Novel Synthetic Kisspeptin Derivatives Impair Wound Healing in Breast Adenocarcinoma

Lee, J.H., Miele, M.E., Hicks, D.J., Phillips, K.K., Trent, J.M., Weissman, B.E., and Welch, D.R., KiSS‑1, a novel human malignant melanoma metastasis-suppressor gene, J. Natl. Cancer Inst., 1996, vol. 88, no. 23, pp. 1731–1737. https://doi.org/10.1093/jnci/88.23.1731

Article  CAS  PubMed  Google Scholar 

Miele, M.E., Jewett, M.D., Goldberg, S.F., Hyatt, D.L., Morelli, C., Gualandi, F., Rimessi, P., Hicks, D.J., Weissman, B.E., Barbanti-Brodano, G., and Welch, D.R., A human melanoma metastasis-suppressor locus maps to 6q16.3-q23, Int. J. Cancer, 2000, vol. 86, no. 4, pp. 524–528. https://doi.org/10.1002/(sici)1097-0215(20000515)86:4<524::aid-ijc13>3.0.co;2-w

Article  CAS  PubMed  Google Scholar 

Mead, E.J., Maguire, J.J., Kuc, R.E., and Davenport, A.P., Kisspeptins: A multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system, Br. J. Pharmacol., 2007, vol. 151, pp. 1143–1153. https://doi.org/10.1038/sj.bjp.0707295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolfe, A. and Hussain, M.A., The emerging role(s) for kisspeptin in metabolism in mammals, Front. Endocrinol. (Lausanne), 2018, vol. 9, p. 184. https://doi.org/10.3389/fendo.2018.00184

Article  Google Scholar 

Bhattacharya, M. and Babwah, A.V., Kisspeptin: Beyond the brain, Endocrinology, 2015, vol. 156, pp. 1218–1227. https://doi.org/10.1210/en.2014-1915

Article  CAS  PubMed  Google Scholar 

De Pedro, M.A., Moran, J., Díaz, I., et al., Circadian Kisspeptin expression in human term placenta, Placenta, 2015, vol. 36, pp. 1337–1339. https://doi.org/10.1016/j.placenta.2015.09.009

Article  CAS  PubMed  Google Scholar 

Wassie, T., Liu, G., Jiang, X., et al., Immunization against Kisspeptin-54 perturb hypothalamic–pituitary–testicular signaling pathway in ram lambs, Theriogenology, 2019, vol. 125, pp. 193–202. https://doi.org/10.1016/j.theriogenology.2018.10.029

Article  CAS  PubMed  Google Scholar 

Hu, K.L., Zhao, H., Chang, H.M., Yu, Y., and Qiao, J., Kisspeptin/kisspeptin receptor system in the ovary, Front. Endocrinol. (Lausanne), 2018, vol. 8, p. 365. https://doi.org/10.3389/fendo.2017.00365

Article  Google Scholar 

Song, W.J., Mondal, P., Wolfe, A., et al., Glucagon regulates hepatic kisspeptin to impair insulin secretion, Cell Metab., 2014, vol. 19, pp. 667–681. https://doi.org/10.1016/j.cmet.2014.03.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loosen, S.H., Luedde, M., Lurje, G., et al., Serum levels of Kisspeptin are elevated in patients with pancreatic cancer, Dis. Markers, 2019, vol. 2019, p. 5603474. https://doi.org/10.1155/2019/5603474

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohtaki, T., Shintani, Y., Honda, S., et al., Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor, Nature, 2001, vol. 411, pp. 613–617.

Article  CAS  PubMed  Google Scholar 

Sivalingam, M. and Parhar, I.S., Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours, Front. Neuroendocrinol., 2022, vol. 64, p. 100951. https://doi.org/10.1016/j.yfrne.2021.100951

Article  CAS  PubMed  Google Scholar 

Guzman, S., Brackstone, M., Radovick, S., Babwah, A.V., and Bhattacharya, M.M., KISS1/KISS1R in cancer: Friend or foe?, Front. Endocrinol. (Lausanne), 2018, vol. 9, p. 437. https://doi.org/10.3389/fendo.2018.00437

Article  Google Scholar 

Canbay, E., Ergen, A., Bugra, D., Yamaner, S., Eraltan, I.Y., Buyukuncu, Y., et al., Kisspeptin-54 levels are increased in patients with colorectal cancer, World J. Surg., 2012, vol. 36, no. 9, pp. 2218–2224. https://doi.org/10.1007/s00268-012-1636-7

Article  PubMed  Google Scholar 

Horstmann, M., Krause, F., Steinbach, D., Twelker, L., and Grimm, M.O., Evaluation of plasmatic Kisspetin-10 as a biomarker for malignancy and subtype differentiation in small renal tumours, Urol. Int., 2017, vol. 98, no. 2, pp. 177–183. https://doi.org/10.1159/000452108

