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IRF2BPL transcriptionally regulates IGFBP2 to promote tumor progression and suppresses immune cell infiltration in esophageal squamous cell carcinoma
IRF2BPL transcriptionally regulates IGFBP2 to promote tumor progression and suppresses immune cell infiltration in esophageal squamous cell carcinoma
Numerous ubiquitination-related proteases (URPs) have been identified as facilitators of disease progression through the d...
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
The USP37 gene encodes a deubiquitylase (DUB), which catalyzes the proteolytic removal of ubiquitin moieties from proteins...
LAMP1 enhances DNA-PKcs-mediated AKT phosphorylation and VEGFC secretion to promote lymph node metastasis in esophageal squamous cell carcinoma
LAMP1 enhances DNA-PKcs-mediated AKT phosphorylation and VEGFC secretion to promote lymph node metastasis in esophageal squamous cell carcinoma
Lymph node metastasis (LNM) is a major determinant of poor prognosis in esophageal squamous cell carcinoma (ESCC), with pa...
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients
Metastatic breast cancer (MBC) is generally an incurable neoplasm. A small cohort of patients with HER2-positive MBC, howe...
NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair
NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair
RNA modification recognition proteins are crucial in cancer development and progression. Among all RNA modification-relate...
PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
Indolent lung cancer is characterized by slow progression, and the patient may die of other causes before it becomes sympt...
The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer
The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer
Activating mutations in the ligand-binding domain of the estrogen receptor (ER)-encoding (ESR1) gene are present in up to ...
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
While Stimulator-of-interferon genes (STING) is an innate immune adapter crucial for sensing cytosolic DNA and modulating ...
Retraction Note: MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway
Cite this articleDeng, L., Tang, J., Yang, H. et al. Retraction Note: MTA1 modulated by miR-30e contributes to epithelial-...
Correction: TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression
Correction: TP53 mutations upregulate RCP expression via Sp1/3 to drive lung cancer progression
Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, ChinaCai...
Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma
Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma
Derlin-3 has been implicated as an essential element in the degradation of misfolded lumenal glycoproteins induced by endo...
Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability
Correction: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma
Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal human cancer. Gemcitabine-based chemotherapy remains the corner...
GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
TP53 mutations are common in breast cancer (BC) and are associated with poor prognosis. GD3 synthase (GD3S/ST8SIA1), a gen...
Erk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop
Erk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop
The receptor tyrosine kinase (RTK)-Ras-Raf-MEK-Erk cascade is frequently mutated in cancer, but it is not known whether Er...
A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway
A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway
Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the acti...
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USAShoumin Zhu, Mohammed Soutto, Zheng Ch...
ROS production by mitochondria: function or dysfunction?
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions....
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies hav...
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of c...
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor prognosis due to a lack of early detecti...
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression prog...
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
Reprogramming of lipid metabolism during hepatocarcinogenesis is not well elucidated. Here, we aimed to explore pivotal RN...
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits...
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Klotho, a 1012 amino acid transmembrane protein, is a potent tumor suppressor in different cancer types. Klotho is compose...
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling. Although there has been substantia...
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Dendritic cells (DCs) play critical roles in recognizing and presenting antigens to T cells. They secrete dendritic cell-d...
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effec...
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitute...
PRAME induces genomic instability in uveal melanoma
PRAME induces genomic instability in uveal melanoma
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in ...
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