Fitz-James MH, Cavalli G. Molecular mechanisms of transgenerational epigenetic inheritance. Nat Rev Genet. 2022;23:325–41.

Article  CAS  PubMed  Google Scholar 

Henning AN, Roychoudhuri R, Restifo NP. Epigenetic control of CD8⁺ T cell differentiation. Nat Rev Immunol. 2018;18:340–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pal S, Tyler JK. Epigenetics and aging. Sci Adv. 2016;2:e1600584.

Article  PubMed  PubMed Central  Google Scholar 

Xue C, Chu Q, Zheng Q, Jiang S, Bao Z, Su Y, et al. Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine. Signal Transduct Target Ther. 2022;7:142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng W, Li J, Chen R, Gu Q, Yang P, Qian W, et al. Upregulated METTL3 promotes metastasis of colorectal cancer via miR-1246/SPRED2/MAPK signaling pathway. J Exp Clin Cancer Res. 2019;38:1–16.

Article  Google Scholar 

Sun Y, Li S, Yu W, Zhao Z, Gao J, Chen C, et al. N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020;11:836.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiang Y, Laurent B, Hsu C, Nachtergaele S, Lu Z, Sheng W, et al. RNA m6A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017;543:573–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sikorski V, Selberg S, Lalowski M, Karelson M, Kankuri E. The structure and function of YTHDF epitranscriptomic m⁶A readers. Trends Pharm Sci. 2023;44:335–53.

Article  CAS  PubMed  Google Scholar 

Patel SG, Karlitz JJ, Yen T, Lieu CH, Boland CR. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection. Lancet Gastroenterol Hepatol. 2022;7:262–74.

Article  CAS  PubMed  Google Scholar 

Mauri G, Arena S, Siena S, Bardelli A, Sartore-Bianchi A. The DNA damage response pathway as a land of therapeutic opportunities for colorectal cancer. Ann Oncol. 2020;31:1135–47.

Article  CAS  PubMed  Google Scholar 

Yang X, Zhang S, He C, Xue P, Zhang L, He Z, et al. METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST. Mol Cancer. 2020;19:1–16.

Article  Google Scholar 

Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, et al. Acetylation of cytidine in mRNA promotes translation efficiency. Cell. 2018;175:1872–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin C, Wang T, Zhang D, Yang P, Zhang C, Peng W, et al. Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA. J Exp Clin Cancer Res. 2022;41:345.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014;344:527–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinf. 2008;9:559.

Article  Google Scholar 

Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, et al. Promoter-bound METTL3 maintains myeloid leukaemia by m⁶A-dependent translation control. Nature. 2017;552:126–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Crécy-Lagard V, Boccaletto P, Mangleburg CG, Sharma P, Lowe TM, Leidel SA, et al. Matching tRNA modifications in humans to their known and predicted enzymes. Nucleic Acids Res. 2019;47:2143–59.

Article  PubMed  PubMed Central  Google Scholar 

Bartha Á, Győrffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci. 2021;22:2622.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BV, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19:649–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair. 2008;7:1765–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang J, Tang Q, He J, Li L, Yang N, Yu S, et al. RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility. Nucleic Acids Res. 2022;50:D326–D332.

Article  CAS  PubMed  Google Scholar 

Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556–W560.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Hao Y, Liu Y, Zhong S, You Y, Ao K, et al. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer. Adv Sci. 2023;10:2302705.

Article  CAS  Google Scholar 

Wei R, Cui X, Min J, Lin Z, Zhou Y, Guo M, et al. NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma. Acta Pharm Sin B. 2022;12:3313–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan S, Lu Z, Yang W, Xu J, Wang Y, Xiong W, et al. Antibody-free fluorine-assisted metabolic sequencing of RNA N4-acetylcytidine. J Am Chem Soc. 2023;145:22232–42.

Article  CAS  PubMed  Google Scholar 

Zhao W, Zhou Y, Cui Q, Zhou Y. PACES: prediction of N4-acetylcytidine (ac4C) modification sites in mRNA. Sci Rep. 2019;9:1027.

Google Scholar 

Thomas JM, Briney CA, Nance KD, Lopez JE, Thorpe AL, Fox SD, et al. A chemical signature for cytidine acetylation in RNA. J Am Chem Soc. 2018;140:12667–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Y, Chen Z, Xie G, Zhang H, Wang Z, Zhou J, et al. RNA m1A methylation regulates glycolysis of cancer cells through modulating ATP5D. Proc Natl Acad Sci USA. 2022;119:e2119038119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, et al. The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discov. 2021;11:480–99.

Article  CAS  PubMed  Google Scholar 

Zheng Q, Gan H, Yang F, Yao Y, Hao F, Hong L, et al. Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m¹A-methylated IGF1R. Cell Discov. 2020;6:12.

Article  CAS  PubMed  PubMed Central  Google Scholar