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In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR
In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR
Abstract Serotonergic psychedelics are substances that induce alterations in mood, perception and thought, and have the ac...
SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome
SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome
Abstract Cannabinoid receptor 1 (CB1R), a G protein-coupled receptor, plays a fundamental role in synaptic plasticity. Abn...
Catching hold of COVID‐19‐related encephalitis by tracking ANGPTL4 signature in blood
Catching hold of COVID‐19‐related encephalitis by tracking ANGPTL4 signature in blood
Abstract Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in humans is characterized by a plethor...
Role of mass effect and trehalose on early erythrolysis after experimental intracerebral hemorrhage
Role of mass effect and trehalose on early erythrolysis after experimental intracerebral hemorrhage
Abstract The mechanisms of brain injury after intracerebral hemorrhage (ICH) involve mass effect-induced primary injury an...
Ferroptosis: An emerging therapeutic target in stroke
Ferroptosis: An emerging therapeutic target in stroke
Abstract Stroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological ...
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging
Abstract Understanding of Alzheimer's disease (AD) pathophysiology requires molecular assessment of how key pathological f...
Microcephaly gene Cenpj regulates axonal growth in cortical neurons through microtubule destabilization
Microcephaly gene Cenpj regulates axonal growth in cortical neurons through microtubule destabilization
Abstract Neocortex development comprises of a complex series of time- and space-specific processes to generate the typical...
Dopaminergic imaging in degenerative parkinsonisms, an established clinical diagnostic tool
Dopaminergic imaging in degenerative parkinsonisms, an established clinical diagnostic tool
ABSTRACT Parkinson’s disease (PD) and other neurodegenerative parkinsonisms are characterised by loss of striatal d...
E3 Ubiquitin Ligase Nedd4‐2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress
E3 Ubiquitin Ligase Nedd4‐2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress
ABSTRACT The neural precursor cell expressed developmentally downregulated protein 4-like (Nedd4-2) is an E3 ubiquitin lig...
Colony‐stimulating factor‐1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model
Colony‐stimulating factor‐1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model
ABSTRACT Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting...
Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model mice
Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model mice
Abstract It is imperative to develop novel therapeutic strategies for Alzheimer’s disease (AD) and related dementia...
Prolonged ethanol exposure modulates constitutive internalization and recycling of 5‐HT1A receptors
Prolonged ethanol exposure modulates constitutive internalization and recycling of 5‐HT1A receptors
Abstract Alcohol exposure alters the signaling of the serotoninergic system, which is involved in alcohol consumption, rew...
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease
Abstract Astrocytes are highly efficient homeostatic glial cells playing a crucial role in the optimal brain functioning a...
Inactivation of seeding activity of amyloid β‐protein aggregates in vitro
Inactivation of seeding activity of amyloid β‐protein aggregates in vitro
Abstract The deposition of amyloid beta-protein (Aβ) in the brain is a major pathological feature of Alzheimer's dis...
Disrupted circadian expression of beta‐arrestin 2 affects reward‐related µ‐opioid receptor function in alcohol dependence
Disrupted circadian expression of beta‐arrestin 2 affects reward‐related µ‐opioid receptor function in alcohol dependence
Abstract There is increasing evidence for a daily rhythm of μ-opioid receptor (MOR) efficacy and the development of ...
Inhibitors of ectonucleotidases have paradoxical effects on synaptic transmission in the mouse cortex
Inhibitors of ectonucleotidases have paradoxical effects on synaptic transmission in the mouse cortex
Abstract Extracellular adenosine plays prominent roles in the brain in both physiological and pathological conditions. Ade...
Disturbed cerebral circulation and metabolism matters
Disturbed cerebral circulation and metabolism matters
Abstract Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood vessels. Two main aims ...
Structural Amyloid Plaque Polymorphism is Associated with Distinct Lipid Accumulations Revealed by Trapped Ion Mobility Mass Spectrometry Imaging (TIMS MSI)
Structural Amyloid Plaque Polymorphism is Associated with Distinct Lipid Accumulations Revealed by Trapped Ion Mobility Mass Spectrometry Imaging (TIMS MSI)
ABSTRACT Understanding of Alzheimer’s disease (AD) pathophysiology, requires molecular assessment of how key pathol...
Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum
Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum
Abstract Cholinergic transmission underlies higher brain functions such as cognition and movement. To elucidate the proces...
Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning
Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning
Abstract The nucleus accumbens (NAc) plays critical roles in emotional behaviors, including aversive learning. Aversive st...
Sec3 exocyst component knockdown inhibits axonal formation and cortical neuronal migration during brain cortex development
Sec3 exocyst component knockdown inhibits axonal formation and cortical neuronal migration during brain cortex development
Abstract Neurons are the largest known cells, with complex and highly polarized morphologies and consist of a cell body (s...
A novel synaptopathy defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia
A novel synaptopathy defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia
Abstract Mutations in the ESCRT-III subunit CHMP2B cause frontotemporal dementia (FTD) and lead to impaired endolysosomal ...
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Abstract The prevention of tau protein aggregations is a therapeutic goal for the treatment of Alzheimer’s disease ...
Serum neurofilament light chain in adult and pediatric patients with myelin oligodendrocyte glycoprotein antibody‐associated disease: Correlation with relapses and seizures
Serum neurofilament light chain in adult and pediatric patients with myelin oligodendrocyte glycoprotein antibody‐associated disease: Correlation with relapses and seizures
ABSTRACT Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) causes major disability as a consequence ...
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation
ABSTRACT Neurodegeneration with brain iron accumulation (NBIA) is a clinically and genetically heterogeneous group of neur...
Antisense‐induced downregulation of major circadian genes modulates the expression of histone deacetylase‐2 (HDAC‐2) and CREB‐binding protein (CBP) in the medial shell region of nucleus accumbens of mice exposed to chronic excessive alcohol consumption
Antisense‐induced downregulation of major circadian genes modulates the expression of histone deacetylase‐2 (HDAC‐2) and CREB‐binding protein (CBP) in the medial shell region of nucleus accumbens of mice exposed to chronic excessive alcohol consumption
ABSTRACT Circadian genes in the medial accumbal shell (mNAcSh) region regulate binge alcohol consumption. Here, we investi...
TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia‐reperfusion injury via TAK1‐JNK/p38 pathway
TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia‐reperfusion injury via TAK1‐JNK/p38 pathway
Abstract TBC1Domain Family Member 25 (TBC1D25) is a protein that contains a TBC/RAB-GTPase activating protein (GAP) domain...
Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease
Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease
Abstract Understanding the molecular signaling mechanisms underlying cognition and neuronal plasticity would provide insig...
Endothelial cell biomarkers in critically ill COVID‐19‐patients with encephalitis
Endothelial cell biomarkers in critically ill COVID‐19‐patients with encephalitis
Abstract COVID-19 is associated with encephalitis in critically ill patients and endothelial dysfunction seems to contribu...
Neuronal membrane glycoprotein (nmgp‐1) gene deficiency affects chemosensation‐related behaviors, dauer exit and egg‐laying in Caenorhabditis elegans
Neuronal membrane glycoprotein (nmgp‐1) gene deficiency affects chemosensation‐related behaviors, dauer exit and egg‐laying in Caenorhabditis elegans
ABSTRACT The nervous system monitors the environment to maintain homeostasis, which can be affected by stressful condition...
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