Sanyal AJ, Bosch J, Blei A, Arroyo V. Portal hypertension and its complications. Gastroenterology [Internet]. 2008;134:1715–1728
Chung C, Iwakiri Y. The lymphatic vascular system in liver diseases: its role in ascites formation. Clin Mol Hepatol [Internet]. 2013;19:99
Burchill MA, Goldberg AR, Tamburini BAJ. Emerging roles for lymphatics in chronic liver disease. Front Physiol. 2020;10:1579
PubMed PubMed Central Google Scholar
Iwakiri Y, Shah V, Rockey DC. Vascular pathobiology in chronic liver disease and cirrhosis—current status and future directions. J Hepatol [Internet]. 2014;61:912–924
Petrova TV, Koh GY. Biological functions of lymphatic vessels. Science [Internet] 2020;369. https://pubmed.ncbi.nlm.nih.gov/32646971/(cited 2021 Aug 14)
Lee Y, Zawieja SD, Muthuchamy M. Lymphatic collecting vessel: new perspectives on mechanisms of contractile regulation and potential lymphatic contractile pathways to target in obesity and metabolic diseases. Front Pharmacol [Internet]. 2022;13:848088
Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. Lymphatic vessel network structure and physiology. Compr Physiol. 2018;9:207–299
PubMed PubMed Central Google Scholar
Ohtani O, Ohtani Y. Lymph circulation in the liver. Anat Rec. 2008;291:643–652
Starling EH. Physiological factors involved in the causation of dropsy. Lancet 1896:1267–1270
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, et al. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Rep. 2024;6:101069
PubMed PubMed Central Google Scholar
Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, et al. Oxidized low-density lipoprotein drives dysfunction of the liver lymphatic system. Cell Mol Gastroenterol Hepatol. 2021;11:573–595
Bataller R, Brenner DA. Liver fibrosis. J Clin Invest [Internet]. 2005;115:209–218
Angus PW. Role of endothelin in systemic and portal resistance in cirrhosis. Gut [Internet]. 2006;55:1230
Kim MY, Baik SK, Lee SS. Hemodynamic alterations in cirrhosis and portal hypertension. Korean J Hepatol [Internet]. 2010;16:347
Dumont AE, Mulholland JH. Flow rate and composition of thoracic-duct lymph in patients with cirrhosis. N Engl J Med. 2010;263:471–474. https://doi.org/10.1056/NEJM196009082631001
Yamauchi Y, Michitaka K, Onji M. Morphometric analysis of lymphatic and blood vessels in human chronic viral liver diseases. Am J Pathol [Internet]. 1998;153:1131–1137
Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, et al. Oxidized low-density lipoprotein drives dysfunction of the liver lymphatic system. Cell Mol Gastroenterol Hepatol [Internet]. 2021;11:573–595
Yamauchi Y, Ikeda R, Michitaka K, Hiasa Y, Horiike N, Onji M, et al. Morphometric analysis of lymphatic vessels in primary biliary cirrhosis. Hepatol Res. 2002;24(2):107. https://doi.org/10.1016/s1386-6346(02)00019-0. (PMID: 12270739)
Tamburini BAJ, Finlon JM, Gillen AE, Kriss MS, Riemondy KA, Fu R, et al. Chronic liver disease in humans causes expansion and differentiation of liver lymphatic endothelial cells. Front Immunol. 2019;0:1036
Olkawa H, Masuda T, Sato SI, Yashima A, Suzuki K, Sato S, et al. Changes in lymph vessels and portal veins in the portal tract of patients with idiopathic portal hypertension: a morphometric study. Hepatology [Internet]. 1998;27:1607–1610
Zhang P, Li H, Zhou C, Liu K, Peng B, She X, et al. Single-cell RNA transcriptomics reveals the state of hepatic lymphatic endothelial cells in hepatitis B virus-related acute-on-chronic liver failure. J Clin Med [Internet]. 2022;11:2910
Montenegro-Navarro N, García-Báez C, García-Caballero M. Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology. Nat Commun. 2023;14:1–18
Colle I, Geerts AM, Van Steenkiste C, Van Vlierberghe H. Hemodynamic changes in splanchnic blood vessels in portal hypertension. Anat Rec Adv Integr Anat Evol Biol [Internet]. 2008;291:699–713. https://doi.org/10.1002/ar.20667
Iwakiri Y, Trebicka J. Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy. JHEP Rep [Internet]. 2021;3:100316
Barrowman JA, Granger DN. Effects of experimental cirrhosis on splanchnic microvascular fluid and solute exchange in the rat. Gastroenterology. 1984;87:165–172
Ribera J, Pauta M, Melgar-Lesmes P, Tugues S, Fernández-Varo G, Held KF, et al. Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats. Gut [Internet]. 2013;62:138–145
Ribera J, Pauta M, Melgar-Lesmes P, Tugues S, Fernández-Varo G, Held KF, et al. Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats. Gut. 2013;62(1):1
Hori N, Wiest R, Groszmann RJ. Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats. Hepatology [Internet]. 1998;28:1467–1473
Juneja P, Sharma A, Shasthry SM, Kumar G, Tripathi DM, Rajan V, et al. Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis. Front Physiol [Internet]. 2023;14:856. https://doi.org/10.3389/fphys.2023.1045983/full
Witte MH, Dumont AE, Cole WR, Witte CL, Kintner K. Lymph circulation in hepatic cirrhosis: effect of portacaval shunt. Ann Intern Med [Internet]. 1969;70:303–310
Verma SK, Mitchell DG, Bergin D, Lakhman Y, Austin A, Verma M, et al. Dilated cisternae chyli: a sign of uncompensated cirrhosis at MR imaging. Abdom Imaging [Internet]. 2009;34:211–216
Pieper CC, Feißt A, Meyer C, Luetkens J, Praktiknjo M, Trebicka J, et al. Impact of transjugular intrahepatic portosystemic shunt creation on the central lymphatic system in liver cirrhosis. Sci Rep [Internet] 2021;11. https://pubmed.ncbi.nlm.nih.gov/33782430/(cited 2024 Dec 26)
Yano R, Hirooka M, Koizumi Y, Nakamura Y, Imai Y, Morita M, et al. Lymphatic drainage dysfunction via narrowing of the lumen of cisterna chyli and thoracic duct after luminal dilation. Hepatol Int [Internet]. 2023;17:1557–1569
Ma R, Iwakiri Y. Lymphatic drainage dysfunction is related to clinically significant portal hypertension. Hepatol Int [Internet]. 2023;17:1327–1330. https://doi.org/10.1007/s12072-023-10592-z
Hirooka M, Koizumi Y, Yano R, Nakamura Y, Sunago K, Yukimoto A, et al. Cisterna chyli as an optimal marker of tolvaptan response in severe cirrhotic ascites. Sci Rep. 2022;12(1):8124. https://doi.org/10.1038/s41598-
Article CAS PubMed PubMed Central Google Scholar
Langford RJ, Daudia AT, Malins TJ. A morphological study of the thoracic duct at the jugulo-subclavian junction. J Cranio-Maxillo-Facial Surg. 1999;27:100–104
Ghelfi J, Brusset B, Thony F, Decaens T. Successful management of refractory ascites in non-TIPSable patients using percutaneous thoracic duct stenting. J Hepatol [Internet]. 2022;76:216–218
Ghelfi J, Brusset B, Teyssier Y, Sengel C, Gerster T, Girard E, et al. Endovascular lymphatic decompression via thoracic duct stent placement for refractory ascites in patients with cirrhosis: a pilot study. J Vasc Interv Radiol. 2023;34:212–217
Henriksen JH. Estimation of lymphatic conductance. A model based on protein-kinetic studies and haemodynamic measurements in patients with cirrhosis of the liver and in pigs. Scand J Clin Lab Investig [Internet]. 1985;45:123–130
Lenz K, Buder R, Voglmayr M, Kapun L. Treatment and management of ascites and hepatorenal syndrome: an update. Therap Adv Gastroenterol [Internet]. 2015;8:83
Kumar R, Anand U, Priyadarshi RN. Lymphatic dysfunction in advanced cirrhosis: contextual perspective and clinical implications. World J Hepatol [Internet]. 2021;13:300
Bhardwaj R, Vaziri H, Gautam A, Ballesteros E, Karimeddini D, Wu GY. Chylous ascites: a review of pathogenesis, diagnosis and treatment. J Clin Transl Hepatol [Internet]. 2017;6:105
Kumar R, Kumar T, Anand U, Priyadarshi RN. Intestinal lymphangiectasia associated with refractory ascites in a cirrhosis patient. Cureus [Internet] 2021;13. https://pubmed.ncbi.nlm.nih.gov/33564554/(cited 2024 Feb 9)
Deitch EA, Adams CA, Lu Q, Xu DZ. Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical
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