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First-line durvalumab in combination with trastuzumab deruxtecan in women with locally advanced unresectable or metastatic, hormone-receptor-negative, HER2-low breast cancer: multicenter, open-label, phase 1b/2 BEGONIA platform trial
First-line durvalumab in combination with trastuzumab deruxtecan in women with locally advanced unresectable or metastatic, hormone-receptor-negative, HER2-low breast cancer: multicenter, open-label, phase 1b/2 BEGONIA platform trial
More effective therapies are required for advanced breast cancer. We report results from 58 women with locally advanced un...
Combination of paricalcitol with chemotherapy shows promise in phase 1 study of metastatic pancreatic cancer
Combination of paricalcitol with chemotherapy shows promise in phase 1 study of metastatic pancreatic cancer
We conducted a prospective, phase 1 trial evaluating the safety and tolerability of the vitamin D receptor agonist parical...
Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes
Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes
Molecular testing is essential for classifying central nervous system (CNS) tumors, with methylation profiling providing t...
Iron-mediated ferroptosis impairs CAR-T cell function and antitumor efficacy
Iron-mediated ferroptosis impairs CAR-T cell function and antitumor efficacy
Long-term persistence of chimeric antigen receptor (CAR)-T cells is essential for durable therapeutic efficacy but the mec...
Publisher Correction: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma
Julian BryanPresent address: Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The Universi...
Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets
Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets
Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematological malignancy. Here, to better d...
Mesenchymal tumor features predict response to immune-checkpoint blockade in glioblastoma
Mesenchymal tumor features predict response to immune-checkpoint blockade in glioblastoma
Multi-omics profiling of over 180 glioblastomas treated with immune-checkpoint blockade (ICB) revealed that the mesenchyma...
Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity
Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity
Disordered cholesterol–oxysterol profiles are observed in the tumor microenvironment, yet their roles in tumor-assoc...
Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Bidirectional signaling between the brain and peripheral tumors plays a major part in cancer biology but is poorly underst...
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
Tumor protein p53 (TP53) is the most frequently mutated gene across many cancers and is associated with shorter overall su...
Author Correction: Evolving landscape of nasopharyngeal carcinoma therapy
Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, ChinaKar Wei Chi...
Primary tumor chromatin landscape governs metastatic organotropism
Primary tumor chromatin landscape governs metastatic organotropism
Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether su...
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Chimeric antigen receptor (CAR) T cells can mediate durable complete responses in individuals with certain hematologic mal...
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis
Cancers often originate from precursor cells within an inflamed microenvironment; however, the mechanisms by which these p...
SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation
SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation
Systemic therapy is the optimal choice for individuals with unresectable or advanced hepatocellular carcinoma (HCC). Howev...
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial
Treatment options for advanced or metastatic intrahepatic cholangiocarcinoma (ICC) are limited. In this single-arm, phase ...
Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics
Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics
Bacteria-based therapies hold great promise for cancer treatment due to their selective tumor colonization and proliferati...
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway
The spleen plays a critical role in the pathogenesis of leukemia. However, our understanding of the splenic niche is very ...
Targeting anti-androgen therapy resistance through epigenetic rewiring
Targeting anti-androgen therapy resistance through epigenetic rewiring
Although resistance develops in response to androgen receptor-targeted therapy in advanced prostate cancer, the underlying...
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
The transdifferentiation from adenocarcinoma to neuroendocrine prostate cancer (NEPC) in men confers antiandrogen therapy ...
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity
Ferroptosis is closely linked with various pathophysiological processes, including aging, neurodegeneration, ischemia-repe...
Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
A major challenge in developing chimeric antigen receptor (CAR)-engineered cell therapies for acute myeloid leukemia (AML)...
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
Acute myeloid leukemia (AML)-specific target antigens are difficult to identify. Here we demonstrate that HLA-DRB1 can ser...
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
Cutaneous melanomas express a high number of potential neoepitopes, yet a substantial fraction of melanomas shift into imm...
First, novel and paradigm-shifting
First, novel and paradigm-shifting
In delineating scientific findings, authors should avoid assertions of primacy and novelty, in favor of measured descripti...
A deep dive into transmissible cancer evolution in bivalve mollusks
A deep dive into transmissible cancer evolution in bivalve mollusks
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and ...
Myeloma evades T cell-engaging therapies
Myeloma evades T cell-engaging therapies
Chimeric antigen receptor T cells and T cell-redirecting bispecific antibody therapies are changing the landscape of myelo...
Endothelium directs fat remodeling in cachexia
Endothelium directs fat remodeling in cachexia
Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cach...
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function...
Turning a failing PhD around
Turning a failing PhD around
Charles Swanton obtained a PhD from the Imperial Cancer Research Fund Laboratories (now the Francis Crick Institute) in 19...
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