Davis A, Hoffman H (2019) Hearing loss: rising prevalence and impact. Bull World Health Organ 97:646-A. https://doi.org/10.2471/BLT.19.224683
Article PubMed PubMed Central Google Scholar
Bowl MR, Dawson SJ (2019) Age-related hearing loss. Cold Spring Harb Perspect Med. https://doi.org/10.1101/cshperspect.a033217
Article PubMed PubMed Central Google Scholar
Li FF, Wang JP, Zhang WJ, Zhou PT, Fan M, Cai Nea, Cai Y-F, Li M-X et al (2025) Trends and mechanisms of Alzheimer’s disease and hearing impairment: a 20-year perspective. Ageing Res Rev 110:102799, 102799. https://doi.org/10.1016/j.arr.2025.102799
Yeo BSY, Song H, Toh EMS, Ng LS, Ho CSH, Ho R et al (2023) Association of hearing aids and cochlear implants with cognitive decline and dementia: a systematic review and meta-analysis. JAMA Neurol 80(2):134–141. https://doi.org/10.1001/jamaneurol.2022.4427
Article PubMed PubMed Central Google Scholar
Lin FR, Pike JR, Albert MS, Arnold M, Burgard S, Chisolm Tea et al (2023) Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. Lancet 402(10404):786–797. https://doi.org/10.1016/s0140-6736(23)01406-x
Article PubMed PubMed Central Google Scholar
Schafer EC, Miller S, Manning J, Zhang Q, Lavi A, Bodish E et al (2021) Meta-analysis of speech recognition outcomes in younger and older adults with cochlear implants. Am J Audiol 30(3):481–496. https://doi.org/10.1044/2021_aja-20-00141
Schvartz-Leyzac KC, McClaskey CM, Dias JW, Pfingst BE, Harris KC (2025) Contributions of auditory nerve density and synchrony to speech understanding in older cochlear implant users. J Assoc Res Otolaryngol 26(3):317–329. https://doi.org/10.1007/s10162-025-00984-3
Article PubMed PubMed Central Google Scholar
Lazard DS, Doelling KB, Arnal LH (2023) Plasticity after hearing rehabilitation in the aging brain. Trends Hear 27:23312165231156412. https://doi.org/10.1177/23312165231156412
Article PubMed PubMed Central Google Scholar
Seyyedi M, Viana LM, Nadol JB Jr (2014) Within-subject comparison of word recognition and spiral ganglion cell count in bilateral cochlear implant recipients. Otol Neurotol 35(8):1446–1450. https://doi.org/10.1097/mao.0000000000000443
Article PubMed PubMed Central Google Scholar
Ramekers D, Versnel H, Strahl SB, Smeets EM, Klis SF, Grolman W (2014) Auditory-nerve responses to varied inter-phase gap and phase duration of the electric pulse stimulus as predictors for neuronal degeneration. J Assoc Res Otolaryngol 15(2):187–202. https://doi.org/10.1007/s10162-013-0440-x
Article PubMed PubMed Central Google Scholar
He S, Xu L, Skidmore J, Chao X, Jeng FC, Wang Rea, Wang H et al (2020) The effect of interphase gap on neural response of the electrically stimulated cochlear nerve in children with cochlear nerve deficiency and children with normal-sized cochlear nerves. Ear Hear 41(4):918–934. https://doi.org/10.1097/aud.0000000000000815
Schvartz-Leyzac KC, Colesa DJ, Buswinka CJ, Rabah AM, Swiderski DL, Raphael Yea et al (2020) How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance. J Acoust Soc Am 148(6):3900. https://doi.org/10.1121/10.0002882
Article CAS PubMed PubMed Central Google Scholar
Söderqvist S, Sinkkonen ST, Sivonen V (2022) The intraoperative relationship between intracochlear electrical field and excitability of the auditory nerve. Heliyon 8(12):e11970. https://doi.org/10.1016/j.heliyon.2022.e11970
Article PubMed PubMed Central Google Scholar
