Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–263
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7: 6
Toh MR, Wong EYT, Wong SH, Ng AWT, Loo LH, Chow PK, et al. Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology. 2023;164:766–782
Singal AG, Kanwal F, Llovet JM. Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy. Nat Rev Clin Oncol. 2023;20:864–884
Sinha RA. Targeting nuclear receptors for NASH/MASH: from bench to bedside. Liver Res. 2024;8:34–45
Article CAS PubMed PubMed Central Google Scholar
Carr BI, Guerra V, Ince V, Isik B, Yilmaz S. Discordance among aggressiveness characteristics of hepatocellular carcinoma: portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein level. Liver Res. 2023;7:256–262
Article CAS PubMed PubMed Central Google Scholar
Marasco LE, Kornblihtt AR. The physiology of alternative splicing. Nat Rev Mol Cell Biol. 2023;24:242–254
Article CAS PubMed Google Scholar
Burge CB, Padgett RA, Sharp PA. Evolutionary fates and origins of U12-type introns. Mol Cell. 1998;2:773–785
Article CAS PubMed Google Scholar
Fast NM. Intron splicing: U12 spliceosomal introns not so “minor” after all. Curr Biol. 2021;31:R912–R914
Article CAS PubMed Google Scholar
Bradley RK, Anczukow O. RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer. 2023;23:135–155
Article CAS PubMed PubMed Central Google Scholar
Kiianitsa K, Lukes ME, Hayes BJ, Brutman JN, Valdmanis PN, Bird TD, et al. TREM2 variants that cause early dementia and increase Alzheimer’s disease risk affect gene splicing. Brain. 2024;147:2368–2383
Article PubMed PubMed Central Google Scholar
Ibrahim EC, Hims MM, Shomron N, Burge CB, Slaugenhaupt SA, Reed R. Weak definition of IKBKAP exon 20 leads to aberrant splicing in familial dysautonomia. Hum Mutat. 2007;28:41–53
Article CAS PubMed Google Scholar
Wang F, Pan J, Liu Y, Meng Q, Lv P, Qu F, et al. Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proc Natl Acad Sci U S A. 2015;112:4743–4748
Article CAS PubMed PubMed Central Google Scholar
Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, et al. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 2021;33(2004–2020): e2009
Guo L, Ke H, Zhang H, Zou L, Yang Q, Lu X, et al. TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms. Cell Death Dis. 2022;13:428
Article CAS PubMed PubMed Central Google Scholar
Chen X, Yang HT, Zhang B, Phillips JW, Cheng D, Rigo F, et al. The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells. Proc Natl Acad Sci U S A. 2023;120: e2220190120
Article CAS PubMed PubMed Central Google Scholar
Wang H, Gao MX, Li L, Wang B, Hori N, Sato K. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Genomics. 2007;89:59–69
Article CAS PubMed Google Scholar
Li B, Liu S, Zheng W, Liu A, Yu P, Wu D, et al. RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nat Biotechnol. 2024;42:119–131
Article CAS PubMed Google Scholar
Tan YW, Hong W, Liu DX. Binding of the 5’-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcription. Nucleic Acids Res. 2012;40:5065–5077
Article CAS PubMed PubMed Central Google Scholar
Cotroneo CE, Mangano N, Dragani TA, Colombo F. Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants. Eur J Hum Genet. 2021;29:1019–1026
Article CAS PubMed PubMed Central Google Scholar
Song J, Zheng J, Liu X, Dong W, Yang C, Wang D, et al. A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5. J Exp Clin Cancer Res. 2022;41:171
Article CAS PubMed PubMed Central Google Scholar
Guo B, Zhang H, Wang J, Wu R, Zhang J, Zhang Q, et al. Identification of the signature associated with m(6)A RNA methylation regulators and m(6)A-related genes and construction of the risk score for prognostication in Early-Stage Lung Adenocarcinoma. Front Genet. 2021;12: 656114
Article CAS PubMed PubMed Central Google Scholar
Chen C, Huang F, Li X, Liu L, Zhang J, Zhao J, et al. Identification of splicing factors signature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC. Biochimica et Biophysica Acta (BBA). 2024;1870: 167115
Shen S, Park JW, Lu ZX, Lin L, Henry MD, Wu YN, et al. rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. Proc Natl Acad Sci U S A. 2014;111:E5593–5601
Article CAS PubMed PubMed Central Google Scholar
Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342–348
Article CAS PubMed Google Scholar
Sungalee S, Liu Y, Lambuta RA, Katanayeva N, Donaldson Collier M, Tavernari D, et al. Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci. Nat Genet. 2021;53:650–662
Article CAS PubMed Google Scholar
Wang M, Chen Z, Zhang Y. CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos. EMBO J. 2022;41: e112012
Article CAS PubMed PubMed Central Google Scholar
Wong JJ, Ritchie W, Ebner OA, Selbach M, Wong JW, Huang Y, et al. Orchestrated intron retention regulates normal granulocyte differentiation. Cell. 2013;154:583–595
Article CAS PubMed Google Scholar
Liu J, Kruswick A, Dang H, Tran AD, Kwon SM, Wang XW, et al. Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth. Nat Commun. 2017;8:137
Article PubMed PubMed Central Google Scholar
Jadhav V, Vaishnaw A, Fitzgerald K, Maier MA. RNA interference in the era of nucleic acid therapeutics. Nat Biotechnol. 2024;42:394–405
Article CAS PubMed Google Scholar
Biamonti G, Catillo M, Pignataro D, Montecucco A, Ghigna C. The alternative splicing side of cancer. Semin Cell Dev Biol. 2014;32:30–36
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