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Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Bidirectional signaling between the brain and peripheral tumors plays a major part in cancer biology but is poorly underst...
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
Tumor protein p53 (TP53) is the most frequently mutated gene across many cancers and is associated with shorter overall su...
Author Correction: Evolving landscape of nasopharyngeal carcinoma therapy
Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, ChinaKar Wei Chi...
Primary tumor chromatin landscape governs metastatic organotropism
Primary tumor chromatin landscape governs metastatic organotropism
Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether su...
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Chimeric antigen receptor (CAR) T cells can mediate durable complete responses in individuals with certain hematologic mal...
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis
Cancers often originate from precursor cells within an inflamed microenvironment; however, the mechanisms by which these p...
SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation
SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation
Systemic therapy is the optimal choice for individuals with unresectable or advanced hepatocellular carcinoma (HCC). Howev...
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial
Treatment options for advanced or metastatic intrahepatic cholangiocarcinoma (ICC) are limited. In this single-arm, phase ...
Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics
Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics
Bacteria-based therapies hold great promise for cancer treatment due to their selective tumor colonization and proliferati...
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway
The spleen plays a critical role in the pathogenesis of leukemia. However, our understanding of the splenic niche is very ...
Targeting anti-androgen therapy resistance through epigenetic rewiring
Targeting anti-androgen therapy resistance through epigenetic rewiring
Although resistance develops in response to androgen receptor-targeted therapy in advanced prostate cancer, the underlying...
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
The transdifferentiation from adenocarcinoma to neuroendocrine prostate cancer (NEPC) in men confers antiandrogen therapy ...
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity
Ferroptosis is closely linked with various pathophysiological processes, including aging, neurodegeneration, ischemia-repe...
Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
A major challenge in developing chimeric antigen receptor (CAR)-engineered cell therapies for acute myeloid leukemia (AML)...
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
Acute myeloid leukemia (AML)-specific target antigens are difficult to identify. Here we demonstrate that HLA-DRB1 can ser...
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
Cutaneous melanomas express a high number of potential neoepitopes, yet a substantial fraction of melanomas shift into imm...
First, novel and paradigm-shifting
First, novel and paradigm-shifting
In delineating scientific findings, authors should avoid assertions of primacy and novelty, in favor of measured descripti...
A deep dive into transmissible cancer evolution in bivalve mollusks
A deep dive into transmissible cancer evolution in bivalve mollusks
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and ...
Myeloma evades T cell-engaging therapies
Myeloma evades T cell-engaging therapies
Chimeric antigen receptor T cells and T cell-redirecting bispecific antibody therapies are changing the landscape of myelo...
Endothelium directs fat remodeling in cachexia
Endothelium directs fat remodeling in cachexia
Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cach...
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function...
Turning a failing PhD around
Turning a failing PhD around
Charles Swanton obtained a PhD from the Imperial Cancer Research Fund Laboratories (now the Francis Crick Institute) in 19...
Targeting network circuitry in glioma
Targeting network circuitry in glioma
The nervous system regulates cancer progression, and the importance of neuron–glioma communication in tumor growth i...
The never-abating excitement for targeted therapies
In combining technical innovation with foundational research, targeted therapies remain at the forefront of oncology drug ...
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-i...
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface ma...
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens
Despite improving outcomes, 40% of patients with newly diagnosed multiple myeloma treated with regimens containing daratum...
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia
Despite recent advances in the treatment of acute myeloid leukemia (AML), there has been limited success in targeting surf...
An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma
An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma
In vitro-transcribed (IVT) mRNA has arisen as a rapid method for the production of nucleic acid drugs. Here, we have const...
Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
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