WHO Classification of Tumours Editorial Board. Digestive system tumours (2019) Lyon (France): International Agency for Research on Cancer (WHO classification of tumours series, 5th ed.; vol. 1).
WHO Classification of Tumours Editorial Board. Digestive system tumours [Internet; beta version ahead of print] (2025) Lyon (France): International Agency for Research on Cancer; 2025 [accessed on 2026 February 17th ]. (WHO classification of tumours series, 6th ed.; vol. 1).
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM (2010) Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy. J Clin Gastroenterol 44:687–695. https://doi.org/10.1097/MCG.0b013e3181d7a6d4.
Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums (2005) World J Surg 29:92–101. https://doi.org/10.1007/s00268-004-7443-z.
Reid M, PehlivanogluB, Memis B, Roa JC, Muraki T, Koshiol J, Licitra G, Goodman M,Araya JC, Villaseca M, Losada H, Sarmiento JM, Dursun N, Basturk O, Adsay V (2026) Neuroendocrine carcinoma of the gallbladder: Clinicopathologic and Immunohistochemical Analysis of 31 Cases. Am J Surg Pathol. [accepted for publication]
Albores-Saavedra J, Batich K, Hossain S, Henson DE, Schwartz AM (2009) Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. Ann Diagn Pathol. 13:378–383. https://doi.org/10.1016/j.anndiagpath.2009.08.002.
Ayabe RI, Wach M, Ruff S, Martin S, Diggs L, Wiemken T, Hinyard L, Davis JL, Luu C, Hernandez JM (2019) Primary Gallbladder Neuroendocrine Tumors: Insights into a Rare Histology Using a Large National Database. Ann Surg Oncol 26:3577–3585. https://doi.org/10.1245/s10434-019-07440-6.
Article PubMed PubMed Central Google Scholar
WHO Classification of Tumours Editorial Board. Endocrine and Neuroendocrine Tumours (2025) Lyon (France): International Agency for Research on Cancer (WHO classification of tumours series, 5th ed.; vol. 10).
Vanoli A, Messina A, Gallotti A, Fugazzola P, Adsay V (2023). Well-Differentiated Neuroendocrine Tumor of the Gallbladder with Paraganglioma-Like Features: a Potential Mimicker of Gallbladder Paraganglioma. Endocr Pathol 34:358–360. https://doi.org/10.1007/s12022-023-09784-y.
Article CAS PubMed Google Scholar
Brierley JD, Gospodarowicz MK, Wittekind C, editors (2024) TNM classification of malignant tumours. 9th ed. Oxford: Wiley.
Eren OC, Bagci P, Balci S, Ohike N, Saka B, Sokmensuer C, Leblebici CB, Xue Y, Reid MD, Krasinskas AM, Kooby D, Maithel SK, Sarmiento J, Cheng JD, Taskin OC, Kapran Y, Tarcan ZC, Luchini C, Scarpa A, Basturk O, Adsay NV (2024) Subgrading of G2 Pancreatic Neuroendocrine Tumors as 2A (Ki67 3% to < 10%) Versus 2B (10% to ≤ 20%) Identifies Behaviorally Distinct Subsets in Keeping with the Evolving Management Protocols. Ann Surg Oncol 31:7001–7011. https://doi.org/10.1245/s10434-024-15632-y.
Article PubMed PubMed Central Google Scholar
Kiemen AL, Young ED, Blackford AL, Wu P, Burkhart RA, Burns WR, Cameron JL, Lafaro K, Shubert C, Gaillard Z, Ebong UA, Reucroft I, Shen Y, Dequiedt L, Matos V, Klöppel G, Kasajima A, He J, Hruban RH (2025) Prognostic Features in Surgically Resected Well-Differentiated Pancreatic Neuroendocrine Tumors: an Analysis of 904 Patients with 7882 Person-Years of Follow-Up. Endocr Pathol 36:24. https://doi.org/10.1007/s12022-025-09866-z.
Article CAS PubMed PubMed Central Google Scholar
Xue Y, Reid MD, Pehlivanoglu B, Obeng RC, Jiang H, Memis B, Lui SK, Sarmiento J, Kooby D, Maithel SK, El-Rayes B, Basturk O, Adsay V (2020) Morphologic Variants of Pancreatic Neuroendocrine Tumors: Clinicopathologic Analysis and Prognostic Stratification. Endocr Pathol 31:239–253. https://doi.org/10.1007/s12022-020-09628-z.
