Causal role of MiRNAs in chronic rhinosinusitis: mendelian randomization and validation study

Kim JH, Kim SH, Lim JY, Kim D, Jeong IS, Lee DK, et al. Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps. Exp Mol Med. 2020;52(6):978–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shin JM, Yang HW, Park JH, Kim TH. Role of nasal fibroblasts in airway remodeling of chronic rhinosinusitis: the modulating functions reexamined. Int J Mol Sci. 2023;24(4).

Toppila-Salmi S, Hällfors J, Aakko J, Mannerström B, Nieminen K, Telg G, et al. The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland. Clin Transl Allergy. 2022;12(10):e12200.

Article  PubMed  PubMed Central  Google Scholar 

Patel GB, Kern RC, Bernstein JA, Hae-Sim P, Peters AT. Current and future treatments of rhinitis and sinusitis. J Allergy Clin Immunol Pract. 2020;8(5):1522–31.

Article  PubMed  PubMed Central  Google Scholar 

van der Veen J, Seys SF, Timmermans M, Levie P, Jorissen M, Fokkens WJ, et al. Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre. Allergy. 2017;72(2):282–90.

Article  PubMed  Google Scholar 

Bu X, Wang M, Luan G, Wang Y, Wang C, Zhang L. Integrated MiRNA and mRNA expression profiling reveals dysregulated MiRNA-mRNA regulatory networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2021;11(8):1207–19.

Article  PubMed  Google Scholar 

Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843–54.

Article  CAS  PubMed  Google Scholar 

Bushati N, Cohen SM. MicroRNA functions. Annu Rev Cell Dev Biol. 2007;23:175–205.

Article  CAS  PubMed  Google Scholar 

Luan G, Wang M, Yuan J, Bu X, Wang Y, Ying S, et al. MicroRNA-21-5p promotes mucosal type 2 inflammation via regulating GLP1R/IL-33 signaling in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2022;150(6):1460–75.

Article  CAS  PubMed  Google Scholar 

Zhang XH, Zhang YN, Liu Z. MicroRNA in chronic rhinosinusitis and allergic rhinitis. Curr Allergy Asthma Rep. 2014;14(2):415.

Article  PubMed  Google Scholar 

Wu Y, Sun K, Tu Y, Li P, Hao D, Yu P, et al. miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway. Int Forum Allergy Rhinol. 2024;14(1):41–56.

Article  PubMed  Google Scholar 

Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, et al. An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. J Allergy Clin Immunol. 2020;145(2):550–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng J, Chen J, Zhao Y, Yang J, Xue K, Wang Z. MicroRNA-761 suppresses remodeling of nasal mucosa and epithelial-mesenchymal transition in mice with chronic rhinosinusitis through LCN2. Stem Cell Res Ther. 2020;11(1):151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Q, Wu R, Zhao M, Garcia-Gomez A, Ballestar E. MiRNAs as therapeutic targets in inflammatory disease. Trends Pharmacol Sci. 2019;40(11):853–65.

Article  CAS  PubMed  Google Scholar 

Tubita V, Callejas-Díaz B, Roca-Ferrer J, Marin C, Liu Z, Wang Y, et al. Role of MicroRNAs in inflammatory upper airway diseases. Allergy. 2021;76(7):1967–80.

Article  CAS  PubMed  Google Scholar 

Li J, Qiu CY, Tao YJ, Cheng L. Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps. Front Genet. 2022;13:1089647.

Article  CAS  PubMed  Google Scholar 

Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. MicroRNA-based therapeutics in central nervous system injuries. J Cereb Blood Flow Metab. 2018;38(7):1125–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richmond RC, Davey Smith G. Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med. 2022;12(1).

Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, et al. Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease. EBioMedicine. 2024;99:104934.

Article  CAS  PubMed  Google Scholar 

Shi G, Wu T, Li X, Zhao D, Yin Q, Zhu L. Systematic genome-wide Mendelian randomization reveals the causal links between MiRNAs and Parkinson’s disease. Front Neurosci. 2024;18:1385675.

Article  PubMed  PubMed Central  Google Scholar 

Zhu Y, Li M, He Z, Pang X, Du R, Yu W, et al. Evaluating the causal association between MicroRNAs and amyotrophic lateral sclerosis. Neurol Sci. 2023;44(10):3567–75.

Article  PubMed  Google Scholar 

Mu C, Dang X, Luo XJ. Mendelian randomization reveals the causal links between MicroRNA and schizophrenia. J Psychiatr Res. 2023;163:372–7.

Article  PubMed  Google Scholar 

Li C, Wu A, Song K, Gao J, Huang E, Bai Y et al. Identifying putative causal links between MicroRNAs and severe COVID-19 using Mendelian randomization. Cells. 2021;10(12).

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018;7.

Huan T, Rong J, Liu C, Zhang X, Tanriverdi K, Joehanes R, et al. Genome-wide identification of MicroRNA expression quantitative trait loci. Nat Commun. 2015;6:6601.

Article  CAS  PubMed  Google Scholar 

Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal Pleiotropy assumption. Int J Epidemiol. 2017;46(6):1985–98.

Article  PubMed  PubMed Central  Google Scholar 

Xia K, Zhang L, Tang L, Huang T, Fan D. Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study. Orphanet J Rare Dis. 2022;17(1):56.

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal Pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greco MF, Minelli C, Sheehan NA, Thompson JR. Detecting Pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med. 2015;34(21):2926–40.

Article  Google Scholar 

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect Estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–64.

Article  PubMed  Google Scholar 

Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(Suppl S29):1–464.

PubMed  Google Scholar 

Chang L, Zhou G, Soufan O, Xia J. MiRNet 2.0: network-based visual analytics for MiRNA functional analysis and systems biology. Nucleic Acids Res. 2020;48(W1):W244–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Welp AL, Bomberger JM. Bacterial community interactions during chronic respiratory disease. Front Cell Infect Microbiol. 2020;10:213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Sun Y, Bai W. The role of epigenetics in the chronic sinusitis with nasal polyp. Curr Allergy Asthma Rep. 2020;21(1):1.

Article  PubMed 

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