Dhaliwal A, Armstrong MJ. Sarcopenia in cirrhosis: a practical overview. Clin Med. 2020;20(5):489–492

Article  Google Scholar 

Kim HY, Jang JW. Sarcopenia in the prognosis of cirrhosis: going beyond the MELD score. World J Gastroenterol. 2015;21(25):7637–7647

Article  PubMed  PubMed Central  Google Scholar 

Shin MJ, Jeon YK, Kim IJ. Testosterone and sarcopenia. World J Mens Health. 2018;36(3):192–198

Article  PubMed  PubMed Central  Google Scholar 

Sinclair M, Gow PJ, Grossmann M, Shannon A, Hoermann R, Angus PW. Low serum testosterone is associated with adverse outcome in men with cirrhosis independent of the model for end-stage liver disease score. Liver Transpl. 2016;22(11):1482–1490

Article  PubMed  Google Scholar 

Singh Tejavath A, Mathur A, Nathiya D, Singh P, Raj P, Suman S, et al. Impact of branched chain amino acid on muscle mass, muscle strength, physical performance, combined survival, and maintenance of liver function changes in laboratory and prognostic markers on sarcopenic patients with liver cirrhosis (BCAAS study): a randomized clinical trial. Front Nutr. 2021;22(8): 715795

Article  Google Scholar 

Aamann L, Dam G, Borre M, Drljevic-Nielsen A, Overgaard K, Andersen H, et al. Resistance training increases muscle strength and muscle size in patients with liver cirrhosis. Clin Gastroenterol Hepatol. 2020;18(5):1179-1187.e6

Article  PubMed  Google Scholar 

Tandon P, Montano-Loza AJ, Lai JC, Dasarathy S, Merli M. Sarcopenia and frailty in decompensated cirrhosis. J Hepatol. 2021;75(Suppl 1(Suppl 1)):S147–S162

Article  PubMed  PubMed Central  Google Scholar 

de Felice I, Ridola L, Riggio O, et al. Transjugular intrahepatic portosystemic shunt placement: effects on nutritional status in cirrhosis patients. J Clin Med. 2023;12(22):7029

Article  PubMed  PubMed Central  Google Scholar 

Tandon P, Tangri N, Thomas L, Zenith L, Shaikh T, Carbonneau M, et al. A rapid bedside screen to predict unplanned hospitalization and death in outpatients with cirrhosis: a prospective evaluation of the clinical frailty scale. Am J Gastroenterol. 2016;111:1759–1767

Article  PubMed  Google Scholar 

Lai JC, Dodge JL, Kappus MR, Dunn MA, Volk ML, Duarte-Rojo A, et al. Changes in frailty are associated with waitlist mortality in patients with cirrhosis. J Hepatol. 2020;73(3):575–581

Article  PubMed  PubMed Central  Google Scholar 

Sinclair M, Grossmann M, Hoermann R, Angus PW, Gow PJ. Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: a randomised controlled trial. J Hepatol. 2016;65(5):906–913

Article  CAS  PubMed  Google Scholar 

Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300–307

Article  PubMed  Google Scholar 

Tripathi H, Benjamin J, Maiwall R, Puri P, Kapoor PB, Sarin SK, et al. Identifying critically ill patients with cirrhosis who benefit from nutrition therapy: the mNUTRIC score study. J Clin Transl Res. 2022;8(5):425–433

CAS  PubMed  PubMed Central  Google Scholar 

Freites-Martinez A, Santana N, Arias-Santiago S, Viera A. Using the common terminology criteria for adverse events (CTCAE—Version 5.0) to evaluate the severity of adverse events of anticancer therapies. Actas Dermo-Sifiliográficas (English Edition). 2021;112(1):90–92

Article  CAS  Google Scholar 

European Association for the Study of the Liver. EASL clinical practice guidelines on nutrition in chronic liver disease. J Hepatol. 2019;70(1):172–193

Article  Google Scholar 

Park SS, Lim S, Kim H, Kim KM. Comparison of two DXA systems, Hologic Horizon W and GE Lunar Prodigy, for assessing body composition in healthy Korean adults. Endocrinol Metab Seoul. 2021;36(6):1219–1231

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eriksen CS, Møller S. Quantitative assessment of body composition in cirrhosis. Diagnostics (Basel). 2024;14(19):2191

Article  PubMed  PubMed Central  Google Scholar 

Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017;23:625–633

Article  PubMed  PubMed Central  Google Scholar 

Mutalib SA, Mace M, Seager C, Burdet E, Mathiowetz V, Goldsmith N. Modernising grip dynamometry: Inter-instrument reliability between GripAble and Jamar. BMC Musculoskelet Disord. 2022;23(1):80

Article  PubMed  PubMed Central  Google Scholar 

Almashaqbeh SF, Al-Momani S, Khader A, Qananwah Q, Marabeh S, et al. The effect of gender and arm anatomical position on the hand grip strength and fatigue resistance during sustained maximal handgrip effort. J Biomed Phys Eng. 2022;12(2):171–180

PubMed  PubMed Central  Google Scholar 

Wang CW, Lebsack A, Chau S, Lai JC. The range and reproducibility of the liver frailty index. Liver Transpl. 2019;25(6):841–847

Article  PubMed  PubMed Central  Google Scholar 

Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, Macisaac RJ, Clarke S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab. 2008;93(5):1834–1840

Article  CAS  PubMed  Google Scholar 

Román E, García-Galcerán C, Torrades T, Herrera S, Marín A, Doñate M et al. Effects of an exercise programme on functional capacity, body composition and risk of falls in patients with cirrhosis: a randomized clinical trial. PLoS One. 2016;11(3):e0151652

Zenith L, Meena N, Ramadi A, Yavari M, Harvey A, Carbonneau M, et al. Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis. Clin Gastroenterol Hepatol. 2014;12(11):1920–6.e2

Article  PubMed  Google Scholar 

Berzigotti A, Albillos A, Villanueva C, Genescá J, Ardevol A, Augustín S, et al. Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: the SportDiet study. Hepatology. 2017;65(4):1293–1305

Article  PubMed  Google Scholar 

Macías-Rodríguez RU, Ilarraza-Lomelí H, Ruiz-Margáin A, Ponce-de-León-Rosales S, Vargas-Vorácková F, García-Flores O, et al. Changes in hepatic venous pressure gradient induced by physical exercise in cirrhosis: results of a pilot randomized open clinical trial. Clin Transl Gastroenterol. 2016;7(7): e180

Article  PubMed  PubMed Central  Google Scholar 

Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology. 2010;151(2):628–638

Article  CAS  PubMed  Google Scholar 

Kim G, Kang SH, Kim MY, Baik SK. Testosterone replacement therapy in men with liver cirrhosis: a systematic review and meta-analysis. World J Gastroenterol. 2019;25(36):5614–5627

Google Scholar 

Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017;23(5):625–633

Article  PubMed  PubMed Central  Google Scholar 

Belarmino G, Gonzalez MC, Sala P, Torrinhas RS, Andraus W, et al. Diagnosing sarcopenia in male patients with cirrhosis by dual-energy X-Ray absorptiometry estimates of appendicular skeletal muscle mass. JPEN J Parenter Enteral Nutr. 2018;42(1):24–36

Article  PubMed  Google Scholar 

Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Achacosa A, et al. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab. 2002;282(3):E601–E607

Article  CAS  PubMed  Google Scholar 

Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med. 1996;335(1):1–7

Article  CAS  PubMed  Google Scholar