Airavaara M, Parkkinen I, Konovalova J, Albert K, Chmielarz P, Domanskyi A (2020) Back and to the future: from neurotoxin-induced to human Parkinson’s disease models. Current Protocols in Neuroscience 91(1):e88. https://doi.org/10.1002/cpns.88

Article  PubMed  Google Scholar 

Alves Fernandes TA, Tourville A, Ciss I, Ribeiro Silva R, de Andretto Mattos B, dos Santos Pereira M, Oblaza M, Brunel JM, Ferrié L, Raisman-Vozari R, Figadère B, Del-Bel E, Michel PP (2025) Oxytetracycline and its non-antibiotic derivative DOT protect midbrain dopamine neurons from iron-driven oxidative damage neurotoxicity. Research 43:16. https://doi.org/10.1007/s12640-025-00742-6

Article  CAS  Google Scholar 

Anthony WE, Wang B, Sukhum KV, D’Souza AW, Hink T, Cass C, Seiler S, Reske KA, Coon C, Dubberke ER, Burnham CD, Dantas G, Kwon JH (2022) Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults. Cell Rep 39(2):110649. https://doi.org/10.1016/j.celrep.2022.110649

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aponso PM, Faull RL, Connor B (2008) Increased progenitor cell proliferation and astrogenesis in the partial progressive 6-OHDA model of parkinson’s disease. Neuroscience 151:1142–1153. https://doi.org/10.1016/j.neuroscience.2007.11.036

Article  PubMed  CAS  Google Scholar 

Bahrami F, Morris DL, Pourgholami MH (2012) Tetracyclines: drugs with huge therapeutic potential. Mini Rev Med Chem 12(1):44–52. https://doi.org/10.2174/138955712798868977

Article  PubMed  CAS  Google Scholar 

Bains J, Cusulin J, Inoue W (2015) Stress-related synaptic plasticity in the hypothalamus. Nat Rev Neurosci 16:377–388. https://doi.org/10.1038/nrn3881

Article  PubMed  CAS  Google Scholar 

Balestrino R, Schapira AHV (2020) Parkinson’s disease. Eur J Neurol 27(1):27–42. https://doi.org/10.1111/ene.14108

Article  PubMed  CAS  Google Scholar 

Björklund A, Dunnett SB (2019) The amphetamine induced rotation test: a re-assessment of its use as a tool to monitor motor impairment and functional recovery in rodent models of parkinson’s disease. J Parkinson’s Disease 9(1):17–29. https://doi.org/10.3233/JPD-181525

Article  Google Scholar 

Bortolanza M, Cavalcanti-Kiwiatkoski R, Padovan-Neto FE, da-Silva CA, Mitkovski M, Raisman-Vozari R, Del-Bel E (2015) Glial activation is associated with L-DOPA-induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of PD. Neurobiol Dis 73:377–387. https://doi.org/10.1016/j.nbd.2014.10.017

Article  PubMed  CAS  Google Scholar 

Bortolanza M, do Nascimento GC, Raisman-Vozari R, Del-Bel E (2021) Doxycycline and its derivative, COL-3, decrease dyskinesia induced by l-DOPA in hemiparkinsonian rats. Br J Pharmacol 178(13):2595–2616. https://doi.org/10.1111/bph.15439

Article  PubMed  CAS  Google Scholar 

Bortolanza M, Nascimento GC, Socias SB, Ploper D, Chehín RN, Raisman-Vozari R, Del-Bel E (2018) Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease. J Neural Transm 125(10):1403–1415. https://doi.org/10.1007/s00702-018-1913-1

Article  PubMed  CAS  Google Scholar 

Brown TG, Thayer MN, VanTreeck JG, Zarate N, Hart DW, Heilbronner S, Gomez-Pastor R (2023) Striatal spatial heterogeneity, clustering, and white matter association of GFAP + astrocytes in a mouse model of Huntington’s disease. Front Cell Neurosci 17:1094503. https://doi.org/10.3389/fncel.2023.1094503

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carter RJ, Morton J, Dunnett SB (2001) Motor coordination and balance in rodents. Curr Protocols Neuros Sci. Chap. 8 https://doi.org/10.1002/0471142301.ns0812s15

Cenci MA, Lundblad M (2007) Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson’s disease in rats and mice. Curr Protocols Neurosci Chap 9. https://doi.org/10.1002/0471142301.ns0925s41

Clayton BL, Liddelow SA (2025) Heterogeneity of astrocyte reactivity. Annu Rev Neurosci 48(1):231–249. https://doi.org/10.1146/annurev-neuro-112723-031738