Article  CAS  PubMed  Google Scholar 

Roseweir, A.K. and Millar, R.P., Kisspeptin antagonists, Adv. Exp. Med. Biol., 2013, vol. 784, pp. 159–186. https://doi.org/10.1007/978-1-4614-6199-9_8

Article  CAS  PubMed  Google Scholar 

Gutierrez-Pascual, E., Leprince, J., Martínez-Fuentes, A.J., et al., In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides, Mol. Pharmacol., 2009, vol. 76, no. 1, pp. 58–67. https://doi.org/10.1124/mol.108.053751

Article  CAS  PubMed  Google Scholar 

Orsini, M.J., Klein, M.A., Beavers, M.P., et al., Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening, J. Med. Chem., 2007, vol. 50, no. 3, pp. 462–471. https://doi.org/10.1021/jm0609824

Article  CAS  PubMed  Google Scholar 

Mead, E.J., Maguire, J.J., Kuc, R.E., and Davenport, A.P., Kisspeptins: A multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system, Br. J. Pharmacol., 2007, vol. 151, no. 8, pp. 1143–1153. https://doi.org/10.1038/sj.bjp.0707295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pfeil, E.M., Brands, J., Merten, N., Vögtle, T., Vescovo, M., Rick, U., Albrecht, I. M., Heycke, N., Kawakami, K., Ono, Y., Ngako Kadji, F.M., Hiratsuka, S., Aoki, J., Häberlein, F., Matthey, M., Garg, J., Hennen, S., Jobin, M. L., Seier, K., and Kostenis, E., Heterotrimeric G protein subunit Gαq is a master switch for Gβγ-mediated calcium mobilization by Gi-coupled GPCRs, Mol. Cell, 2020, vol. 80, no. 6, pp. 940–954. https://doi.org/10.1016/j.molcel.2020.10.027

Article  CAS  PubMed  Google Scholar 

Woll, K.A. and Van Petegem, F., Calcium-release channels: Structure and function of IP3 receptors and ryanodine receptors, Physiol. Rev., 2022, vol. 102, no. 1, pp. 209–268. https://doi.org/10.1152/physrev.00033.2020

Article  CAS  PubMed  Google Scholar 

Xie, Q., Kang, Y., Zhang, C., Xie, Y., Wang, C., Liu, J., Yu, C., Zhao, H., and Huang, D., The role of Kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction, Front. Endocrinol., 2022, vol. 13, p. 925206. https://doi.org/10.3389/fendo.2022.925206

Article  Google Scholar 

Liu, X. and Herbison, A.E., Kisspeptin regulation of neuronal activity throughout the central nervous system, Endocrinol. Metab., 2016, vol. 31, no. 2, p. 193. https://doi.org/10.3803/EnM.2016.31.2.193

Article  CAS  Google Scholar 

Sato, K., Shirai, R., Hontani, M., Shinooka, R., Hasegawa, A., Kichise, T., Yamashita, T., Yoshizawa, H., Watanabe, R., Matsuyama, T. A., Ishibashi-Ueda, H., Koba, S., Kobayashi, Y., Hirano, T., and Watanabe, T., Potent vasoconstrictor Kisspeptin-10 induces atherosclerotic plaque progression and instability: Reversal by its receptor GPR54 antagonist, J. Am. Heart Assoc., 2017, vol. 6, no. 4, p. e005790. https://doi.org/10.1161/JAHA.117.005790

Article  PubMed  PubMed Central  Google Scholar 

Dinh, H., Kovács, Z.Z.A., Márványkövi, F., Kis, M., Kupecz, K., Szűcs, G., Freiwan, M., Lauber, G. Y., Acar, E., Siska, A., Ibos, K. E., Bodnár, É., Kriston, A., Kovács, F., Horváth, P., Földesi, I., Cserni, G., Podesser, B. K., Pokreisz, P., and Sárközy, M., The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model, Sci. Rep., 2023, vol. 13, no. 1, p. 14046. https://doi.org/10.1038/s41598-023-41037-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu, C., Park, J.Y., Yun, M.W., He, Q.T., Yang, F., Kim, K., Ham, D., Li, R.R., Iverson, T.M., Gurevich, V.V., Sun, J.P., and Chung, K.Y., Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade, Proc. Natl. Acad. Sci. U. S. A., 2021, vol. 118, no. 37, p. e2026491118. https://doi.org/10.1073/pnas.2026491118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babwah, A.V., Pampillo, M., Min, L., Kaiser, U.B., and Bhattacharya, M., Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+, Endocrinology, 2012, vol. 153, no. 12, pp. 5875–5887. https://doi.org/10.1210/en.2012-1747

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif