Adams SJ, Stone E, Baldwin DR, Vliegenthart R, Lee P, Fintelmann FJ. Lung cancer screening. Lancet. 2023;401:390–408.

Article  PubMed  Google Scholar 

Leiter A, Veluswamy RR, Wisnivesky JP. The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol. 2023;20:624–39.

Article  PubMed  Google Scholar 

Crosby D, Bhatia S, Brindle KM, Coussens LM, Dive C, Emberton M, et al. Early detection of cancer. Science. 2022;375:eaay9040.

Article  CAS  PubMed  Google Scholar 

Walsh RJ, Soo RA. Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies. Ther Adv Med Oncol. 2020;12:1758835920937902.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Visser KE, Joyce JA. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41:374–403.

Article  PubMed  Google Scholar 

Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.

Article  CAS  PubMed  Google Scholar 

Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression. Science. 2020;368:eaaw5473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klemm F, Joyce JA. Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol. 2015;25:198–213.

Article  PubMed  Google Scholar 

De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017;17:457–74.

Article  PubMed  Google Scholar 

Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol. 2012;30:221–41.

Article  CAS  PubMed  Google Scholar 

Krumbholz M, Derfuss T, Hohlfeld R, Meinl E. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol. 2012;8:613–23.

Article  CAS  PubMed  Google Scholar 

Matsushita T. Regulatory and effector B cells: Friends or foes?. J Dermatol Sci. 2019;93:2–7.

Article  CAS  PubMed  Google Scholar 

Yuen GJ, Demissie E, Pillai S. B lymphocytes and cancer: a love-hate relationship. Trends Cancer. 2016;2:747–57.

Article  PubMed  PubMed Central  Google Scholar 

Cubillos-Ruiz JR, Bettigole SE, Glimcher LH. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell. 2017;168:692–706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salvagno C, Mandula JK, Rodriguez PC, Cubillos-Ruiz JR. Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity. Trends Cancer. 2022;8:930–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Csordás G, Weaver D, Hajnóczky G. Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions. Trends Cell Biol. 2018;28:523–40.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Shi C, He M, Xiong S, Xia X. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther. 2023;8:352.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song S, Tan J, Miao Y, Zhang Q. Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery. J Cell Physiol. 2018;233:3867–74.

Article  CAS  PubMed  Google Scholar 

Wiseman RL, Mesgarzadeh JS, Hendershot LM. Reshaping endoplasmic reticulum quality control through the unfolded protein response. Mol Cell. 2022;82:1477–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Urra H, Dufey E, Avril T, Chevet E, Hetz C. Endoplasmic reticulum stress and the hallmarks of cancer. Trends Cancer. 2016;2:252–62.

Article  PubMed  Google Scholar 

Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol. 2006;172:383–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Liu H, Chen H, Shao J, Su F, Zhang S, et al. DERL3 functions as a tumor suppressor in gastric cancer. Comput Biol Chem. 2020;84:107172.

Article  CAS  PubMed  Google Scholar 

Geng M, Xu K, Meng L, Xu J, Jiang C, Guo Y, et al. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. Clin Immunol. 2020;220:108579.

Article  CAS  PubMed  Google Scholar 

Lin L, Lin G, Lin H, Chen L, Chen X, Lin Q, et al. Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma. Front Immunol. 2022;13:906420.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Cui X, Sun D, Sun G, Yan Z, Wei M, et al. POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6. Cell Death Dis. 2023;14:802.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu F, Fan J, He Y, Xiong A, Yu J, Li Y, et al. Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat Commun. 2021;12:2540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mishra M, Jiang H, Chawsheen HA, Gerard M, Toledano MB, Wei Q. Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis. Cancer Lett. 2018;432:216–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Liu G, Ha DP, Wang J, Xiong M, Lee AS. ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator. Proc Natl Acad Sci USA. 2023;120:e2303448120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abisambra JF, Jinwal UK, Blair LJ, O’Leary JC 3rd, Li Q, Brady S, et al. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci. 2013;33:9498–507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang J, Qi L. Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. Trends Biochem Sci. 2018;43:593–605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Huang T, Hammarström L, Zhao Y. The Immunoglobulins: New Insights, Implications, and Applications. Annu Rev Anim Biosci. 2020;8:145–69.