Funding

Supported by the Ministry of Health of the Czech Republic, Grant NU21-03-00539.

Conflict of interest

Alexandr Poprach has received research support from: Roche, Bristol Myers Squibb, Merck KGaA, MSD, and Novartis; consulting fees from Bristol Myers Squibb, Astellas, Janssen, and Sanofi/Aventis; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Ipsen, Bristol Myers Squibb, Roche, Novartis, Pfizer, MSD, and Pfizer. Igor Kiss has received research support from Roche, Bristol Myers Squibb, Merck KGaA, MSD, and Servier; consulting fees from Bristol Myers Squibb, Astellas, Janssen, and Sanofi/Aventis; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Ipsen, Bristol-Myers Squibb, Roche, Novartis, Pfizer, MSD, and Pfizer. Ondrej Fiala has received payment or honoraria for lectures, presentations, speakers’ bureaus, or educational events from Roche, Janssen, GSK, MSD, Pierre Fabre, BMS and Pfizer. Jindřich Kopecký has received consulting fees from Bristol Myers Squibb, Novartis, Pfizer, Merck, MSD, Ipsen; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Ipsen, Bristol Myers Squibb, MSD, Merck, Novartis and Pfizer. Igor Richter has received consulting fees from Bristol Myer Squibb, Pfizer, and Ipsen; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from Ipsen, Bristol-Myers Squibb, Janssen, Merck KGaA, and Bayer. Bohuslav Melichar has received consulting fees from Roche, Pfizer, BMS, Novartis, MSD, Merck Serono, Servier, AstraZeneca, Amgen, E. Lilly. Hana Studentova has received research support: Roche, and Novartis; consulting fees from Bristol Myer Squibb, Astellas, Janssen, and MSD; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from Ipsen, Bristol Myers Squibb, Janssen, and MSD. Radek Lakomy has received consulting fees from Bristol Myers Squibb, MSD, Novartis; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Bristol-Myers Squibb, MSD, Novartis, Sanofi/Aventis and Medison. Milos Holanek has received research support from Gilead, AstraZeneca, Novartis, Roche; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Roche, Novartis, Gilead, Pfizer, AstraZeneca, Amgen. Anezka Zemankova has received consulting fees from Bristol Myer Squibb, Ipsen, Merck; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from Bristol Myers Squibb, Ipsen, Merck, Pfizer and Servier. Tomas Buchler has received research support: AstraZeneca, Roche, Bristol Myers Squibb, Exelixis, Merck KGaA, MSD, and Novartis; consulting fees from Bristol Myers Squibb, Astellas, Janssen, and Sanofi/Aventis; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Ipsen, Bristol Myers Squibb, AstraZeneca, Roche, Servier, Accord, MSD, and Pfizer. All unrelated to the present paper. All of the above are unrelated to the present paper. Marek Svoboda, Michal Stanik, Tamara Barusova, Lenka Pospisilova, and Aneta Rozsypalova declare no conflicts of interest.

Ethics approval

The RENIS registry has been approved by the Ethical Committee of the Brno University Hospital.

Availability of data

The datasets generated during and analysed during the current study are not publicly available due to GDPR requirements but are available in fully anonymous version from the corresponding author on reasonable request.

Author contributions

Conceptualization: AP, TB, IK. Methodology: AP, TB, TB, LP. Data Acquisition: AP, IK, MS, OF, JK, IR, BM, HS, RL, MH, AR, AZ. Statistical analysis: TB, LP. Writing—Original Draft: AP, TB. Writing—Review and Editing: all authors. Supervision: IK, TB, MS.

Consent to participate

Informed consent was acquired from participants prior to their inclusion in the database in accordance with the Ethical Committee approval and national regulations.

Code availability

Not applicable.

Consent for publication

All authors agree with the publication.