Khosravi GR, Mostafavi S, Bastan S, Ebrahimi N, Gharibvand RS, Eskandari N. Immunologic tumor microenvironment modulators for turning cold tumors hot. Cancer Commun. 2024;44:521–53.
Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 2019;18:197–218.
Article CAS PubMed Google Scholar
Benoit A, Vogin G, Duhem C, Berchem G, Janji B. Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy. Cells. 2023;12:1787.
Article CAS PubMed PubMed Central Google Scholar
Nie J, Zhang S, Guo Y, Liu C, Shi J, Wu H, et al. Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity. Cancer Res. 2025;85:704–22.
Article CAS PubMed Google Scholar
Liu C, Wang X, Liu E, Zong Y, Yu W, Jiang Y, et al. Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution. J Hematol Oncol. 2025;18:66.
Article PubMed PubMed Central Google Scholar
Duffy AG, Makarova-Rusher OV, Greten TF. The case for immune-based approaches in biliary tract carcinoma. Hepatology. 2016;64:1785–91.
Article PubMed PubMed Central Google Scholar
Kim HD, Kim JH, Ryu YM, Kim D, Lee S, Shin J, et al. Spatial Distribution and Prognostic Implications of Tumor-Infiltrating FoxP3- CD4+ T Cells in Biliary Tract Cancer. Cancer Res Treat. 2021;53:162–71.
Article CAS PubMed Google Scholar
Martin-Serrano MA, Kepecs B, Torres-Martin M, Bramel ER, Haber PK, Merritt E, et al. Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications. Gut. 2023;72:736–48.
Article CAS PubMed Google Scholar
Darman L, Kaurich Q, Hassan MS, von Holzen U, Awasthi N. Expanding Horizons in Cholangiocarcinoma: Emerging Targets Beyond FGFR2 and IDH1. Int J Mol Sci. 2025;26:10755.
Article CAS PubMed PubMed Central Google Scholar
Javle M, Bekaii-Saab T, Jain A, Wang Y, Kelley RK, Wang K, et al. Biliary cancer: Utility of next-generation sequencing for clinical management. Cancer. 2016;122:3838–47.
Article CAS PubMed Google Scholar
Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, et al. Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov. 2017;7:1116–35.
Article CAS PubMed PubMed Central Google Scholar
Sasaki M, Sato Y, Nakanuma Y. Genetic re-classification of combined hepatocellular-cholangiocarcinoma and small duct type intrahepatic cholangiocarcinoma. Pathol Res Pr. 2025;270:155999.
Chen Z, Gao J, Li Z, Ma D, Wang Y, Cheng Q, et al. Integrative analysis reveals different feature of intrahepatic cholangiocarcinoma subtypes. Liver Int. 2024;44:2477–93.
Article CAS PubMed Google Scholar
Jeong H, Oh JH, Ahn HS, Ryoo BY, Kim KP, Jeong JH, et al. Proteogenomic profiling predicts outcomes of adjuvant chemotherapy in extrahepatic cholangiocarcinoma. J Hepatol. 2026;84:122–34.
Article CAS PubMed Google Scholar
Quinn LM, Haldenby S, Antzcak P, Fowler A, Bullock K, Kenny J, et al. Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways. Sci Rep. 2023;13:6681.
Article CAS PubMed PubMed Central Google Scholar
Burr ML, Sparbier CE, Chan KL, Chan YC, Kersbergen A, Lam EYN, et al. An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell. 2019;36:385–401. e8.
Article CAS PubMed PubMed Central Google Scholar
Kinoshita M, Sato Y, Kubo S, Shinkawa H, Kimura K, Nishio K, et al. Subclassification-Specific Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Implications for Appropriate Pharmacotherapy. Cancers. 2025;17:2082.
Article CAS PubMed PubMed Central Google Scholar
Lin J, Dai Y, Sang C, Song G, Xiang B, Zhang M, et al. Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities. J Immunother Cancer. 2022;10:e004892.
Article PubMed PubMed Central Google Scholar
Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The complex role of tumor-infiltrating macrophages. Nat Immunol. 2022;23:1148–56.
Article CAS PubMed PubMed Central Google Scholar
Li C, Xu X, Wei S, Jiang P, Xue L, Wang J. Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer. J Immunother Cancer. 2021;9:e001341.
Article PubMed PubMed Central Google Scholar
Tu J, Wu F, Chen L, Zheng L, Yang Y, Ying X, et al. Long Non-Coding RNA PCAT6 Induces M2 Polarization of Macrophages in Cholangiocarcinoma via Modulating miR-326 and RhoA-ROCK Signaling Pathway. Front Oncol. 2020;10:605877.
Qian Y, Yao W, Yang T, Yang Y, Liu Y, Shen Q, et al. aPKC-ι/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma. Hepatology. 2017;66:1165–82.
Article CAS PubMed Google Scholar
Yang Y, Liu Y, He JC, Wang JM, Schemmer P, Ma CQ, et al. 14-3-3ζ and aPKC-ι synergistically facilitate epithelial-mesenchymal transition of cholangiocarcinoma via GSK-3β/Snail signaling pathway. Oncotarget. 2016;7:55191–210.
Article PubMed PubMed Central Google Scholar
Yang T, Deng Z, Xu L, Li X, Yang T, Qian Y, et al. Macrophages-aPKC(ɩ)-CCL5 Feedback Loop Modulates the Progression and Chemoresistance in Cholangiocarcinoma. J Exp Clin Cancer Res. 2022;41:23.
Article CAS PubMed PubMed Central Google Scholar
Guo Y, Miao S, Jin Y, Li Q, Wang Y, Zhang X, et al. Tumor-associated macrophages contribute to cholangiocarcinoma progression and chemoresistance through activation of ID1. Ann Hepatol. 2024;30:101773.
Zhao Z, Chen C, Wu W, Wang F, Du L, Zhang X, et al. Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles. Nat Commun. 2019;10:768.
Article CAS PubMed PubMed Central Google Scholar
Chen F, Sheng J, Li X, Gao Z, Hu L, Chen M, et al. Tumor-associated macrophages: orchestrators of cholangiocarcinoma progression. Front Immunol. 2024;15:1451474.
Article CAS PubMed PubMed Central Google Scholar
Ma QX, Zhao R, Han JX, Zhu WY, Xu MD, Zhang XY, et al. Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity. Nat Immunol. 2026;27:1169–83.
Article CAS PubMed Google Scholar
Antuamwine BB, Bosnjakovic R, Hofmann-Vega F, Wang X, Theodosiou T, Iliopoulos I, et al. N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology. Immunol Rev. 2023;314:250–79.
Article CAS PubMed Google Scholar
Sun Q, Lei X, Meng X, Zha C, Yan L, Zhang W. Bioinformatics analysis identifies WNK1 gene as a potential biomarker for cholangiocarcinoma diagnosis and immune infiltration. J Genet Eng Biotechnol. 2024;22:100426.
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