Parkinson J. An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci. 2002;14(2):223–36 discussion 2.

Article  PubMed  Google Scholar 

Goetz CG. Charcot on Parkinson’s disease. Mov Disord. 1986;1(1):27–32.

Article  CAS  PubMed  Google Scholar 

Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2003;2(2):107–16.

Article  PubMed  Google Scholar 

Fasano A, Visanji NP, Liu LW, Lang AE, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2015;14(6):625–39.

Article  CAS  PubMed  Google Scholar 

Sakakibara R, Odaka T, Uchiyama T, Asahina M, Yamaguchi K, Yamaguchi T, et al. Colonic transit time and rectoanal videomanometry in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2003;74(2):268–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knudsen K, Fedorova TD, Bekker AC, Iversen P, Østergaard K, Krogh K, et al. Objective colonic dysfunction is far more prevalent than subjective constipation in Parkinson’s disease: a colon transit and volume study. J Parkinsons Dis. 2017;7(2):359–67.

Article  PubMed  Google Scholar 

Warnecke T, Schäfer KH, Claus I, Del Tredici K, Jost WH. Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management. NPJ Parkinsons Dis. 2022;8(1):31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barichella M, Severgnini M, Cilia R, Cassani E, Bolliri C, Caronni S, et al. Unraveling gut microbiota in Parkinson’s disease and atypical parkinsonism. Mov Disord. 2019;34(3):396–405.

Article  PubMed  Google Scholar 

Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22(11):657–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kola S, Prichard DO, Bharucha AE, Hassan A. A prospective pilot study of the effects of deep brain stimulation on olfaction and constipation in Parkinson’s disease. Clin Neurol Neurosurg. 2021;207:106774.

Article  PubMed  PubMed Central  Google Scholar 

Payne SC, Furness JB, Stebbing MJ. Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms. Nat Rev Gastroenterol Hepatol. 2019;16(2):89–105.

Article  PubMed  Google Scholar 

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88–100.

Article  PubMed  PubMed Central  Google Scholar 

Sakakibara R, Doi H, Fukudo S. Lewy body constipation. J Anus Rectum Colon. 2019;3(1):10–7.

Article  PubMed  PubMed Central  Google Scholar 

Camerucci E, Mullan AF, Bower JH, Bharucha AE, Turcano P, Stang CD, et al. Lifelong constipation in Parkinson’s disease and other clinically defined alpha-synucleinopathies: a population-based study in Southeast Minnesota. Parkinsonism Relat Disord. 2023;107:105244.

Article  CAS  PubMed  Google Scholar 

Mayeux R, Marder K, Cote LJ, Denaro J, Hemenegildo N, Mejia H, et al. The frequency of idiopathic Parkinson’s disease by age, ethnic group, and sex in northern Manhattan, 1988–1993. Am J Epidemiol. 1995;142(8):820–7.

Article  CAS  PubMed  Google Scholar 

Van Den Eeden SK, Tanner CM, Bernstein AL, Fross RD, Leimpeter A, Bloch DA, et al. Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity. Am J Epidemiol. 2003;157(11):1015–22.

Article  PubMed  Google Scholar 

Chen H, Shrestha S, Huang X, Jain S, Guo X, Tranah GJ, et al. Olfaction and incident Parkinson disease in US white and black older adults. Neurology. 2017;89(14):1441–7.

Article  PubMed  PubMed Central  Google Scholar 

GP2. The global Parkinson’s genetics program. Mov Disord. 2021;36(4):842–51.

Article  Google Scholar 

Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–70.

Article  PubMed  Google Scholar 

Step K, Eltaraifee E, Elsayed I, Rasaholiarison N, Okubadejo N, Walker R, et al. Advancing Parkinson’s disease research in Africa: a strategic training framework of the global Parkinson’s genetics program. Mov Disord. 2025;40(1):51–6.

Article  PubMed  Google Scholar 

Zhang M, Yang S, Li XC, Zhu HM, Peng D, Li BY, et al. Study on the characteristics of intestinal motility of constipation in patients with Parkinson’s disease. World J Gastroenterol. 2021;27(11):1055–63.

Article  PubMed  PubMed Central  Google Scholar 

Heetun ZS, Quigley EM. Gastroparesis and Parkinson’s disease: a systematic review. Parkinsonism Relat Disord. 2012;18(5):433–40.

Article  PubMed  Google Scholar 

Goetze O, Nikodem AB, Wiezcorek J, Banasch M, Przuntek H, Mueller T, et al. Predictors of gastric emptying in Parkinson’s disease. Neurogastroenterol Motil. 2006;18(5):369–75.

Article  CAS  PubMed  Google Scholar 

Marrinan S, Emmanuel AV, Burn DJ. Delayed gastric emptying in Parkinson’s disease. Mov Disord. 2014;29(1):23–32.

Article  CAS  PubMed  Google Scholar 

Edwards LL, Quigley EM, Harned RK, Hofman R, Pfeiffer RF. Characterization of swallowing and defecation in Parkinson’s disease. Am J Gastroenterol. 1994;89(1):15–25.

CAS  PubMed  Google Scholar 

Picillo M, Amboni M, Erro R, Longo K, Vitale C, Moccia M, et al. Gender differences in non-motor symptoms in early, drug naïve Parkinson’s disease. J Neurol. 2013;260(11):2849–55.

Article  PubMed  Google Scholar 

Srivanitchapoom P, Pandey S, Hallett M. Drooling in Parkinson’s disease: a review. Parkinsonism Relat Disord. 2014;20(11):1109–18.

Article  PubMed  PubMed Central  Google Scholar 

Johnston BT, Li Q, Castell JA, Castell DO. Swallowing and esophageal function in Parkinson’s disease. Am J Gastroenterol. 1995;90(10):1741–6.

CAS  PubMed  Google Scholar 

Fasano A, Bove F, Gabrielli M, Petracca M, Zocco MA, Ragazzoni E, et al. The role of small intestinal bacterial overgrowth in Parkinson’s disease. Mov Disord. 2013;28(9):1241–9.

Article  CAS  PubMed  Google Scholar 

Skjærbæk C, Knudsen K, Horsager J, Borghammer P. Gastrointestinal dysfunction in Parkinson’s disease. J Clin Med. 2021;10(3):625.

Article  Google Scholar 

Londos E, Hanxsson O, Alm Hirsch I, Janneskog A, Bülow M, Palmqvist S. Dysphagia in Lewy body dementia - a clinical observational study of swallowing function by videofluoroscopic examination. BMC Neurol. 2013;13:140.

Article  PubMed  PubMed Central  Google Scholar 

Furness JB. The enteric nervous system. Oxford, U.K.: Blackwell; 2006. p. 3–13.

Google Scholar 

Furness JB, Callaghan BP, Rivera LR, Cho HJ. The enteric nervous system and gastrointestinal innervation: integrated local and central control. Adv Exp Med Biol. 2014;817:39–71.

Article  PubMed  Google Scholar 

Sharkey KA, Mawe GM. The enteric nervous system. Physiol Rev. 2023;103(2):1487–564.