Article CAS PubMed Google Scholar
Konukiewitz B, von Hornstein M, Jesinghaus M, Steiger K, Weichert W, Detlefsen S, Kasajima A, Klöppel G (2020) Pancreatic neuroendocrine tumors with somatostatin expression and paraganglioma-like features. Hum Pathol 102:79–87. https://doi.org/10.1016/j.humpath.2020.07.004.
Article CAS PubMed Google Scholar
Taskin OC, Reid MD, Bagci P, Balci S, Armutlu A, Demirtas D, Pehlivanoglu B, Saka B, Memis B, Bozkurtlar E, Leblebici CB, Birceanu A, Xue Y, Erkan M, Kapran Y, Baygul A, Sokmensuer C, Scarpa A, Luchini C, Basturk O, Adsay V (2022) Infiltration pattern predicts metastasis and progression better than the T-stage and grade in pancreatic neuroendocrine tumors: a proposal for a novel infiltration-based morphologic grading. Mod Pathol 35:777–785. https://doi.org/10.1038/s41379-021-00995-4.
Article CAS PubMed Google Scholar
Koc S, Eren OC, Esmer R, Kasapoglu FU, Saka B, Taskin OC, Bagci P, Adsay NV, Gunduz-Demir C (2025) Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns. Endocr Pathol 36:2. https://doi.org/10.1007/s12022-025-09846-3.
Article PubMed PubMed Central Google Scholar
Liu Y, Esnakula AK, Jain S, Lin J, Panarelli N, Pyatibrat S, Karamchandani DM (2025) Spectra of well-differentiated neuroendocrine lesions in the extrahepatic biliary system: a case series. Histopathology 86:285–293. https://doi.org/10.1111/his.15316.
Volante M, Brizzi MP, Faggiano A, La Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C, De Rosa G, Dogliotti L, Colao A, Papotti M (2007) Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol 20:1172–1182. https://doi.org/10.1038/modpathol.3800954.
Article CAS PubMed Google Scholar
Taskin OC, Bellolio E, Dursun N, Seven IE, Roa JC, Araya JC, Villaseca M, Tapia O, Vance C, Saka B, Balci S, Bagci P, Losada H, Sarmiento J, Memis B, Pehlivanoğlu B, Basturk O, Reid MD, Koshiol J, Cheng JD, Kapran Y, Adsay V (2020) Non-neoplastic Polyps of the Gallbladder: A Clinicopathologic Analysis of 447 Cases. Am J Surg Pathol 44:467–476. https://doi.org/10.1097/PAS.0000000000001405.
Article PubMed PubMed Central Google Scholar
Lim HU, Chan CC, Knotts FB (2013) An incidental finding of carcinoid tumor of the cystic duct. J Surg Case Rep 2013:rjt021. https://doi.org/10.1093/jscr/rjt021.
Article PubMed PubMed Central Google Scholar
Frometa A, Chaudhary Y, Ansari O, Jagoo N, Kapadia I (2020) Neuroendocrine Tumor of the Gallbladder, a Rare Incidental Finding. HCA Healthc J Med 1:149–154. https://doi.org/10.36518/2689-0216.1009.
Article PubMed PubMed Central Google Scholar
Zhou S, Jiang S, Chen W, Yin H, Dong L, Zhao H, Han S, He X (2021) Biliary Neuroendocrine Neoplasms: Analysis of Prognostic Factors and Development and Validation of a Nomogram. Front Oncol 11:654439. https://doi.org/10.3389/fonc.2021.654439.
