Adolfsson R, Gottfries CG, Oreland L, Wiberg A, Winblad B (1980) Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci 27(12):1029–1034. https://doi.org/10.1016/0024-3205(80)90025-9

Article  PubMed  CAS  Google Scholar 

Alzheimer's disease (2024) 2024 Alzheimer's disease facts and figures. Alzheimers Dement 20(5):3708–3821 https://doi.org/10.1002/alz.13809

Arango V, Underwood MD, Mann JJ (1994) Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics. Brain Res 650(1):1–8. https://doi.org/10.1016/0006-8993(94)90199-6

Article  PubMed  CAS  Google Scholar 

Barton EA, Baker C, Leasure JL (2017) Investigation of sex differences in the microglial response to binge ethanol and exercise. Brain Sci. https://doi.org/10.3390/brainsci7100139

Article  PubMed  PubMed Central  Google Scholar 

Beam CR, Kaneshiro C, Jang JY, Reynolds CA, Pedersen NL, Gatz M (2018) Differences between women and men in incidence rates of dementia and Alzheimer’s disease. J Alzheimers Dis 64(4):1077–1083. https://doi.org/10.3233/JAD-180141

Article  PubMed  PubMed Central  Google Scholar 

Branca C, Wisely EV, Hartman LK, Caccamo A, Oddo S (2014) Administration of a selective beta2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer’s disease. Neurobiol Aging 35(12):2726–2735. https://doi.org/10.1016/j.neurobiolaging.2014.06.011

Article  PubMed  PubMed Central  CAS  Google Scholar 

Burke WJ, Li SW, Schmitt CA, Xia P, Chung HD, Gillespie KN (1999) Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer’s disease: mechanism of neuron death. Brain Res 816(2):633–637. https://doi.org/10.1016/s0006-8993(98)01211-6

Article  PubMed  CAS  Google Scholar 

Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D (2018) Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice. J Neurosci 38(1):74–92. https://doi.org/10.1523/JNEUROSCI.1483-17.2017

Article  PubMed  CAS  Google Scholar 

Collaborators GBDNSD (2024) Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol 23(4):344–381. https://doi.org/10.1016/S1474-4422(24)00038-3

Article  Google Scholar 

Counts SE, Mufson EJ (2010) Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity. J Neurochem 113(3):649–660. https://doi.org/10.1111/j.1471-4159.2010.06622.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

DeBaker MC, Robinson JM, Moen JK, Wickman K, Lee AM (2019) Differential patterns of alcohol and nicotine intake: combined alcohol and nicotine binge consumption behaviors in mice. Alcohol. https://doi.org/10.1016/j.alcohol.2019.09.006

Article  PubMed  PubMed Central  Google Scholar 

DeBaker MC, Robinson JM, Moen JK, Wickman K, Lee AM (2020) Differential patterns of alcohol and nicotine intake: combined alcohol and nicotine binge consumption behaviors in mice. Alcohol 85:57–64. https://doi.org/10.1016/j.alcohol.2019.09.006

Article  PubMed  CAS  Google Scholar 

Deniz OG, Altun G, Kaplan AA, Yurt KK, von Bartheld CS, Kaplan S (2018) A concise review of optical, physical and isotropic fractionator techniques in neuroscience studies, including recent developments. J Neurosci Methods 310:45–53. https://doi.org/10.1016/j.jneumeth.2018.07.012

Article  PubMed  PubMed Central  Google Scholar 

DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener 14(1):32. https://doi.org/10.1186/s13024-019-0333-5

Article  PubMed  PubMed Central  Google Scholar 

Downs AM, Catavero CM, Kasten MR, McElligott ZA (2023) Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice. Alcohol 107:97–107. https://doi.org/10.1016/j.alcohol.2022.08.008

Article  PubMed  CAS  Google Scholar 

Du Y, Lee YB, Graves SM (2021) Chronic methamphetamine-induced neurodegeneration: differential vulnerability of ventral tegmental area and substantia nigra pars compacta dopamine neurons. Neuropharmacology 200:108817. https://doi.org/10.1016/j.neuropharm.2021.108817

