Bøtker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schlüter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Nielsen TT (2010) Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375:727–734. https://doi.org/10.1016/S0140-6736(09)62001-8

Article  PubMed  Google Scholar 

Braunwald E (2012) The treatment of acute myocardial infarction: the past, the present, and the future. Eur Heart J Acute Cardiovasc Care 1:9–12. https://doi.org/10.1177/2048872612438026

Article  PubMed  PubMed Central  Google Scholar 

Braunwald E, Rutherford JD (2016) Limitation of infarct size and the open artery hypothesis: a conversation with Eugene Braunwald, MD. Circulation 134:839–846. https://doi.org/10.1161/CIRCULATIONAHA.116.024714

Article  PubMed  Google Scholar 

Brochier M, Raynaud R, Planiol T, Fauchier JP, Griguer P, Archambaud D, Pellois A, Clisson M (1975) Treatment by urokinase of myocardial infarction and threatened infarction. Randomised study of 120 cases. Arch Mal Coeur Vaiss 68:563–569

CAS  PubMed  Google Scholar 

Bulluck H, Sirker A, Loke YK, Garcia-Dorado D, Hausenloy DJ (2015) Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: an updated meta-analysis of randomized controlled trials. Int J Cardiol 202:228–237. https://doi.org/10.1016/j.ijcard.2015.09.005

Article  PubMed  PubMed Central  Google Scholar 

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Juni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B, Group ESCSD (2023) 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J 44:3720–3826. https://doi.org/10.1093/eurheartj/ehad191

Article  CAS  PubMed  Google Scholar 

Chazov EI, Matveeva LS, Mazaev AV, Sargin KE, Sadovskaia GV, Ruda MI (1976) Intracoronary administration of fibrinolysin in acute myocardial infarct. Ter Arkh 48:8–19

CAS  PubMed  Google Scholar 

Cung TT, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guerin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit JF, Jouve B, Motreff P, Tron C, Labeque JN, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice MC, Ider O, Dubois-Rande JL, Unterseeh T, Le Breton H, Beard T, Blanchard D, Grollier G, Malquarti M, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M (2015) Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373:1021–1023. https://doi.org/10.1056/NEJMoa1505489

Article  CAS  PubMed  Google Scholar 

Dalkara T, Ostergaard L, Heusch G, Attwell D (2024) Pericytes in the brain and heart: functional roles and response to ischemia and reperfusion. Cardiovasc Res 120:2336–2348. https://doi.org/10.1093/cvr/cvae147

Article  CAS  Google Scholar 

de Waha S, Patel MR, Granger CB, Ohman EM, Maehara A, Eitel I, Ben-Yehuda O, Jenkins P, Thiele H, Stone GW (2017) Relationship between microvascular obstruction and adverse events following primary primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J 38:3502–3510. https://doi.org/10.1093/eurheartj/ehx414

Article  CAS  PubMed  Google Scholar 

DeWood MA, Spores J, Notske R, Mouser LT, Burroughs R, Golden MS, Lang HT (1980) Prevalence of total coronary occlusion during the early hours of the transmural myocardial infarction. N Engl J Med 303:897–902. https://doi.org/10.1056/NEJM198010163031601

Article  CAS  PubMed  Google Scholar 

Eitel I, Stiermaier T, Rommel KP, Fuernau G, Sandri M, Mangner N, Linke A, Erbs S, Lurz P, Boudriot E, Mende M, Desch S, Schuler G, Thiele H (2015) Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J 36:3049–3057. https://doi.org/10.1093/eurheartj/ehv463

Article  PubMed  Google Scholar 

Falk E (1985) Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 71:699–708

Article  CAS  PubMed  Google Scholar 

Ferdinandy P, Andreadou I, Baxter GF, Bøtker HE, Davidson SM, Dobrev D, Gersh BJ, Heusch G, Lecour S, Ruiz-Meana M, Zuurbier CJ, Hausenloy DJ, Schulz R (2023) Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological treatments and ischemic conditioning. Pharmacol Rev 75:159–216. https://doi.org/10.1124/pharmrev.121.000348

Article  CAS  PubMed  Google Scholar 

Fletcher AP, Alkjaersig N, Smyrniotis FE, Sherry S (1958) The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy. Trans Assoc Am Physicians 71:287–296

CAS  PubMed  Google Scholar 

Fletcher AP, Sherry S, Alkjaersig N, Smyrniotis FE, Jick S (1959) The maintenance of a sustained thrombolytic state in man. II. Clinical observations on patients with myocardial infarction and other thromboembolic disorders. J Clin Invest 38:1111–1119. https://doi.org/10.1172/JCI103887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaspar A, Lourenço AP, Álvares Pereira M, Azevedo P, Roncon-Albuquerque R Jr, Marques J, Leite-Moreira AF (2018) Randomized controlled trial of remote ischemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol 113:14. https://doi.org/10.1007/s00395-018-0672-3

Article  PubMed  Google Scholar 

Gibbons RJ, Holmes DR, Reeder GS, Bailey KR, Hopfenspirger MR, Gersh BJ (1993) Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups. N Engl J Med 328:685–691. https://doi.org/10.1056/NEJM199303113281003

Article  CAS  PubMed  Google Scholar 

Ginks WR, Sybers HD, Maroko PR, Covell JW, Sobel BE, Ross J Jr (1972) Coronary artery reperfusion. II. Reduction of myocardial infarct size at 1 week after the coronary occlusion. J Clin Invest 51:2717–2723. https://doi.org/10.1172/JCI107091

Article  CAS  PubMed  PubMed Central  Google Scholar 

GISSI (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1:397–402

Google Scholar 

GUSTO (1993) The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med 329:1615–1622. https://doi.org/10.1056/NEJM199311253292204

Article  Google Scholar 

Hartzler GO, Rutherford BD, McConahay DR, Johnson WL Jr, McCallister BD, Gura GM Jr, Conn RC, Crockett JE (1983) Percutaneous transluminal coronary angioplasty with and without thrombolytic therapy for treatment of acute myocardial infarction. Am Heart J 106:965–973. https://doi.org/10.1016/0002-8703(83)90639-7

Article  CAS  PubMed  Google Scholar 

Hausenloy DJ, Kharbanda RK, Møller UK, Ramlall M, Aarøe J, Butler R, Bulluck H, Clayton T, Dana A, Dodd M, Engstrom T, Evans R, Flensted Lassen J, Frischknecht Christensen E, Garcia-Ruiz JM, Gorog DA, Hjort J, Houghton RF, Ibanez B, Knight R, Lippert FK, Lønborg JT, Maeng M, Milasinovic D, More R, Nicholas JM, Okkels Jensen L, Perkins A, Radovanovic N, Rakhit RD, Ravkilde J, Ryding AD, Schmidt MR, Skogstad Riddervold I, Toft Sørensen H, Stankovic G, Varma M, Webb I, Juhl Terkelsen C, Greenwood JP, Yellon DM, Bøtker HE (2019) Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet 394:1415–1424. https://doi.org/10.1016/S0140-6736(19)32039-2

Article  PubMed  PubMed Central  Google Scholar 

Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res 61:448–460. https://doi.org/10.1016/j.cardiores.2003.09.024

Article  CAS  PubMed  Google Scholar 

Herrick JB (1912) Clinical features of sudden obstruction of the coronary arteries. J Am Med Assoc 59:2015–2020

Article  Google Scholar 

Heusch G (2015) Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 116:674–699