Scholar
Figtree GA, Broadfoot K, Casadei B, Califf R, Crea F, Drummond GR, Freedman JE, Guzik TJ, Harrison D, Hausenloy DJ, Hill JA, Januzzi JL, Kingwell BA, Lam CSP, MacRae CA, Misselwitz F, Miura T, Ritchie RH, Tomaszewski M, Wu JC, Xiao J, Zannad F (2021) A call to action for new global approaches to cardiovascular disease drug solutions. Eur Heart J 42:1464–1475. https://doi.org/10.1093/eurheartj/ehab068
Fougerousse F, Delezoide AL, Fiszman MY, Schwartz K, Beckmann JS, Carrier L (1998) Cardiac myosin binding protein C gene is specifically expressed in heart during murine and human development. Circ Res 82:130–133. https://doi.org/10.1161/01.res.82.1.130
Article CAS PubMed Google Scholar
Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD (2018) Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. J Clin Invest 128:2127–2143. https://doi.org/10.1172/jci98215
Article PubMed PubMed Central Google Scholar
Gautel M, Fürst DO, Cocco A, Schiaffino S (1998) Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle. Circ Res 82:124–129. https://doi.org/10.1161/01.res.82.1.124
Article CAS PubMed Google Scholar
Hamdani N, Kooij V, van Dijk S, Merkus D, Paulus WJ, Remedios C, Duncker DJ, Stienen GJM, van der Velden J (2007) Sarcomeric dysfunction in heart failure. Cardiovasc Res 77:649–658. https://doi.org/10.1093/cvr/cvm079
Article CAS PubMed Google Scholar
Hoshijima M, Chien KR (2002) Mixed signals in heart failure: cancer rules. J Clin Invest 109:849–855. https://doi.org/10.1172/JCI15380
Article CAS PubMed PubMed Central Google Scholar
Kampourakis T, Yan Z, Gautel M, Sun YB, Irving M (2014) Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells. Proc Natl Acad Sci U S A 111:18763–18768. https://doi.org/10.1073/pnas.1413922112
Article CAS PubMed PubMed Central Google Scholar
Kane LA, Neverova I, Van Eyk JE (2007) Subfractionation of heart tissue. In: Vivanco F (ed) Cardiovascular proteomics: methods and protocols. Humana Press, Totowa, NJ, p p 87-90
Kensler RW, Craig R, Moss RL (2017) Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments. Proc Natl Acad Sci U S A 114:E1355-e1364. https://doi.org/10.1073/pnas.1614020114
Article CAS PubMed PubMed Central Google Scholar
Korte FS, McDonald KS, Harris SP, Moss RL (2003) Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res 93:752–758. https://doi.org/10.1161/01.Res.0000096363.85588.9a
Article CAS PubMed Google Scholar
Li A, Nelson SR, Rahmanseresht S, Braet F, Cornachione AS, Previs SB, O’Leary TS, McNamara JW, Rassier DE, Sadayappan S, Previs MJ, Warshaw DM (2019) Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems. Proc Natl Acad Sci USA 116:21882–21892. https://doi.org/10.1073/pnas.1910549116
Article CAS PubMed PubMed Central Google Scholar
Li M, Parker BL, Pearson E, Hunter B, Cao J, Koay YC, Guneratne O, James DE, Yang J, Lal S, O’Sullivan JF (2020) Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nat Commun 11:2843. https://doi.org/10.1038/s41467-020-16584-z
Article CAS PubMed PubMed Central Google Scholar
Lin B, Govindan S, Lee K, Zhao P, Han R, Runte KE, Craig R, Palmer BM, Sadayappan S (2013) Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function. PLoS ONE 8:e69671. https://doi.org/10.1371/journal.pone.0069671
Article CAS PubMed PubMed Central Google Scholar
Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S (2018) Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca(2+)-dependent manner. Sci Rep 8:2604. https://doi.org/10.1038/s41598-018-21053-1
Article CAS PubMed PubMed Central Google Scholar
Lu P, Wu B, Feng X, Cheng W, Kitsis RN, Zhou B (2022) Cardiac myosin heavy chain reporter mice to study heart development and disease. Circ Res 131:364–366. https://doi.org/10.1161/CIRCRESAHA.122.321461
Article CAS PubMed PubMed Central Google Scholar
Lynch TLt, Kumar M, McNamara JW, Kuster DWD, Sivaguru M, Singh RR, Previs MJ, Lee KH, Kuffel G, Zilliox MJ, Lin BL, Ma W, Gibson AM, Blaxall BC, Nieman ML, Lorenz JN, Leichter DM, Leary OP, Janssen PML, de Tombe PP, Gilbert RJ, Craig R, Irving T, Warshaw DM, Sadayappan S (2021) Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility. J Mol Cell Cardiol 156:33–44. https://doi.org/10.1016/j.yjmcc.2021.03.009
Article CAS PubMed PubMed Central Google Scholar
Ma X, Gao L, Karamanlidis G, Gao P, Lee CF, Garcia-Menendez L, Tian R, Tan K (2015) Revealing pathway dynamics in heart diseases by analyzing multiple differential networks. PLoS Comput Biol 11:e1004332. https://doi.org/10.1371/journal.pcbi.1004332
Article CAS PubMed PubMed Central Google Scholar
Martini E, Kunderfranco P, Peano C, Carullo P, Cremonesi M, Schorn T, Carriero R, Termanini A, Colombo FS, Jachetti E, Panico C, Faggian G, Fumero A, Torracca L, Molgora M, Cibella J, Pagiatakis C, Brummelman J, Alvisi G, Mazza EMC, Colombo MP, Lugli E, Condorelli G, Kallikourdis M (2019) Single-cell sequencing of mouse heart immune infiltrate in pressure overload–driven heart failure reveals extent of immune activation. Circulation 140:2089–2107. https://doi.org/10.1161/CIRCULATIONAHA.119.041694
Article CAS PubMed Google Scholar
McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, Turnbull DH, Georgakopoulos D, Kass D, Bond M, Niimura H, Schoen FJ, Conner D, Fischman DA, Seidman CE, Seidman JG (1999) Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest 104:1235–1244. https://doi.org/10.1172/jci7377
Article CAS PubMed PubMed Central Google Scholar
McNamara JW, Sadayappan S (2018) Skeletal myosin binding protein-C: an increasingly important regulator of striated muscle physiology. Arch Biochem Biophys 660:121–128. https://doi.org/10.1016/j.abb.2018.10.007
Article CAS PubMed PubMed Central Google Scholar
McNamara JW, Singh RR, Sadayappan S (2019) Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. Proc Natl Acad Sci U S A 116:11731–11736. https://doi.org/10.1073/pnas.1821660116
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