Article  PubMed  PubMed Central  CAS  Google Scholar 

Du Y, Choi S, Pilski A, Graves SM (2022) Differential vulnerability of locus coeruleus and dorsal raphe neurons to chronic methamphetamine-induced degeneration. Front Cell Neurosci 16:949923. https://doi.org/10.3389/fncel.2022.949923

Article  PubMed  PubMed Central  CAS  Google Scholar 

Emilsson L, Saetre P, Balciuniene J, Castensson A, Cairns N, Jazin EE (2002) Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer’s disease patients. Neurosci Lett 326(1):56–60. https://doi.org/10.1016/s0304-3940(02)00307-5

Article  PubMed  CAS  Google Scholar 

Engel S, Dillerud M, Scalf M, Dobbelmann R, Du Y, Lee AM, Graves SM (2025) Alcohol consumption during early adulthood increases the vulnerability of locus coeruleus neurons and amyloid beta pathology in female APP/PS1 mice. Alcohol. https://doi.org/10.1016/j.alcohol.2025.05.004

Article  PubMed  PubMed Central  Google Scholar 

Evans AK, Ardestani PM, Yi B, Park HH, Lam RK, Shamloo M (2020) Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer’s disease. Neurobiol Dis 146:105089. https://doi.org/10.1016/j.nbd.2020.105089

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP (2006) Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 24(3):516–524. https://doi.org/10.1016/j.nbd.2006.08.017

Article  PubMed  CAS  Google Scholar 

Gong YS, Hou FL, Guo J, Lin L, Zhu FY (2021) Effects of alcohol intake on cognitive function and beta-amyloid protein in APP/PS1 transgenic mice. Food Chem Toxicol 151:112105. https://doi.org/10.1016/j.fct.2021.112105

Article  PubMed  CAS  Google Scholar 

Gong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, Xiao S, Lipton RB, Katz MJ, Wang C, Preux PM, Guerchet M, Gbessemehlan A, Ritchie K, Ancelin ML, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Kosmidis MH, Guaita A, Rolandi E, Davin A, Gureje O, Trompet S, Gussekloo J, Riedel-Heller S, Pabst A, Rohr S, Shahar S, Singh DKA, Rivan NFM, Boxtel MV, Kohler S, Ganguli M, Chang CC, Jacobsen E, Haan M, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Numbers K, Mather KA, Scazufca M, Lobo A, De-la-Camara C, Lobo E, Sachdev PS, Brodaty H, Hackett ML, Peters SAE, Woodward M, Cohort Studies of Memory in an International C (2023) Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium. Alzheimers Dement 19(8):3365–3378 https://doi.org/10.1002/alz.12962

Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020) Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci 23(1):15–20. https://doi.org/10.1038/s41593-019-0556-3

Article  PubMed  CAS  Google Scholar 

Graves SM, Schwarzschild SE, Tai RA, Chen Y, Surmeier DJ (2021) Mitochondrial oxidant stress mediates methamphetamine neurotoxicity in substantia nigra dopaminergic neurons. Neurobiol Dis 156:105409. https://doi.org/10.1016/j.nbd.2021.105409

Article  PubMed  PubMed Central  CAS  Google Scholar 

Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer’s disease. Neurobiol Aging 28(3):327–335. https://doi.org/10.1016/j.neurobiolaging.2006.02.007

Article  PubMed  CAS  Google Scholar 

Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O’Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA (2021) Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease. Commun Biol 4(1):711. https://doi.org/10.1038/s42003-021-02259-y

Article  PubMed  PubMed Central  Google Scholar 

Gustavsson A, Norton N, Fast T, Frolich L, Georges J, Holzapfel D, Kirabali T, Krolak-Salmon P, Rossini PM, Ferretti MT, Lanman L, Chadha AS, van der Flier WM (2023) Global estimates on the number of persons across the Alzheimer’s disease continuum. Alzheimers Dement 19(2):658–670. https://doi.org/10.1002/alz.12694