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Neuropeptide Cyclo-Prolylglycine: Discovery, Pharmacological Effects, and Mechanism of Action
Neuropeptide Cyclo-Prolylglycine: Discovery, Pharmacological Effects, and Mechanism of Action
This article is a review of studies on the endogenous neuropeptide cyclo-prolylglycine (CPG), which was discovered in Russ...
The Brain Lactate Dehydrogenase of Little Ground Squirrels ( Pall) during Hibernation and Arousal
The Brain Lactate Dehydrogenase of Little Ground Squirrels ( Pall) during Hibernation and Arousal
Hibernation is a form of adaptation of some mammals, which is characterized by a significant decrease in the metabolic rat...
Sympathetic Regulation of Homeostatic Plasticity at the Cholinergic Neuromuscular Junction
Sympathetic Regulation of Homeostatic Plasticity at the Cholinergic Neuromuscular Junction
Reliable functioning of neuromuscular junctions in the respiratory and locomotor muscles is due to the ability of choliner...
Effect of Gestational Diabetes in Female Rats on Brain Astrocyte Functions in Their Offspring
Effect of Gestational Diabetes in Female Rats on Brain Astrocyte Functions in Their Offspring
Gestational diabetes mellitus (GDM) in the mother may impair fetal brain development through epigenetic mechanisms and met...
Effect of NMDA Receptor Blocker Hemantane in Combination with TRPV1 Agonist Capsaicin on Pain Response in Mice
Effect of NMDA Receptor Blocker Hemantane in Combination with TRPV1 Agonist Capsaicin on Pain Response in Mice
The TRPV1 ion channel and the NMDA receptor represent promising targets for the development of new analgesics. This study ...
Gasotransmitters (NO, HS, CO) as Contributors to the Nociceptive Process in the Trigeminovascular System
Gasotransmitters (NO, HS, CO) as Contributors to the Nociceptive Process in the Trigeminovascular System
Gasotransmitters (gas-mediators) such as nitric oxide (NO), hydrogen sulfide (H2S) and carbon monoxide (CO) are a promisin...
Induced Pluripotent Stem Cells: A Unique Model for Studying the Human Brain in Health and Disease
Induced Pluripotent Stem Cells: A Unique Model for Studying the Human Brain in Health and Disease
The discovery of human induced pluripotent stem cells (iPSCs) has opened the new opportunities for fundamental, translatio...
The Effect of Trehalose on Autophagy Gene Transcription and Ultrastructure in Neurons and Glia of 5-Month-Old db/db Mice, a Model of Type 2 Diabetes-Associated Neurodegeneration
The Effect of Trehalose on Autophagy Gene Transcription and Ultrastructure in Neurons and Glia of 5-Month-Old db/db Mice, a Model of Type 2 Diabetes-Associated Neurodegeneration
Type 2 diabetes is associated with the formation of features of Alzheimer’s disease (AD). A common mechanism appears...
Disruption of Blood Flow Autoregulation in the Middle Cerebral Artery Bed in Rats with Carotid Artery Stenosis
Disruption of Blood Flow Autoregulation in the Middle Cerebral Artery Bed in Rats with Carotid Artery Stenosis
Carotid artery stenosis results in chronic cerebral hypoperfusion and dysfunctions of cerebral vasculature. The aim of the...
Proteins as Candidates for the Neurodegeneration Biomarkers
Proteins as Candidates for the Neurodegeneration Biomarkers
To date, there are no blood protein markers which levels could reliably detect the early stages of neurodegeneration, and ...
The Evaluation of Serum Levels of Matrix Metalloproteinases in the Acute Period after Ischemic Stroke
The Evaluation of Serum Levels of Matrix Metalloproteinases in the Acute Period after Ischemic Stroke
The aim of the study was to evaluate the time course of changes of serum MMP-2 and MMP-9 levels in patients in the acute p...
Integrating the Multiscale Molecular Modelling Techniques in Identification of Rat-TTBK1 Inhibitors from Plant: Homology-Modelling, Docking, MD Simulation, PCA Analysis, Cluster Analysis and MMGB/SA Study
Integrating the Multiscale Molecular Modelling Techniques in Identification of Rat-TTBK1 Inhibitors from Plant: Homology-Modelling, Docking, MD Simulation, PCA Analysis, Cluster Analysis and MMGB/SA Study
Alzheimer’s disease (AD) is a disturbing mental condition that gradually deteriorates memory and learning capacities...
Neurochemical Analysis of the Effect of the Combination of Ladasten with Fabomotizole on the Dopaminergic System of the Mouse Brain in 6-Hydroxydophamine Model of Parkinsonian Syndrome
Neurochemical Analysis of the Effect of the Combination of Ladasten with Fabomotizole on the Dopaminergic System of the Mouse Brain in 6-Hydroxydophamine Model of Parkinsonian Syndrome
In this study, we performed a neurochemical analysis of the content of dopamine and its metabolites in the striatum of mic...
Combined Action of Benzodiazepine Tranquilizers and Peptide Anxiolytic Selank in BALB/с Mice
Combined Action of Benzodiazepine Tranquilizers and Peptide Anxiolytic Selank in BALB/с Mice
To date, benzodiazepine tranquilizers are the most widespread drugs, whose therapeutic effect is mediated by their binding...