Article  PubMed  CAS  Google Scholar 

Clemens DL, Duryee MJ, Sarmiento C, Chiou A, McGowan JD, Hunter CD, Schlichte SL, Tian J, Klassen LW, O’Dell JR, Thiele GM, Mikuls TR, Zimmerman MC, Anderson DR (2018) Novel antioxidant properties of doxycycline. Int J Mol Sci 19(12):4078. https://doi.org/10.3390/ijms19124078

Article  PubMed  PubMed Central  Google Scholar 

Dias V, Junn E, Mouradian MM (2013) The role of oxidative stress in Parkinson’s disease. J Parkinson’s Disease 3(4):461–491. https://doi.org/10.3233/JPD-130230

Article  CAS  Google Scholar 

Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Outeiro TF (2021) Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo. Neurobiol Dis 151:105256. https://doi.org/10.1016/j.nbd.2021.105256

Article  PubMed  CAS  Google Scholar 

Dos Santos Pereira M, do Nascimento GC, Bortolanza M, Michel PP, Raisman-Vozari R, Del Bel E (2022) Doxycycline attenuates l-DOPA-induced dyskinesia through an anti-inflammatory effect in a hemiparkinsonian mouse model. Front Pharmacol 13:1045465. https://doi.org/10.3389/fphar.2022.1045465

Article  PubMed  PubMed Central  CAS  Google Scholar 

Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Verkhratsky A (2021) Reactive astrocyte nomenclature, definitions, and future. Nature/Neuroscience 24(3):312–325. https://doi.org/10.1038/s41593-020-00783-4

Article  PubMed  CAS  Google Scholar 

Estes ML, McAllister AK (2014) Alterations in immune cells and mediators in the brain: it’s not always neuroinflammation! Brain Pathol 24(6):623–630. https://doi.org/10.1111/bpa.12198

Article  PubMed  PubMed Central  CAS  Google Scholar 

Evans WR, Baskar SS, Vellore A, Costa ARCE, Jacob C, Ravoori S, Arigbe A, Huda R (2025) Chemogenetic control of striatal astrocytes improves parkinsonian motor deficits in mice. Glia 73(6):1188–1202. https://doi.org/10.1002/glia.24679

Article  PubMed  PubMed Central  Google Scholar 

Ferreira Junior NC, Dos Santos Pereira M, Francis N, Ramirez P, Martorell P, González-Lizarraga F, Figadère B, Chehin R, Del Bel E, Raisman-Vozari R, Michel PP (2021) The chemically modified tetracycline COL-3 and its parent compound doxycycline prevent microglial inflammatory responses by reducing glucose-mediated oxidative stress. Cells 10(8):2163. https://doi.org/10.3390/cells10082163

Article  PubMed  PubMed Central  CAS  Google Scholar 

Goetz CG (2011) The history of Parkinson’s disease: early clinical descriptions and neurological therapies. Cold Spring Harb Perspect Med 1(1):a008862. https://doi.org/10.1101/cshperspect.a008862

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gomes FV, Llorente R, Del Bel EA, Viveros MP, López-Gallardo M, Guimarães FS (2015) Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. Schizophr Res 164(1–3):155–163. https://doi.org/10.1016/j.schres.2015.01.015

Article  PubMed  Google Scholar 

Gomes MZ, Raisman-Vozari R, Del Bel EA (2008) A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain Res 1203:160–169. https://doi.org/10.1016/j.brainres.2008.01.088

Article  PubMed  CAS  Google Scholar 

Hirsch EC, Hunot S (2009) Neuroinflammation in PD: a target for neuroprotection? Lancet Neurol 8(4):382–397. https://doi.org/10.1016/S1474-4422(09)70062-6

Article  PubMed  CAS  Google Scholar 

Hudson JL, van Horne CG, Strömberg I, Brock S, Clayton J, Masserano J, Hoffer BJ, Gerhardt GA (1993) Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res 626(1–2):167–174. https://doi.org/10.1016/0006-8993(93)90576-9

Article  PubMed  CAS  Google Scholar 

Jacob G, Milan BA, Antonieto LR, Levi Y, Ribeiro MC, Nassar R, de Sousa-Neto MD, Mazzi-Chaves JF, Messora MR, Furlaneto FAC, Nascimento GC, Del-Bel E (2024) Experimental periodontitis worsens dopaminergic neuronal degeneration. J Clin Periodontol 52(1):159–170.