Fu H, Hardy J, Duff KE. Selective vulnerability in neurodegenerative diseases. Nat Neurosci. 2018;21(10):1350–8.
Article CAS PubMed PubMed Central Google Scholar
A novel gene. Containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. The Huntington’s Disease Collaborative Research Group. Cell. 1993;72(6):971–83.
Orr HT, Chung MY, Banfi S, Kwiatkowski TJ Jr, Servadio A, Beaudet AL, et al. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nat Genet. 1993;4(3):221–6.
Article CAS PubMed Google Scholar
Saunders A, Macosko EZ, Wysoker A, Goldman M, Krienen FM, de Rivera H, et al. Molecular diversity and specializations among the cells of the adult mouse brain. Cell. 2018;174(4):1015–e3016.
Article CAS PubMed PubMed Central Google Scholar
Zeisel A, Hochgerner H, Lönnerberg P, Johnsson A, Memic F, van der Zwan J, et al. Molecular architecture of the mouse nervous system. Cell. 2018;174(4):999–e101422.
Article CAS PubMed PubMed Central Google Scholar
Hodge RD, Bakken TE, Miller JA, Smith KA, Barkan ER, Graybuck LT, et al. Conserved cell types with divergent features in human versus mouse cortex. Nature. 2019;573(7772):61–8.
Article CAS PubMed PubMed Central Google Scholar
Siletti K, Hodge R, Mossi Albiach A, Lee KW, Ding SL, Hu L, et al. Transcriptomic diversity of cell types across the adult human brain. Science. 2023;382(6667):eadd7046.
Article CAS PubMed Google Scholar
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, et al. Single-cell transcriptomic analysis of Alzheimer’s disease. Nature. 2019;570(7761):332–7.
Article CAS PubMed PubMed Central Google Scholar
Mathys H, Boix CA, Akay LA, Xia Z, Davila-Velderrain J, Ng AP, et al. Single-cell multiregion dissection of Alzheimer’s disease. Nature. 2024;632(8026):858–68.
Article CAS PubMed PubMed Central Google Scholar
Pineda SS, Lee H, Ulloa-Navas MJ, Linville RM, Garcia FJ, Galani K, et al. Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD. Cell. 2024;187(8):1971–e8916.
Article CAS PubMed Google Scholar
Lee H, Fenster RJ, Pineda SS, Gibbs WS, Mohammadi S, Davila-Velderrain J, et al. Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation. Neuron. 2020;107(5):891–e9088.
Article CAS PubMed PubMed Central Google Scholar
Kamath T, Abdulraouf A, Burris SJ, Langlieb J, Gazestani V, Nadaf NM, et al. Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease. Nat Neurosci. 2022;25(5):588–95.
Article CAS PubMed PubMed Central Google Scholar
Ulland TK, Colonna M. TREM2 - a key player in microglial biology and Alzheimer disease. Nat Rev Neurol. 2018;14(11):667–75.
Article CAS PubMed Google Scholar
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, et al. A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk. Nature. 2022;603(7903):885–92.
Article CAS PubMed PubMed Central Google Scholar
Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature. 2018;554(7693):475–80.
Article CAS PubMed Google Scholar
Garcia FJ, Sun N, Lee H, Godlewski B, Mathys H, Galani K, et al. Single-cell dissection of the human brain vasculature. Nature. 2022;603(7903):893–9.
Article CAS PubMed PubMed Central Google Scholar
Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, et al. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022;185(20):3753–e6918.
Article CAS PubMed PubMed Central Google Scholar
Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022;375(6584):eabi7377.
Article CAS PubMed PubMed Central Google Scholar
Wälchli T, Ghobrial M, Schwab M, Takada S, Zhong H, Suntharalingham S, et al. Single-cell atlas of the human brain vasculature across development, adulthood and disease. Nature. 2024;632(8025):603–13.
Article PubMed PubMed Central Google Scholar
Xie Y, Yang F, He L, Huang H, Chao M, Cao H, et al. Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier. Neuron. 2024;112(18):3089–e1057.
Article CAS PubMed Google Scholar
Fish JE, Wythe JD. The molecular regulation of arteriovenous specification and maintenance. Dev Dyn. 2015;244(3):391–409.
Article CAS PubMed Google Scholar
Betsholtz C. Cell–cell signaling in blood vessel development and function. EMBO Mol Med. 2018;10(3):e8610.
Article PubMed PubMed Central Google Scholar
Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-brain barrier: from physiology to disease and back. Physiol Rev. 2019;99(1):21–78.
Article CAS PubMed Google Scholar
Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018;14(3):133–50.
Article CAS PubMed PubMed Central Google Scholar
Kaplan L, Chow BW, Gu C. Neuronal regulation of the blood-brain barrier and neurovascular coupling. Nat Rev Neurosci. 2020;21(8):416–32.
Article CAS PubMed PubMed Central Google Scholar
Chow BW, Gu C. The molecular constituents of the blood-brain barrier. Trends Neurosci. 2015;38(10):598–608.
Article CAS PubMed PubMed Central Google Scholar
Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018;21(10):1318–31.
Article CAS PubMed PubMed Central Google Scholar
Gross PM. Circumventricular organ capillaries. Prog Brain Res. 1992;91:219–33.
Article CAS PubMed Google Scholar
Mastorakos P, McGavern D. The anatomy and immunology of vasculature in the central nervous system. Sci Immunol. 2019;4(37):eaav0492.
Comments (0)