Effect of the Microbiota Metabolite Butyric Acid on Behavior, Neuroinflammation, and Oxidative Stress Level in a Mouse Model of Dysbiosis
Effect of the Microbiota Metabolite Butyric Acid on Behavior, Neuroinflammation, and Oxidative Stress Level in a Mouse Model of Dysbiosis
According to modern concepts, the composition and diversity of the intestinal microbiota plays a significant role in maint...
PAPP-A-Mediated Proteolytic Cleavage of IGFBP-4 and Age-Related Changes in the Primary Culture of Rat Astrocytes
PAPP-A-Mediated Proteolytic Cleavage of IGFBP-4 and Age-Related Changes in the Primary Culture of Rat Astrocytes
The phenotype of “aging” nervous tissue, like other tissues, is associated with elevation of the quantity of s...
Colony Stimulating Factor 1 Receptor/c-Myc Axis Promotes Microglial M2 Polarization to Augment Proliferation of Glioma Cells
Colony Stimulating Factor 1 Receptor/c-Myc Axis Promotes Microglial M2 Polarization to Augment Proliferation of Glioma Cells
M2-polarized microglial phenotype has been demonstrated to exert a pro-tumor immune response. However, its underlying mech...
Ameliorative Effect of Curcumin on Long-Term Potentiation Impaired in Adult-Onset Hypothyroidism
Ameliorative Effect of Curcumin on Long-Term Potentiation Impaired in Adult-Onset Hypothyroidism
Thyroid hormone dysfunction may affect intracellular signaling cascades and have a role in regulating cognitive function, ...
Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature
Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature
Anxiety-phobic disorders are behavioral complications of chronic stress. Unfortunately, there is still no effective pharma...
Neuroprotective Effects of Curcumin in Acute Ischemic Stroke: Insights of Preclinical and Clinical Studies
Neuroprotective Effects of Curcumin in Acute Ischemic Stroke: Insights of Preclinical and Clinical Studies
Curcumin, The Golden Spice dates long back for the history of having medicinal effects in traditional practices like Ayurv...
Role of miR-30e-5p in the Occurrence and Development of Posterior Circulation Ischemic Stroke
Role of miR-30e-5p in the Occurrence and Development of Posterior Circulation Ischemic Stroke
Posterior circulation ischemic stroke (PCIS) is caused by occlusion of the vertebral basilar artery, with complex and dive...
Assessment of the Causality between Uric Acid and Epilepsy: Bidirectional Two-Sample Mendelian Randomization
Assessment of the Causality between Uric Acid and Epilepsy: Bidirectional Two-Sample Mendelian Randomization
Uric acid (UA) is essential in the physiological and pathophysiological processes of various diseases. The linkage between...
Investigating the Therapeutic Potential of Maharasnadi Kwath Constituents Against HTT Proteins in Huntington’s Disease: An In-Silico Pharmacological Approach
Investigating the Therapeutic Potential of Maharasnadi Kwath Constituents Against HTT Proteins in Huntington’s Disease: An In-Silico Pharmacological Approach
Huntington’s disease (HD) is a severe neurodegenerative disease marked by the progressive degradation of nerve cells...
Serotonin Receptors as a Potential Therapeutic Target in Epilepsy
Serotonin Receptors as a Potential Therapeutic Target in Epilepsy
The development of antiepileptic drugs has focused particularly on neurotransmitters involved in excitatory and inhibitory...
Effects of Ghrelin on Brain and Serum Inflammatory Parameters in PTZ-Kindling Model in Rats
Effects of Ghrelin on Brain and Serum Inflammatory Parameters in PTZ-Kindling Model in Rats
It is well known that inflammation has a significant function in the pathophysiology of epilepsy. This research study that...
Vitamin C Mitigates Neuronal Injury and Cognitive Impairment in Epileptic Rats Induced by Lithium Chloride–Pilocarpine Hydrochloride through Autophagy Regulation
Vitamin C Mitigates Neuronal Injury and Cognitive Impairment in Epileptic Rats Induced by Lithium Chloride–Pilocarpine Hydrochloride through Autophagy Regulation
Vitamin C, a crucial antioxidant, plays a significant role in various physiological processes like antioxidation, anti-inf...
Predictive Value of miR-574-5p in Acute Cerebral Infarction Combined with Obstructive Sleep Apnea Syndrome
Predictive Value of miR-574-5p in Acute Cerebral Infarction Combined with Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSAS) is a prevalent comorbidity in patients with acute cerebral infarction (ACI). This ...
Expression of Farnesylated EGFP in Primary Cultures of Neocortical Neurons Disrupts Dendritic Spine Development
Expression of Farnesylated EGFP in Primary Cultures of Neocortical Neurons Disrupts Dendritic Spine Development
Genetically encoded fluorescent proteins are widely used in biological research in general and in neurobiology in particul...
Possible Neuroprotective Effect of tDCS on Doxorubicin-Induced Neurotoxicity in Rats
Possible Neuroprotective Effect of tDCS on Doxorubicin-Induced Neurotoxicity in Rats
Doxorubicin (DOX), a chemotherapeutic medicine, are frequently utilized to treat various malignancies, even though it has ...
Olfactory Bulbectomy in Mice Induces an Increase in Hippocampal Pro-Nerve Growth Factor Protein Levels
Olfactory Bulbectomy in Mice Induces an Increase in Hippocampal Pro-Nerve Growth Factor Protein Levels
Olfactory bulbectomy in rodents is a wide-used model of cholinergic dysfunction, yet, the state of nerve growth factor sys...
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