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A Balanced Cannabinoids Mixture Protects Neural Stem/progenitor Cells from CoCl2 Induced Injury by Regulating Autophagy and Inflammation: An in Vitro Study
A Balanced Cannabinoids Mixture Protects Neural Stem/progenitor Cells from CoCl2 Induced Injury by Regulating Autophagy and Inflammation: An in Vitro Study
Although tetrahydrocannabinol (THC) and cannabidiol (CBD) have been individually studied for their neuroprotective roles, ...
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease
Tetracycline-derived compounds with anti-inflammatory properties have demonstrated neuroprotective potential in preclinica...
Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis
Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease causing motor neuron loss. 90–95% of ...
Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review
Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review
Oxaliplatin-induced peripheral neuropathy (OIPN) is a severe, dose-limiting complication that significantly reduces qualit...
Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation
Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation
Melamine, an industrial chemical linked to neurotoxicity, prompted this study investigating taurine’s neuroprotectiv...
Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis
Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis
We previously identified a set of genes with hypermethylated promoter regions that expressed reduced levels of mRNAs by ne...
The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity
The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity
The objective of the present review is to discuss the involvement of altered mitochondrial quality control in Mn-induced n...
Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors
Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, charac...
Protective Effect of Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model
Protective Effect of Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model
Background and Objectives: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neuro...
Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization
Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization
Background: Observational studies have shown that exposure to per- and polyfluoroalkyl substances can lead to neurotoxicit...
IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression
IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression
Cerebral ischemia-reperfusion (I/R) injury is the main cause of early complications and adverse outcomes after treatment s...
Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats
Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats
Atomoxetine (ATX) and methylphenidate (MPH) are routinely prescribed for the treatment of attention-deficit/hyperactivity ...
Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review
Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review
Arsenic is a prevalent and significant cause of poisoning worldwide, leading to both acute and chronic toxicity. The life-...
Niacin Protects iPSC-Derived Neurons from Chemotherapy-Induced Toxicity
Niacin Protects iPSC-Derived Neurons from Chemotherapy-Induced Toxicity
Neurotoxicity remains a major dose-limiting adverse effect of cancer therapy. Previous studies have indicated that niacin ...
Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review
Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, and repetitive and ag...
Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin
Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin
Excitotoxic signaling mediated by N-methyl-D-aspartate receptors (NMDARs) is inhibited by NMDAR/TRPM4 complex inhibitors s...
Tubuloside B Alleviates Aβ Induced PC12 Cell Injury by Attenuating Pyroptosis, Apoptosis and Excessive Autophagy
Tubuloside B Alleviates Aβ Induced PC12 Cell Injury by Attenuating Pyroptosis, Apoptosis and Excessive Autophagy
Cistanche, a traditional Chinese medicine with reported neuroprotective effects, contains multiple bioactive constituents ...
Role of LncRNA NEAT1 in Alzheimer’s Disease: Pathophysiological Insights and Therapeutic Approaches
Role of LncRNA NEAT1 in Alzheimer’s Disease: Pathophysiological Insights and Therapeutic Approaches
AD is a progressive neurodegenerative disease characterized by oxidative stress (OS), mitochondrial dysfunction, and synap...
Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP/PS1 Mice During Protracted Abstinence From Alcohol
Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP/PS1 Mice During Protracted Abstinence From Alcohol
Alzheimer’s disease (AD) is the leading cause of dementia and evidence suggests that alcohol, the most commonly used...
Camphor-Induced Seizures in Rats Increase the Potency of Gamma Oscillations During the Ictal Period, A Component that may Lead to Refractoriness in Seizure Control
Camphor-Induced Seizures in Rats Increase the Potency of Gamma Oscillations During the Ictal Period, A Component that may Lead to Refractoriness in Seizure Control
Particularly in the evaluation of substances that can cause neuronal hyperexcitability, triggering refractoriness to antie...
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Trimethyltin chloride (TMT) is a neurotoxicant that damages the central nervous system (CNS) and triggers neurodegeneratio...
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HA...
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Recent studies have identified the angiotensin-converting enzyme (ACE) gene as a potential candidate influencing Alzheimer...
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
Methamphetamine (METH) abuse and HIV infection are major public health concerns worldwide. While both METH and HIV- 1 Tat ...
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with HO
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with HO
This study investigates the potential protective role of annexin A1 (ANXA1) in cell models of H2O2-induced Alzheimer’...
Streptozotocin and L-Buthionine-Sulfoximine Decrease Neuron Membrane Lipid Packing and Alter Insulin Signaling
Streptozotocin and L-Buthionine-Sulfoximine Decrease Neuron Membrane Lipid Packing and Alter Insulin Signaling
Membrane composition, permeability and fluidity are essential for proper cellular function. According to the membrane agin...
Sabinene Inhibits Lipopolysaccharide-Induced Memory Decline by Enhancing Cholinergic Function, Decreasing Molybdenum Enzymes, and Suppressing Oxidative Stress and Neuroinflammation
Sabinene Inhibits Lipopolysaccharide-Induced Memory Decline by Enhancing Cholinergic Function, Decreasing Molybdenum Enzymes, and Suppressing Oxidative Stress and Neuroinflammation
Memory decline is a common hallmark signal of neurodegenerative diseases marked by elevated neuroinflammatory cyt...
Ketamine-Ethanol Combination Decreases Reduced Glutathione Levels and Activates both Intrinsic and Extrinsic Apoptotic Pathways Prior to Neuronal Death in SH-SY5Y Cells
Ketamine-Ethanol Combination Decreases Reduced Glutathione Levels and Activates both Intrinsic and Extrinsic Apoptotic Pathways Prior to Neuronal Death in SH-SY5Y Cells
Ketamine is an anesthetic drug that has been illegally used due to its hallucinogenic effects. Its use is often concomitan...
Correction to: Role of Synucleins in Alzheimer’s Disease
Correction to: Role of Synucleins in Alzheimer’s Disease
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 Internationa...
Dysregulation of Mitochondrial Iron Regulators as a Basis of Iron-Mediated Retinal Degeneration in Rats
Dysregulation of Mitochondrial Iron Regulators as a Basis of Iron-Mediated Retinal Degeneration in Rats
Iron accumulates with aging. This triggers various pathological changes and diseases. We studied the impact of iron admini...
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