Article PubMed PubMed Central Google Scholar
Nesti C, Bräutigam K, Benavent M, Bernal L, Boharoon H, Botling J, Bouroumeau A, Brcic I, Brunner M, Cadiot G, Camara M, Christ E, Clerici T, Clift AK, Clouston H, Cobianchi L, Ćwikła JB, Daskalakis K, Frilling A, Garcia-Carbonero R, Grozinsky-Glasberg S, Hernando J, Hervieu V, Hofland J, Holmager P, Inzani F, Jann H, Jimenez-Fonseca P, Kaçmaz E, Kaemmerer D, Kaltsas G, Klimacek B, Knigge U, Kolasińska-Ćwikła A, Kolb W, Kos-Kudła B, Kunze CA, Landolfi S, La Rosa S, López CL, Lorenz K, Matter M, Mazal P, Mestre-Alagarda C, Del Burgo PM, van Dijkum EJMN, Oleinikov K, Orci LA, Panzuto F, Pavel M, Perrier M, Reims HM, Rindi G, Rinke A, Rinzivillo M, Sagaert X, Satiroglu I, Selberherr A, Siebenhüner AR, Tesselaar MET, Thalhammer MJ, Thiis-Evensen E, Toumpanakis C, Vandamme T, van den Berg JG, Vanoli A, van Velthuysen MF, Verslype C, Vorburger SA, Lugli A, Ramage J, Zwahlen M, Perren A, Kaderli RM (2023) Hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1–2 cm in size: a retrospective, Europe-wide, pooled cohort study. Lancet Oncol 24:187–194. https://doi.org/10.1016/S1470-2045(22)00750-1.
Sinkre PA, Murakata L, Rabin L, Hoang MP, Albores-Saavedra J (2001) Clear cell carcinoid tumor of the gallbladder: another distinctive manifestation of von Hippel-Lindau disease. Am J Surg Pathol 25:1334–1339. https://doi.org/10.1097/00000478-200110000-00017.
Article CAS PubMed Google Scholar
Gucer H, Szentgyorgyi E, Ezzat S, Asa SL, Mete O (2013) Inhibin-expressing clear cell neuroendocrine tumor of the ampulla: an unusual presentation of von Hippel-Lindau disease. Virchows Arch. 2013;463(4):593–597. https://doi.org/10.1007/s00428-013-1465-6.
Hackeng WM, Brosens LAA, Kim JY, O’Sullivan R, Sung YN, Liu TC, Cao D, Heayn M, Brosnan-Cashman J, An S, Morsink FHM, Heidsma CM, Valk GD, Vriens MR, Nieveen van Dijkum E, Offerhaus GJA, Dreijerink KMA, Zeh H, Zureikat AH, Hogg M, Lee K, Geller D, Marsh JW, Paniccia A, Ongchin M, Pingpank JF, Bahary N, Aijazi M, Brand R, Chennat J, Das R, Fasanella KE, Khalid A, McGrath K, Sarkaria S, Singh H, Slivka A, Nalesnik M, Han X, Nikiforova MN, Lawlor RT, Mafficini A, Rusev B, Corbo V, Luchini C, Bersani S, Pea A, Cingarlini S, Landoni L, Salvia R, Milione M, Milella M, Scarpa A, Hong SM, Heaphy CM, Singhi AD (2022) Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size. Gut 71:961–973. https://doi.org/10.1136/gutjnl-2020-322595.
Article CAS PubMed Google Scholar
Moser E, Ura A, Vogel L, Steiger K, Mogler C, Evert M, Märkl B, Scheidhauer K, Martignoni M, Friess H, von Werder A, Marinoni I, Perren A, Klöppel G, Kasajima A (2024) ARX, PDX1, ISL1, and CDX2 Expression Distinguishes 5 Subgroups of Pancreatic Neuroendocrine Tumors With Correlations to Histology, Hormone Expression, and Outcome. Mod Pathol 37:100595. https://doi.org/10.1016/j.modpat.2024.100595.
Article CAS PubMed Google Scholar
Vanoli A, Inzani F, Parente P, Albarello L, Fassan M, Grillo F, Messina A, Carlino A, Uccella S, Spaggiari P, La Rosa S, Rindi G (2025) S100 protein is commonly expressed in neuroendocrine tumours of major and minor ampulla. J Clin Pathol 78:503–504. https://doi.org/10.1136/jcp-2024-209658.
Article CAS PubMed Google Scholar
Pepper MA, Dulken BW, Wang Y, Zemek AJ, Martin BA, Charu V, Longacre TA (2024) S100 Protein Expression in Primary and Metastatic Neuroendocrine Neoplasms: A Specific Marker of Pancreatic Origin. Am J Surg Pathol 48:157–162. https://doi.org/10.1097/PAS.0000000000002154.
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