Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol 2022;95. https://doi.org/10.1259/BJR.20211033.

Pu CC, Yin L, Yan JM. Risk factors and survival prediction of young breast cancer patients with liver metastases: a population-based study. Front Endocrinol 2023; 14. https://doi.org/10.3389/fendo.2023.1158759.

Merenbakh-Lamin K, Ben-Baruch N, Yeheskel A, Dvir A, Soussan-Gutman L, Jeselsohn R, et al. D538G mutation in estrogen receptor-α: A novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res. 2013;73:6856–64.

Article  PubMed  CAS  Google Scholar 

Zinger L, Merenbakh-Lamin K, Klein A, Elazar A, Journo S, Boldes T, et al. Ligand-binding domain–activating mutations of ESR1 rewire cellular metabolism of breast cancer cells. Clin Cancer Res. 2019;25:2900–14. https://doi.org/10.1158/1078-0432.ccr-18-1505.

Article  PubMed  CAS  Google Scholar 

Pegram M, Jackisch C, Johnston SRD. Estrogen/HER2 receptor crosstalk in breast cancer: combination therapies to improve outcomes for patients with hormone receptor-positive/HER2-positive breast cancer. npj Breast Cancer. 2023;9:45. https://doi.org/10.1038/s41523-023-00533-2.

Article  PubMed  PubMed Central  Google Scholar 

Jeselsohn R, Yelensky R, Buchwalter G, Frampton G, Meric-Bernstam F, Gonzalez-Angulo AM, et al. Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res. 2014;20:1757–67.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jeselsohn R, Buchwalter G, De Angelis C, Brown M, Schiff R. ESR1 mutations-a mechanism for acquired endocrine resistance in breast cancer. Nat Rev Clin Oncol. 2015;12:573–83. https://doi.org/10.1038/nrclinonc.2015.117.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chandarlapaty S, Chen D, He W, Sung P, Samoila A, You D, et al. Prevalence of ESR1 mutations in cell-free DNA and Outcomes in Metastatic Breast Cancer. JAMA Oncol. 2016;2:1310. https://doi.org/10.1001/jamaoncol.2016.1279.

Article  PubMed  PubMed Central  Google Scholar 

Reinert T, Coelho GP, Mandelli J, Zimermann E, Zaffaroni F, Bines J, et al. Association of ESR1 mutations and visceral metastasis in patients with estrogen receptor-positive advanced breast cancer from Brazil. J Oncol. 2019;2019:1–5. https://doi.org/10.1155/2019/1947215.

Article  CAS  Google Scholar 

Wu Y, Li Z, Lee AV, Oesterreich S, Luo B. Liver tropism of ER mutant breast cancer is characterized by unique molecular changes and immune infiltration. Breast Cancer Res Treat. 2024;205:371–86. https://doi.org/10.1007/s10549-024-07255-4.

Article  PubMed  CAS  Google Scholar 

Gao Y, Bado I, Wang H, Zhang W, Rosen JM, Zhang XHF. Metastasis Organotropism: redefining the congenial soil. Dev Cell. 2019;49:375–91. https://doi.org/10.1016/j.devcel.2019.04.012.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hajaj E, Sciacovelli M, Frezza C, Erez A. The context-specific roles of urea cycle enzymes in tumorigenesis. Mol Cell. 2021;81:3749–59.

Article  PubMed  CAS  Google Scholar 

Keshet R, Szlosarek P, Carracedo A, Erez A. Rewiring urea cycle metabolism in cancer to support anabolism. Nat Rev Cancer. 2018;18:634–45.

Article  PubMed  CAS  Google Scholar 

Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, et al. Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal 2014, 7. https://doi.org/10.1126/scisignal.2004761.

Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, et al. Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015;527:379–83. https://doi.org/10.1038/nature15529.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ji S. Overexpression of SLC25A15 is involved in the proliferation of cutaneous melanoma and leads to poor prognosis. Medecine/Sci. 2018;34:74–80. https://doi.org/10.1051/medsci/201834f113.

Article  Google Scholar 

Zou Z, Hu X, Luo T, Ming Z, Chen X, Xia L, et al. Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor. Nat Commun. 2021;12:2263. https://doi.org/10.1038/s41467-021-22235-8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang T, Hu L, Tang JF, Xu H, Tian K, Wu MN, et al. Metformin inhibits the urea cycle and reduces putrescine generation in colorectal cancer cell lines. Molecules. 2021;26:1990. https://doi.org/10.3390/molecules26071990.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Taya M, Merenbakh-Lamin K, Zubkov A, Honig Z, Kurolap A, Mayer O, et al. Beyond endocrine resistance: estrogen receptor (ESR1) activating mutations mediate chemotherapy resistance through the JNK/c-Jun MDR1 pathway in breast cancer. Breast Cancer Res Treat. 2024;209:431–49.

Article  PubMed  PubMed Central  Google Scholar 

Schmidt EK, Clavarino G, Ceppi M, Pierre P. SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods. 2009;6:275–7. https://doi.org/10.1038/nmeth.1314.

Article  PubMed  CAS  Google Scholar 

Feldman B, Fedida-Metula S, Nita J, Sekler I, Fishman D. Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells. Cell Calcium. 2010;47:525–37. https://doi.org/10.1016/j.ceca.2010.05.002.

Article  PubMed  CAS  Google Scholar 

Jeselsohn R, Yelensky R, Buchwalter G, Frampton G, Meric-Bernstam F, Gonzalez-Angulo AM, et al. Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res. 2014;20:1757–67. https://doi.org/10.1158/1078-0432.CCR-13-2332.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wei Q, Qian Y, Yu J, Wong CC. Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications. Oncogene. 2020;39:6139–56. https://doi.org/10.1038/s41388-020-01432-7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Häussinger D, Sies H, Gerok W. Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J Hepatol. 1985;1:3–14. https://doi.org/10.1016/S0168-8278(85)80063-5.

Article  PubMed  Google Scholar 

Martí i Líndez AA, Reith W. Arginine-dependent immune responses. Cell Mol Life Sci. 2021;78:5303–24. https://doi.org/10.1007/s00018-021-03828-4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Toy W, Weir H, Razavi P, Lawson M, Goeppert AU, Mazzola AM, et al. Activating ESR1 mutations differentially affect the efficacy of ER antagonists. Cancer Discov. 2017;7:277–87. https://doi.org/10.1158/2159-8290.CD-15-1523.

Article  PubMed  CAS  Google Scholar 

Corné J, Quillien V, Callens C, Portois P, Bidard FC, Jeannot E, et al. Development of sensitive and robust multiplex digital PCR assays for the detection of ESR1 mutations in the plasma of metastatic breast cancer patients. Clin Chim Acta. 2023;545:117366. https://doi.org/10.1016/j.cca.2023.117366.

Article  PubMed  CAS  Google Scholar 

Decotret LR, Shi R, Thomas KN, Hsu M, Pallen CJ, Bennewith KL. Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment. Front Oncol 2023;13. https://doi.org/10.3389/fonc.2023.976945.

Neve A, Santhana Kumar K, Tripolitsioti D, Grotzer MA, Baumgartner M. Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model. Sci Rep. 2017;7. 5297. https://doi.org/10.1038/s41598-017-05573-w.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eisemann T, Costa B, Strelau J, Mittelbronn M, Angel P, Peterziel H. An advanced glioma cell invasion assay based on organotypic brain slice cultures. BMC Cancer. 2018;18:103. https://doi.org/10.1186/s12885-018-4007-4.

Article  PubMed  PubMed Central