Ramekers D, Benav H, Klis SFL, Versnel H (2022) Changes in the electrically evoked compound action potential over time after implantation and subsequent deafening in Guinea Pigs. J Assoc Res Otolaryngol 23(6):721–738. https://doi.org/10.1007/s10162-022-00864-0
Article PubMed PubMed Central Google Scholar
van den Honert C, Mortimer JT (1979) The response of the myelinated nerve fiber to short duration biphasic stimulating currents. Ann Biomed Eng 7(2):117–125. https://doi.org/10.1007/bf02363130
Liberman MC (1978) Auditory-nerve response from cats raised in a low-noise chamber. J Acoust Soc Am 63(2):442–455. https://doi.org/10.1121/1.381736
Article CAS PubMed Google Scholar
Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su Sea, Su S-S et al (2018) Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. Cell 174(5):1247–63 e15. https://doi.org/10.1016/j.cell.2018.07.008
Article CAS PubMed PubMed Central Google Scholar
Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV (2018) Sensory neuron diversity in the inner ear is shaped by activity. Cell 174(5):1229–46. https://doi.org/10.1016/j.cell.2018.07.007
Article CAS PubMed PubMed Central Google Scholar
Petitpre C, Wu H, Sharma A, Tokarska A, Fontanet P, Wang Yea et al (2018) Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nat Commun 9(1):3691. https://doi.org/10.1038/s41467-018-06033-3
Article CAS PubMed PubMed Central Google Scholar
Siebald C, Vincent PFY, Bottom RT, Sun S, Reijntjes DOJ, Manca Mea et al (2023) Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties. Proc Natl Acad Sci U S A 120(31):e2217033120. https://doi.org/10.1073/pnas.2217033120
Article CAS PubMed PubMed Central Google Scholar
Sherrill HE, Jean P, Driver EC, Sanders TR, Fitzgerald TS, Moser Tea et al (2019) Pou4f1 defines a subgroup of type I spiral ganglion neurons and is necessary for normal inner hair cell presynaptic Ca(2+) signaling. J Neurosci 39(27):5284–5298. https://doi.org/10.1523/jneurosci.2728-18.2019
Article CAS PubMed PubMed Central Google Scholar
Liberman MC (1982) Single-neuron labeling in the cat auditory nerve. Science 216(4551):1239–1241. https://doi.org/10.1126/science.7079757
Article CAS PubMed Google Scholar
Gleich O, Wilson S (1993) The diameters of guinea pig auditory nerve fibres: distribution and correlation with spontaneous rate. Hear Res 5955(93):69–79. https://doi.org/10.1016/0378-5955(93)90022-s
Liberman LD, Wang H, Liberman MC (2011) Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses. J Neurosci 31(3):801–808. https://doi.org/10.1523/jneurosci.3389-10.2011
Article CAS PubMed PubMed Central Google Scholar
Sachs MB, Voigt HF, Young ED (1983) Auditory nerve representation of vowels in background noise. J Neurophysiol 50(1):27–45. https://doi.org/10.1152/jn.1983.50.1.27
Article CAS PubMed Google Scholar
Zeng FG, Turner CW, Relkin EM (1991) Recovery from prior stimulation. II: effects upon intensity discrimination. Hear Res 55(2):223–30. https://doi.org/10.1016/0378-5955(91)90107-k
Article CAS PubMed Google Scholar
Schmiedt RA, Mills JH, Boettcher FA (1996) Age-related loss of activity of auditory-nerve fibers. J Neurophysiol 76(4):2799–2803. https://doi.org/10.1152/jn.1996.76.4.2799
Article CAS PubMed Google Scholar
Wang M, Lin S, Xie R (2023) Apical-basal distribution of different subtypes of spiral ganglion neurons in the cochlea and the changes during aging. PLoS ONE 18(10):e0292676. https://doi.org/10.1371/journal.pone.0292676
Article CAS PubMed PubMed Central Google Scholar
Spongr VP, Flood DG, Frisina RD, Salvi RJ (1997) Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans. J Acoust Soc Am 101(6):3546–3553.
Comments (0)