Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.

Article  PubMed  Google Scholar 

Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Pancreatic cancer: Advances and challenges. Cell. 2023;186:1729–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang W, Hu X, He X, Pan D, Huang Z, Gu Z, et al. TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC. Drug Resist Updat. 2024;74:101079.

Article  CAS  PubMed  Google Scholar 

Maitra A, Topol EJ. Early detection of pancreatic cancer and AI risk partitioning. Lancet. 2024;403:1438.

Article  PubMed  Google Scholar 

Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet. 2020;395:2008–20.

Article  CAS  PubMed  Google Scholar 

Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2023;41:4714–20.

Article  CAS  PubMed  Google Scholar 

Xu X, Fang Y, Nowsheen S, Li YX, Lou Z, Deng M. Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer. Genes Dis. 2024;11:101035.

Article  CAS  PubMed  Google Scholar 

Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 2010;50:355–75.

Article  CAS  PubMed  Google Scholar 

Dustin ML, Bivona TG, Philips MR. Membranes as messengers in T cell adhesion signaling. Nat Immunol. 2004;5:363–72.

Article  CAS  PubMed  Google Scholar 

Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, et al. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004;7:585–95.

Article  CAS  PubMed  Google Scholar 

Hilbi H, Kortholt A. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection. Small GTPases. 2019;10:336–42.

Article  CAS  PubMed  Google Scholar 

Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, et al. Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nat Commun. 2015;6:5917.

Article  CAS  PubMed  Google Scholar 

Li Z, Xu C, Ding B, Gao M, Wei X, Ji N. Long non-coding RNA MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101. J Neurooncol. 2017;134:19–28.

Article  CAS  PubMed  Google Scholar 

Fan M, Ma X, Wang F, Zhou Z, Zhang J, Zhou D, et al. MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b. Cancer Lett. 2020;477:144–56.

Article  CAS  PubMed  Google Scholar 

Zhou B, Xu J, Chen Y, Gao S, Feng X, Lu X. miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-kappaB/Twist1 pathway. Exp Cell Res. 2020;387:111785.

Article  CAS  PubMed  Google Scholar 

Tang Z, Peng H, Chen J, Liu Y, Yan S, Yu G, et al. Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1. Exp Cell Res. 2018;367:56–64.

Article  CAS  PubMed  Google Scholar 

She X, Yu Z, Cui Y, Lei Q, Wang Z, Xu G, et al. miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells. Med Oncol. 2014;31:892.

Article  PubMed  Google Scholar 

Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, et al. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep. 2023;42:112316.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bei Y, Cheng N, Chen T, Shu Y, Yang Y, Yang N, et al. CDK5 Inhibition Abrogates TNBC Stem-Cell Property and Enhances Anti-PD-1 Therapy. Adv Sci. 2020;7:2001417.

Article  CAS  Google Scholar 

Song Z, Feng C, Lu Y, Lin Y, Dong C. PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer. Gene. 2018;642:43–50.

Article  CAS  PubMed  Google Scholar 

Song Z, Li J, Zhang L, Deng J, Fang Z, Xiang X, Xiong J. UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization. Am J Cancer Res. 2019;9:1970–81.

CAS  PubMed  PubMed Central  Google Scholar 

Yan Y, Xu Z, Huang J, Guo G, Gao M, Kim W, et al. The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization. Nucleic Acids Res. 2020;48:12711–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224.

Article  PubMed  PubMed Central  Google Scholar 

Meng Y, Guo D, Lin L, Zhao H, Xu W, Luo S, et al. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance beta-oxidation and tumor cell proliferation. Nat Metab. 2024;6:1092–107.

Article  CAS  PubMed  Google Scholar 

Manley SJ, Olou AA, Jack JL, Ruckert MT, Walsh RM, Eades AE, et al. Synthetic adiponectin-receptor agonist, AdipoRon, induces glycolytic dependence in pancreatic cancer cells. Cell Death Dis. 2022;13:114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369:1691–703.

Article  Google Scholar 

Nguyen CDK, Colon-Emeric BA, Murakami S, Shujath MNY, Yi C. PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer. Cell Rep. 2024;43:114176.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feldmann G, Mishra A, Hong SM, Bisht S, Strock CJ, Ball DW, et al. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. Cancer Res. 2010;70:4460–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan T, Li M, Song Y, Chen J, Tang J, Zhang C, et al. Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions. Adv Sci. 2023;10:e2205873.

Article  Google Scholar 

Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, et al. Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer. Cancer Cell. 2024;42:662–681.e610.

Article  PubMed  Google Scholar 

Li C, Gao Z, Cui Z, Liu Z, Bian Y, Sun H, et al. Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours. Oncogene. 2023;42:894–910.

Article  CAS  PubMed  Google Scholar