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White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel
White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel
Tinnitus and hearing loss are the most prevalent service-related auditory disabilities among American veterans. Previous s...
Discovering Age- and Sex-Specific Genetic Risk Factors in Sensorineural Hearing Loss: Genome-Wide Evidence from Large-Scale Biobanks
Discovering Age- and Sex-Specific Genetic Risk Factors in Sensorineural Hearing Loss: Genome-Wide Evidence from Large-Scale Biobanks
Investigate the genetic components of sensorineural hearing loss (SNHL) by performing genome-wide meta-analyses using the ...
Development of the Surgical Implantation and Fixation of an Implanted Middle Ear Microphone, the “UmboMic,” in Cadaveric Sheep
Development of the Surgical Implantation and Fixation of an Implanted Middle Ear Microphone, the “UmboMic,” in Cadaveric Sheep
The UmboMic is a recently developed middle ear microphone that functions by detecting the sound-induced motion of the umbo...
Bayesian Uncertainty Quantification for A Fractional-Order Model of the Human Ear
Bayesian Uncertainty Quantification for A Fractional-Order Model of the Human Ear
We employ the Hamiltonian Monte Carlo (HMC) algorithm to estimate model parameters and quantify their uncertainties in a f...
Age-dependent Shifts in Spiral Ganglion Neuron Subtypes Are Associated with Interphase Gap-dependent Modulation of Electrically Evoked Compound Action Potentials in Mice
Age-dependent Shifts in Spiral Ganglion Neuron Subtypes Are Associated with Interphase Gap-dependent Modulation of Electrically Evoked Compound Action Potentials in Mice
Older adults with profound hearing loss can derive substantial benefit from cochlear implants (CIs), yet outcomes are more...
A Structural Equation Approach to Characterizing Growth and Nonlinearity Underlying Distortion Product Otoacoustic Emissions
A Structural Equation Approach to Characterizing Growth and Nonlinearity Underlying Distortion Product Otoacoustic Emissions
Distortion product otoacoustic emission (DPOAE) magnitudes measured in the ear canal in response to a range of primary sti...
Deaf Acoustics: Listening Through Hearing Aids with Thomas Edison
Deaf Acoustics: Listening Through Hearing Aids with Thomas Edison
The history of hearing aids is rife with examples of deaf invention, “sonic skills,” and other expert...
Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models
Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models
The auditory brainstem response (ABR) is a widely used objective electrophysiology measure for non-invasively assessing au...
A Time-Domain Model for the Generation of Spontaneous Otoacoustic Emissions in Resonant Cavities
A Time-Domain Model for the Generation of Spontaneous Otoacoustic Emissions in Resonant Cavities
A long-standing question in hearing science is whether spontaneous otoacoustic emissions (SOAEs) arise from a specific act...
Longitudinal Audiological and Vestibular Follow-up in Adult Cancer Patients Receiving Platinum-Based Chemotherapy
Longitudinal Audiological and Vestibular Follow-up in Adult Cancer Patients Receiving Platinum-Based Chemotherapy
Platinum-based chemotherapy is widely used in cancer care but carries a substantial risk of cochleotoxicity and vestibulot...
Single Intratympanic Injection of Proprietary Brain-Derived Neurotrophic Factor (OTO-413) in Subjects with Speech-in-Noise Hearing Impairment: a Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study
Single Intratympanic Injection of Proprietary Brain-Derived Neurotrophic Factor (OTO-413) in Subjects with Speech-in-Noise Hearing Impairment: a Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study
To evaluate the safety and tolerability and exploratory efficacy of OTO-413, an intratympanic-administered, sustained rele...
A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants
A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants
Simultaneous hearing and balance restoration through combined cochlear-vestibular implants (CVIs) offers a promis...
Development of Calcium Signaling in Postsynaptic Neurons of the Medial Nucleus of the Trapezoid Body in the Mouse
Development of Calcium Signaling in Postsynaptic Neurons of the Medial Nucleus of the Trapezoid Body in the Mouse
In the central nervous system, Ca2⁺ signaling plays a pivotal role in various cellular processes, including neuronal...
Impacts of Kv3.1 Channels on Action Potentials in Fusiform Neurons From the Dorsal Cochlear Nucleus of Mice Before and After Hearing Onset
Impacts of Kv3.1 Channels on Action Potentials in Fusiform Neurons From the Dorsal Cochlear Nucleus of Mice Before and After Hearing Onset
Kv3.1 channels are high-voltage-activated potassium channels that facilitate high-frequency firing in auditory brainstem n...
Comparing and Optimizing Tissue Clearing Protocols for Cochlear Immunostaining and 3D Reconstruction by Light-Sheet Microscopy
Comparing and Optimizing Tissue Clearing Protocols for Cochlear Immunostaining and 3D Reconstruction by Light-Sheet Microscopy
Current standard methods for immunohistochemical analysis of the inner ear rely on cryosectioning of the intact cochlea or...
Gain-Delay Decoupling in Human Stimulus Frequency Otoacoustic Emissions Reveals Constraints on Cochlear Nonlinear Amplification
Gain-Delay Decoupling in Human Stimulus Frequency Otoacoustic Emissions Reveals Constraints on Cochlear Nonlinear Amplification
The nonlinear cochlear amplifier, driven by outer hair cells, underlies the remarkable sensitivity and frequency selectivi...
Structural and Molecular Evidence for a Frequency-Dependent Electrochemical Gradient in the Human Cochlear Lateral Wall
Structural and Molecular Evidence for a Frequency-Dependent Electrochemical Gradient in the Human Cochlear Lateral Wall
The stria vascularis (SV) is a tripartite epithelium lining the lateral wall (LW) of the human cochlea, generating a posit...
Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human
Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human
Determine thresholds of vestibular compound action potentials (vCAPs) evoked by pulsed interaural bone-conducted vibration...
A Phenome-Wide Comorbidity Atlas of Age-Related Hearing Loss, Speech-in-Noise Deficits, and Tinnitus: Distinguishing Causal Signals from Correlation
A Phenome-Wide Comorbidity Atlas of Age-Related Hearing Loss, Speech-in-Noise Deficits, and Tinnitus: Distinguishing Causal Signals from Correlation
The present study employed a data-driven and hypothesis-free approach to identify comorbidities associated with age-relate...
Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea
Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea
The basilar membrane (BM) motion evoked by single or two-tone stimuli shows nonlinearity largely confined to the region of...
Longitudinal Vibrations in the Organ of Corti are Limited to Its Core
Longitudinal Vibrations in the Organ of Corti are Limited to Its Core
The goal of this research was to determine where in the organ of Corti (ooC) sound–induced, longitudinal vibrations ...
Clinical Norms for Evaluating Hearing Difficulty in Patients with “Normal” Hearing Thresholds
Clinical Norms for Evaluating Hearing Difficulty in Patients with “Normal” Hearing Thresholds
Ethics Approval and Consent to Participate All methods were approve...
The Effects of Broadband Elicitor Duration on Transient-Evoked Otoacoustic Emissions and a Psychoacoustic Measure of Gain Reduction
The Effects of Broadband Elicitor Duration on Transient-Evoked Otoacoustic Emissions and a Psychoacoustic Measure of Gain Reduction
Measures of the human medial olivocochlear reflex (MOCR) typically rely on long duration (> 100 ms) ...
On the Sharpness of Auditory Filters: Considering Subclinical Deficits Reveals Sharper Otoacoustic Emission Estimates of Frequency Selectivity in Humans
On the Sharpness of Auditory Filters: Considering Subclinical Deficits Reveals Sharper Otoacoustic Emission Estimates of Frequency Selectivity in Humans
Frequency selectivity plays a crucial role in auditory perception, yet its precise characterization in humans remains deba...
Latencies of Pulsed Distortion-Product Otoacoustic Emissions and Their Relation to Auditory Brainstem Responses
Latencies of Pulsed Distortion-Product Otoacoustic Emissions and Their Relation to Auditory Brainstem Responses
To assess system properties of the human auditory system, such as cochlear gain, frequency selectivity, and their dependen...
Enhanced 40 and 80 Hz Auditory Steady State Responses in Patients with Idiopathic Tinnitus
Enhanced 40 and 80 Hz Auditory Steady State Responses in Patients with Idiopathic Tinnitus
This study aimed to investigate changes in auditory processing using auditory steady state responses (ASSR) in patients wi...
Aging in the Primary Auditory Cortex
Aging in the Primary Auditory Cortex
Age-related auditory dysfunction affects half of all individuals 60 years and older, yet its causes are poorly un...
Predicting Cochlear Synaptopathy in Mice with Varying Degrees of Outer Hair Cell Dysfunction Using Auditory Evoked Potentials
Predicting Cochlear Synaptopathy in Mice with Varying Degrees of Outer Hair Cell Dysfunction Using Auditory Evoked Potentials
Although human temporal bones suggest that cochlear synapse numbers decline with age and noise exposure, no validated diag...
Translational Potential of the Avian Cortex
Translational Potential of the Avian Cortex
Birds have contributed to important hearing-science discoveries. Examples include cochlear development, hair cell regenera...
Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm
Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm
Inner ear research has experienced exponential growth for the last fifty years spurring the creation of novel scientific a...
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