SCI Abstract

search
+
Functional deficiency of circadian regulator PER2 enhances breast cancer susceptibility and progression with immunosuppression
Functional deficiency of circadian regulator PER2 enhances breast cancer susceptibility and progression with immunosuppression
Circadian rhythm (CR) governs systemic and tissue physiological homeostasis by regulating sleep-wake cycles, hormone secre...
Inhibition of PINK1/Parkin-mediated mitophagy enhances the susceptibility of breast cancer to cuproptosis
Inhibition of PINK1/Parkin-mediated mitophagy enhances the susceptibility of breast cancer to cuproptosis
Cuproptosis is a novel form of programmed cell death characterized by the accumulation of copper ions in the mitochondria,...
Imbalanced p53–RB signaling triggers cGAS–STING–mediated immune activation in early oral cancer development
Imbalanced p53–RB signaling triggers cGAS–STING–mediated immune activation in early oral cancer development
Combined alterations of TP53 and CDKN2A are frequently observed in head and neck squamous cell carcinoma (HNSCC); however,...
The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow
The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow
Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal ...
Tumor-derived PTX3 drives an immunosuppressive myeloid landscape and inhibits CD8 T cell-mediated anti-tumor immunity via PI3K-dependent signaling
Tumor-derived PTX3 drives an immunosuppressive myeloid landscape and inhibits CD8 T cell-mediated anti-tumor immunity via PI3K-dependent signaling
Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), has emerged as a pillar of modern oncology. Howeve...
PTEN-AKT2 regulates mixed lineage liver cancer development and sensitizes cancer cells to TGFβ treatment
PTEN-AKT2 regulates mixed lineage liver cancer development and sensitizes cancer cells to TGFβ treatment
Primary liver cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), arise from the neoplastic tr...
Cholangiocarcinoma:Unveiling the cold tumor microenvironment and strategies for immune rejuvenation
Cholangiocarcinoma:Unveiling the cold tumor microenvironment and strategies for immune rejuvenation
Cholangiocarcinoma (CCA) remains a therapeutic challenge due to its “immune cold” phenotype, defined by a desm...
Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1
Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1
Although chemotherapy in colorectal cancer (CRC) primarily targets epithelial tumor cells, the epithelial cell-intrinsic m...
IRF2BPL transcriptionally regulates IGFBP2 to promote tumor progression and suppresses immune cell infiltration in esophageal squamous cell carcinoma
IRF2BPL transcriptionally regulates IGFBP2 to promote tumor progression and suppresses immune cell infiltration in esophageal squamous cell carcinoma
Numerous ubiquitination-related proteases (URPs) have been identified as facilitators of disease progression through the d...
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
The USP37 gene encodes a deubiquitylase (DUB), which catalyzes the proteolytic removal of ubiquitin moieties from proteins...
LAMP1 enhances DNA-PKcs-mediated AKT phosphorylation and VEGFC secretion to promote lymph node metastasis in esophageal squamous cell carcinoma
LAMP1 enhances DNA-PKcs-mediated AKT phosphorylation and VEGFC secretion to promote lymph node metastasis in esophageal squamous cell carcinoma
Lymph node metastasis (LNM) is a major determinant of poor prognosis in esophageal squamous cell carcinoma (ESCC), with pa...
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients
Metastatic breast cancer (MBC) is generally an incurable neoplasm. A small cohort of patients with HER2-positive MBC, howe...
NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair
NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair
RNA modification recognition proteins are crucial in cancer development and progression. Among all RNA modification-relate...
PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
Indolent lung cancer is characterized by slow progression, and the patient may die of other causes before it becomes sympt...
The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer
The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer
Activating mutations in the ligand-binding domain of the estrogen receptor (ER)-encoding (ESR1) gene are present in up to ...
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
While Stimulator-of-interferon genes (STING) is an innate immune adapter crucial for sensing cytosolic DNA and modulating ...
Retraction Note: MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway
Cite this articleDeng, L., Tang, J., Yang, H. et al. Retraction Note: MTA1 modulated by miR-30e contributes to epithelial-...
Correction: TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression
Correction: TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression
Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, ChinaCai...
Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma
Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma
Derlin-3 has been implicated as an essential element in the degradation of misfolded lumenal glycoproteins induced by endo...
Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability
Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma
Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal human cancer. Gemcitabine-based chemotherapy remains the corner...
GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
TP53 mutations are common in breast cancer (BC) and are associated with poor prognosis. GD3 synthase (GD3S/ST8SIA1), a gen...
Erk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop
Erk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop
The receptor tyrosine kinase (RTK)-Ras-Raf-MEK-Erk cascade is frequently mutated in cancer, but it is not known whether Er...
A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway
A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway
Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the acti...
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USAShoumin Zhu, Mohammed Soutto, Zheng Ch...
ROS production by mitochondria: function or dysfunction?
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions....
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies hav...
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of c...
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor prognosis due to a lack of early detecti...
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression prog...
Load More
format_indent_increase