Adamu A, Li S, Gao F, Xue G (2024) The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets. Front Aging Neurosci. https://doi.org/10.3389/fnagi.2024.1347987

Article  PubMed  PubMed Central  Google Scholar 

Afridi R, Tsuda M, Ryu H, Suk K (2022) The function of glial cells in the neuroinflammatory and neuroimmunological responses. Cells 11:659. https://doi.org/10.3390/cells11040659

Article  PubMed  PubMed Central  Google Scholar 

Agrawal A, Balcı H, Hanspers K et al (2024) WikiPathways 2024: next generation pathway database. Nucleic Acids Res 52:D679–D689. https://doi.org/10.1093/nar/gkad960

Article  PubMed  CAS  Google Scholar 

Agrawal I, Lim YS, Ng S-Y, Ling S-C (2022) Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine. Transl Neurodegener 11:48. https://doi.org/10.1186/s40035-022-00322-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Arai K, Lo EH (2017) Chap. 18 - Gliogenesis. In: Caplan LR, Biller J, Leary MC, (eds) Primer on Cerebrovascular Diseases (Second Edition). Academic Press, San Diego, pp 91–95

Asp M, Bergenstråhle J, Lundeberg J (2020) Spatially resolved transcriptomes—next generation tools for tissue exploration. Bioessays 42:1900221. https://doi.org/10.1002/bies.201900221

Article  Google Scholar 

Baldwin KR, Godena VK, Hewitt VL, Whitworth AJ (2016) Axonal transport defects are a common phenotype in drosophila models of ALS. Hum Mol Genet 25:2378–2392. https://doi.org/10.1093/hmg/ddw105

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bale AS, Jackson MD, Krantz QT et al (2007) Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo. Toxicol Sci 98:159–166. https://doi.org/10.1093/toxsci/kfm080

Article  PubMed  CAS  Google Scholar 

Bale AS, Tu Y, Carpenter-Hyland EP et al (2005) Alterations in glutamatergic and Gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience 130:197–206. https://doi.org/10.1016/j.neuroscience.2004.08.040

Article  PubMed  CAS  Google Scholar 

Barbeito AG, Martinez-Palma L, Vargas MR et al (2010) Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS. Neurobiol Dis 37:574–580. https://doi.org/10.1016/j.nbd.2009.11.007

Article  PubMed  CAS  Google Scholar 

Barberio J, Lally C, Kupelian V et al (2023) Estimated familial amyotrophic lateral sclerosis proportion: a literature review and meta-analysis. Neurol Genet 9:e200109. https://doi.org/10.1212/NXG.0000000000200109

Article  PubMed  PubMed Central  Google Scholar 

Barber SC, Mead RJ, Shaw PJ (2006) Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1762:1051–1067. https://doi.org/10.1016/j.bbadis.2006.03.008

Article  PubMed  CAS  Google Scholar 

Beckley JT, Woodward JJ (2011) The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex. Neuropsychopharmacology 36:1531–1542. https://doi.org/10.1038/npp.2011.38

Article  PubMed  PubMed Central  CAS  Google Scholar 

Benatar M, Robertson J, Andersen PM (2025) Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention. Lancet Neurol 24:77–86. https://doi.org/10.1016/S1474-4422(24)00479-4

Article  PubMed  CAS  Google Scholar 

Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Royal Stat Soc J Ser B: Methodological 57:289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x

Article  Google Scholar 

Berdyński M, Miszta P, Safranow K et al (2022) SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity. Sci Rep 12:103. https://doi.org/10.1038/s41598-021-03891-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boeynaems S, Bogaert E, Van Damme P, Van Den Bosch L (2016) Inside out: the role of nucleocytoplasmic transport in ALS and FTLD. Acta Neuropathol 132:159–173. https://doi.org/10.1007/s00401-016-1586-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brain KL, Trout SJ, Jackson VM et al (2001) Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores. Neuroscience 106:395–403. https://doi.org/10.1016/S0306-4522(01)00280-9

Article  PubMed  CAS  Google Scholar 

Braunscheidel K, Okas M, Woodward JJ (2024) Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons. Front Neurosci. https://doi.org/10.3389/fnins.2024.1366216

Article  PubMed  PubMed Central  Google Scholar 

Butti Z, Patten SA (2019) RNA dysregulation in amyotrophic lateral sclerosis. Front Genet 9:712. https://doi.org/10.3389/fgene.2018.00712

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cannon JR, Greenamyre JT (2011) The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci 124:225–250. https://doi.org/10.1093/toxsci/kfr239

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cavaliere F, Gülöksüz S (2022) Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm. Npj Mental Health Res 1:1–3. https://doi.org/10.1038/s44184-022-00018-3

Article  Google Scholar 

Chiò A, Calvo A, Traynor BJ (2021) Nature meets nurture in amyotrophic lateral sclerosis. Lancet Neurol 20:332–333. https://doi.org/10.1016/S1474-4422(21)00097-1

Article  PubMed  Google Scholar 

Chiò A, Mazzini L, D’Alfonso S et al (2018) The multistep hypothesis of ALS revisited: the role of genetic mutations. Neurology 91:e635–e642. https://doi.org/10.1212/WNL.0000000000005996

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chua JP, De Calbiac H, Kabashi E, Barmada SJ (2022) Autophagy and ALS: mechanistic insights and therapeutic implications. Autophagy 18:254–282. https://doi.org/10.1080/15548627.2021.1926656

Article  PubMed  CAS  Google Scholar 

Clarke BE, Patani R (2020) The microglial component of amyotrophic lateral sclerosis. Brain 143:3526–3539. https://doi.org/10.1093/brain/awaa309

Article  PubMed  PubMed Central  Google Scholar 

Collins M, Bowser R (2017) Chap. 4 - Molecular Mechanisms of Amyotrophic Lateral Sclerosis. In: Boulis N, O’Connor D, Donsante A (eds) Molecular and Cellular Therapies for Motor Neuron Diseases. Academic Press, pp 61–99

Crockford C, Newton J, Lonergan K et al (2018) ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS. Neurology 91:e1370–e1380. https://doi.org/10.1212/WNL.0000000000006317

Article  PubMed  PubMed Central  Google Scholar 

Cunha-Oliveira T, Montezinho L, Mendes C et al (2020) Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention. Oxid Med Cell Longev 2020:5021694. https://doi.org/10.1155/2020/5021694

Article  PubMed  PubMed Central  CAS  Google Scholar 

Davis AP, Wiegers TC, Sciaky D et al (2025) Comparative toxicogenomics database’s 20th anniversary: update 2025. Nucleic Acids Res 53:D1328–D1334. https://doi.org/10.1093/nar/gkae883

Article  PubMed