Enhancing post-TIPS hepatic encephalopathy risk stratification: a hybrid TabPFN model leveraging radiomics, deep transfer learning features, and MELD score

Braillon A. Diagnosis and treatment of cirrhosis. JAMA. 2023;330:969

Article  PubMed  Google Scholar 

Ginès P, Krag A, Abraldes JG, et al. Liver cirrhosis. Lancet. 2021;398:1359–1376

Article  PubMed  Google Scholar 

Guixé-Muntet S, Quesada-Vázquez S, Gracia-Sancho J. Pathophysiology and therapeutic options for cirrhotic portal hypertension. Lancet Gastroenterol Hepatol. 2024;9:646–663

Article  PubMed  Google Scholar 

de Franchis R, Bosch J, Garcia-Tsao G, et al. Baveno VII - renewing consensus in portal hypertension. J Hepatol. 2022;76:959–974

Article  PubMed  Google Scholar 

EASL Clinical Practice Guidelines on TIPS. J Hepatol. 2025.

Tripathi D, Stanley AJ, Hayes PC, et al. Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension. Gut. 2020;69:1173–1192

Article  PubMed  Google Scholar 

Rose CF, Amodio P, Bajaj JS, et al. Hepatic encephalopathy: novel insights into classification, pathophysiology and therapy. J Hepatol. 2020;73:1526–1547

Article  PubMed  Google Scholar 

Wijdicks EF. Hepatic encephalopathy. N Engl J Med. 2016;375:1660–1670

Article  CAS  PubMed  Google Scholar 

Xu X, Yang Y, Tan X, et al. Hepatic encephalopathy post-TIPS: current status and prospects in predictive assessment. Comput Struct Biotechnol J. 2024;24:493–506

Article  PubMed  PubMed Central  Google Scholar 

Li X, Partovi S, Coronado WM, et al. Hepatic encephalopathy after TIPS placement: predictive factors, prevention strategies, and management. Cardiovasc Intervent Radiol. 2022;45:570–577

Article  PubMed  Google Scholar 

Huang EP, O’Connor JPB, McShane LM, et al. Criteria for the translation of radiomics into clinically useful tests. Nat Rev Clin Oncol. 2023;20:69–82

Article  PubMed  Google Scholar 

Zhang X, Zhang Y, Zhang G, et al. Prospective clinical research of radiomics and deep learning in oncology: a translational review. Crit Rev Oncol Hematol. 2022;179: 103823

Article  PubMed  Google Scholar 

Park HJ, Park B, Lee SS. Radiomics and deep learning: hepatic applications. Korean J Radiol. 2020;21:387–401

Article  PubMed  PubMed Central  Google Scholar 

Cheng S, Yu X, Chen X, et al. CT-based radiomics model for preoperative prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt. Br J Radiol. 2022;95: 20210792

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Huang M, Yu X, et al. Hepatic-associated vascular morphological assessment to predict overt hepatic encephalopathy before TIPS: a multicenter study. Hepatol Int. 2024;18:1238–1248

Article  PubMed  Google Scholar 

Cheng S, Hu G, Jin Z, et al. Prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt based on CT radiomic features of visceral adipose tissue. Acad Radiol. 2024;31:1849–1861

Article  PubMed  Google Scholar 

Tuifua TS, Kapoor B, Partovi S, et al. Prediction of mortality and hepatic encephalopathy after transjugular intrahepatic portosystemic shunt placement: baseline and longitudinal body composition measurement. J Vasc Interv Radiol. 2024;35:648-657.e641

Article  PubMed  Google Scholar 

Alatzides GL, Haubold J, Steinberg HL, et al. Adipopenia in body composition analysis: a promising imaging biomarker and potential predictive factor for patients undergoing transjugular intrahepatic portosystemic shunt placement. Br J Radiol. 2023;96: 20220863

Article  PubMed  PubMed Central  Google Scholar 

Hollmann N, Müller S, Purucker L, et al. Accurate predictions on small data with a tabular foundation model. Nature. 2025;637:319–326

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vilstrup H, Amodio P, Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology. 2014;60:715–735

Article  PubMed  Google Scholar 

Yin X, Zhang F, Guo H, et al. A nomogram to predict the risk of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in cirrhotic patients. Sci Rep. 2020;10:9381

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu XJ, Yin L, Zhu YJ, et al. Comparing efficacy of different scoring models to predict hepatic encephalopathy after TIPS in cirrhotic patients. Ann Med. 2025;57: 2514082

Article  PubMed  PubMed Central  Google Scholar 

Demirtas CO, D’Alessio A, Rimassa L, et al. ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma. JHEP Rep. 2021;3: 100347

Article  PubMed  PubMed Central  Google Scholar 

Hiraoka A, Kumada T, Michitaka K, et al. Newly proposed ALBI grade and ALBI-T score as tools for assessment of hepatic function and prognosis in hepatocellular carcinoma patients. Liver Cancer. 2019;8:312–325

Article  CAS  PubMed  Google Scholar 

Kim WR, Mannalithara A, Heimbach JK, et al. MELD 3.0: the model for end-stage liver disease updated for the modern era. Gastroenterology. 2021;161:1887–1895.e1884.

Mamone G, Comelli A, Porrello G, et al. Radiomics analysis of preprocedural CT imaging for outcome prediction after transjugular intrahepatic portosystemic shunt creation. Life. 2024. https://doi.org/10.3390/life14060726

Article  PubMed  PubMed Central  Google Scholar 

Vandaele R, Mukherjee P, Selby HM, et al. Topological data analysis of thoracic radiographic images shows improved radiomics-based lung tumor histology prediction. Patterns. 2023;4: 100657

Article  CAS  PubMed  Google Scholar 

Bureau C, Thabut D, Jezequel C, et al. The use of Rifaximin in the prevention of overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled trial. Ann Intern Med. 2021;174:633–640

Article  PubMed  Google Scholar 

Comments (0)

No login
gif