Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice

Sun M, Kisseleva T. Reversibility of liver fibrosis. Clin Res Hepatol Gastroenterol. 2015;39(Suppl 1):S60-63

PubMed  PubMed Central  Google Scholar 

Benyon RC, Iredale JP. Is liver fibrosis reversible? Gut. 2000;46:443–446

CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol. 2011;6:425–456

CAS  PubMed  Google Scholar 

Consolo M, Amoroso A, Spandidos DA, Mazzarino MC. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review). Int J Mol Med. 2009;24:143–152

CAS  PubMed  Google Scholar 

Varol C, Mildner A, Jung S. Macrophages: development and tissue specialization. Annu Rev Immunol. 2015;33:643–675

CAS  PubMed  Google Scholar 

Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18:151–166

PubMed  Google Scholar 

Guillot A, Tacke F. Liver macrophages: old dogmas and new insights. Hepatol Commun. 2019;3:730–743

PubMed  PubMed Central  Google Scholar 

Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A. 2012;109:E3186-3195

CAS  PubMed  PubMed Central  Google Scholar 

Wang M, You Q, Lor K, Chen F, Gao B, Ju C. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol. 2014;96:657–665

PubMed  PubMed Central  Google Scholar 

Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O’Duibhir E, et al. The STAT3-IL-10-IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury. J Immunol. 2018;200:1169–1187

CAS  PubMed  Google Scholar 

Lodder J, Denaës T, Chobert MN, Wan J, El-Benna J, Pawlotsky JM, et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy. 2015;11:1280–1292

CAS  PubMed  PubMed Central  Google Scholar 

Campana L, Esser H, Huch M, Forbes S. Liver regeneration and inflammation: from fundamental science to clinical applications. Nat Rev Mol Cell Biol. 2021;22:608–624

CAS  PubMed  Google Scholar 

Jia W, Li H, He YW. The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood. 2005;106:3854–3859

CAS  PubMed  PubMed Central  Google Scholar 

Bian ZY, Wei X, Deng S, Tang QZ, Feng J, Zhang Y, et al. Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. J Mol Med (Berl). 2012;90:895–910

CAS  PubMed  Google Scholar 

Yang K, Li W, Bai T, Xiao Y, Yu W, Luo P, et al. Mindin deficiency alleviates renal fibrosis through inhibiting NF-κB and TGF-β/Smad pathways. J Cell Mol Med. 2020;24:5740–5750

CAS  PubMed  PubMed Central  Google Scholar 

Rana I, Kataria S, Tan TL, Hajam EY, Kashyap DK, Saha D, et al. Mindin (SPON2) is essential for cutaneous fibrogenesis in a mouse model of systemic sclerosis. J Invest Dermatol. 2023;143:699-710.e610

CAS  PubMed  Google Scholar 

Sun P, Zhang P, Wang PX, Zhu LH, Du Y, Tian S, et al. Mindin deficiency protects the liver against ischemia/reperfusion injury. J Hepatol. 2015;63:1198–1211

CAS  PubMed  Google Scholar 

Cheng XS, Huo YN, Fan YY, Xiao CX, Ouyang XM, Liang LY, et al. Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice. J Cell Mol Med. 2020;24:8391–8404

CAS  PubMed  PubMed Central  Google Scholar 

Hammerich L, Tacke F. Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol. 2023;20:633–646

CAS  PubMed  Google Scholar 

Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58:1461–1473

CAS  PubMed  Google Scholar 

Tacke F. Targeting hepatic macrophages to treat liver diseases. J Hepatol. 2017;66:1300–1312

CAS  PubMed  Google Scholar 

He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004;5:88–97

CAS  PubMed  Google Scholar 

Liu YS, Wang LF, Cheng XS, Huo YN, Ouyang XM, Liang LY, et al. The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation. J Cell Mol Med. 2019;23:3402–3416

CAS  PubMed  PubMed Central  Google Scholar 

Lamers C, Plüss CJ, Ricklin D. The promiscuous profile of complement receptor 3 in ligand binding, immune modulation, and pathophysiology. Front Immunol. 2021;12: 662164

CAS  PubMed  PubMed Central  Google Scholar 

Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M. Visualization of integrin Mac-1 in vivo. J Immunol Methods. 2015;426:120–127

CAS  PubMed  PubMed Central  Google Scholar 

Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol. 2016;13:316–327

CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif