Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome

Payab M, Hasani-Ranjbar S, Shahbal N, Qorbani M, Aletaha A, Haghi-Aminjan H, et al. Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta-analysis of clinical trials. Phytother Res. 2020;34:526–45.

Article  CAS  PubMed  Google Scholar 

WHO. Obesity and overweight. 2021.

Li D, Yang Y, Wang S, He X, Liu M, Bai B, et al. Role of acetylation in doxorubicin-induced cardiotoxicity. Redox Biol. 2021;46:102089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obes (Silver Spring). 2020;28:1195–99.

Article  CAS  Google Scholar 

Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol. 2006;26:968–76.

Article  CAS  PubMed  Google Scholar 

Praso S, Jusupovic F, Ramic E, Gledo I, Ferkovic V, Novakovic B, et al. Obesity as a risk factor for artherial hypertension. Mater Sociomed. 2012;24:87–90.

Article  PubMed  PubMed Central  Google Scholar 

De Pergola G, Silvestris F. Obesity as a major risk factor for cancer. J Obes. 2013; 2013: 291546.

Seravalle G, Grassi G. Obesity and hypertension. Pharmacol Res. 2017;122:1–7.

Article  CAS  PubMed  Google Scholar 

Vural U, Aglar AA. What is the role of metabolic syndrome and obesity for postoperative atrial fibrillation after coronary bypass grafting? BMC Cardiovasc Disord. 2019;19:147.

Article  PubMed  PubMed Central  Google Scholar 

Kawada T. Food-derived regulatory factors against obesity and metabolic syndrome. Biosci Biotechnol Biochem. 2018;82:547–53.

Article  CAS  PubMed  Google Scholar 

Brown KA. Metabolic pathways in obesity-related breast cancer. Nat Rev Endocrinol. 2021;17:350–63.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Ma J, Yao K, Su W, Tan B, Wu X, et al. Circadian rhythms and obesity: timekeeping governs lipid metabolism. J Pineal Res. 2020;69:e12682.

Article  CAS  PubMed  Google Scholar 

SantaCruz-Calvo S, Bharath L, Pugh G, SantaCruz-Calvo L, Lenin RR, Lutshumba J, et al. Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities. Nat Rev Endocrinol. 2022;18:23–42.

Article  CAS  PubMed  Google Scholar 

Li X, Yang Y, Wang Z, Ju H, Fu X, Zou L, et al. Multistage-Responsive nanocomplexes attenuate ulcerative colitis by improving the accumulation and distribution of oral nucleic acid drugs in the Colon. ACS Appl Mater Interfaces. 2022;14:2058–70.

Article  CAS  PubMed  Google Scholar 

Fu X, He X, Yang Y, Jiang S, Wang S, Peng X, et al. Identification of transfer RNA-derived fragments and their potential roles in aortic dissection. Genomics. 2021;113:3039–49.

Article  CAS  PubMed  Google Scholar 

Yang P, Yang Y, He X, Sun P, Zhang Y, Song X, et al. miR-153-3p targets BetaII spectrin to regulate Formaldehyde-Induced cardiomyocyte apoptosis. Front Cardiovasc Med. 2021;8:764831.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zong T, Yang Y, Lin X, Jiang S, Zhao H, Liu M, et al. 5’-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection. Mol Ther Nucleic Acids. 2021;26:295–306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Yang Y, Wang Z, Jiang S, Meng Y, Song X, et al. Targeting non-coding RNAs in unstable atherosclerotic plaques: mechanism, regulation, possibilities, and limitations. Int J Biol Sci. 2021;17:3413–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suchanti S, Stephen BJ, Awasthi S, Awasthi SK, Singh G, Singh A, et al. Harnessing the role of epigenetic histone modification in targeting head and neck squamous cell carcinoma. Epigenomics. 2022;14:279–93.

Article  CAS  PubMed  Google Scholar 

Li X, Li X, Jinfeng Z, Yu T, Zhang B, Yang Y. Lysine acetylation and its role in the pathophysiology of acute pancreatitis. Inflamm Res. 2025;74:13.

Article  CAS  PubMed  Google Scholar 

Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, et al. Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteom. 2009;8:215–25.

Article  CAS  Google Scholar 

Morales-Tarre O, Alonso-Bastida R, Arcos-Encarnacion B, Perez-Martinez L, Encarnacion-Guevara S. Protein lysine acetylation and its role in different human pathologies: a proteomic approach. Expert Rev Proteom. 2021;18:949–75.

Article  CAS  Google Scholar 

Li P, Ge J, Li H. Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease. Nat Rev Cardiol. 2020;17:96–115.

Article  CAS  PubMed  Google Scholar 

Narita T, Weinert BT, Choudhary C. Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 2019;20:156–74.

Article  CAS  PubMed  Google Scholar 

Tapias A, Wang ZQ. Lysine acetylation and deacetylation in brain development and neuropathies. Genomics Proteom Bioinf. 2017;15:19–36.

Article  CAS  Google Scholar 

Yang X, Yang Y, Guo J, Meng Y, Li M, Yang P, et al. Targeting the epigenome in in-stent restenosis: from mechanisms to therapy. Mol Ther Nucleic Acids. 2021;23:1136–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian C, Yang Y, Bai B, Wang S, Liu M, Sun RC, et al. Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity. Int J Biol Sci. 2021;17:1328–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang P, Yang Y, Sun P, Tian Y, Gao F, Wang C, et al. βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases. Int J Biol Sci. 2021;17:32–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Yang Y, Wang Z, Zong T, Fu X, Aung LHH, et al. Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases. Angiogenesis. 2021;24:19–34.

Article  CAS  PubMed  Google Scholar 

Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, et al. NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis. 2020;11:776.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu T, Wang Z, Jie W, Fu X, Li B, Xu H, et al. The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases. Biochem Pharmacol. 2020;174:113797.

Article  CAS  PubMed  Google Scholar 

Norvell A, McMahon SB. Cell biology. Rise of the rival. Science. 2010;327:964–5.

Article  CAS  PubMed  Google Scholar 

Shakespear MR, Halili MA, Irvine KM, Fairlie DP, Sweet MJ. Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 2011;32:335–43.

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