Travis, W. D. et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J. Thorac. Oncol. 10, 1243–1260 (2015).
The Cancer Genome Atlas Research. Network Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519–525 (2012).
The Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543–550 (2014).
Hanna, N. H. et al. Therapy for stage IV non-small-cell lung cancer with driver alterations: ASCO and OH (CCO) joint guideline update. J. Clin. Oncol. 39, 1040–1091 (2021).
Article CAS PubMed Google Scholar
Howlader, N. et al. The effect of advances in lung-cancer treatment on population mortality. N. Engl. J. Med. 383, 640–649 (2020).
Article CAS PubMed PubMed Central Google Scholar
Herbst, R. S., Morgensztern, D. & Boshoff, C. The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2018).
Article CAS PubMed Google Scholar
Forde, P. M. et al. Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N. Engl. J. Med. 386, 1973–1985 (2022).
Article CAS PubMed PubMed Central Google Scholar
Non-small cell lung cancer treatment. National Cancer Institute https://www.cancer.gov/types/lung/patient/non-small-cell-lung-treatment-pdq (2021).
Campbell, J. D. et al. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat. Genet. 48, 607–616 (2016).
Article CAS PubMed PubMed Central Google Scholar
Halvorsen, A. R. et al. TP53 mutation spectrum in smokers and never smoking lung cancer patients. Front. Genet. 7, 85 (2016).
Article PubMed PubMed Central Google Scholar
Kaubryte, J. & Lai, A. G. Pan-cancer prognostic genetic mutations and clinicopathological factors associated with survival outcomes: a systematic review. npj Precis. Oncol. 6, 27 (2022).
Al Bakir, M. et al. The evolution of non-small cell lung cancer metastases in TRACERx. Nature 616, 534–542 (2023).
Article CAS PubMed PubMed Central Google Scholar
Van Egeren, D. et al. Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis. Sci. Rep. 12, 19055 (2022).
Article PubMed PubMed Central Google Scholar
Duffy, M. J., Synnott, N. C., O’Grady, S. & Crown, J. Targeting p53 for the treatment of cancer. Semin. Cancer Biol. 79, 58–67 (2022).
Article CAS PubMed Google Scholar
Bykov, V. J. N., Eriksson, S. E., Bianchi, J. & Wiman, K. G. Targeting mutant p53 for efficient cancer therapy. Nat. Rev. Cancer 18, 89–102 (2018).
Article CAS PubMed Google Scholar
Zhu, G. et al. Mutant p53 in cancer progression and targeted therapies. Front. Oncol. 10, 595187 (2020).
Article PubMed PubMed Central Google Scholar
Uehara, I. & Tanaka, N. Role of p53 in the regulation of the inflammatory tumor microenvironment and tumor suppression. Cancers 10, 219 (2018).
Article PubMed PubMed Central Google Scholar
Shi, D. & Jiang, P. A different facet of p53 function: regulation of immunity and inflammation during tumor development. Front. Cell Dev. Biol. 9, 762651 (2021).
Article PubMed PubMed Central Google Scholar
Hodis, E. et al. Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment. Science 376, eabi8175 (2022).
Article CAS PubMed PubMed Central Google Scholar
Efe, G., Rustgi, A. K. & Prives, C. p53 at the crossroads of tumor immunity. Nat. Cancer 5, 983–995 (2024).
Skoulidis, F. et al. STK11/LKB1 mutations and PD-1 inhibitor resistance in KRAS-mutant lung adenocarcinoma. Cancer Discov. 8, 822–835 (2018).
Article CAS PubMed PubMed Central Google Scholar
Biton, J. et al. TP53, STK11, and EGFR mutations predict tumor immune profile and the response to anti-PD-1 in lung adenocarcinoma. Clin. Cancer Res. 24, 5710–5723 (2018).
Article CAS PubMed Google Scholar
Dong, Z. Y. et al. Potential predictive value of TP53 and KRAS mutation status for response to PD-1 blockade immunotherapy in lung adenocarcinoma. Clin. Cancer Res. 23, 3012–3024 (2017).
Article CAS PubMed Google Scholar
Leader, A. M. et al. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell 39, 1594–1609 (2021).
Article CAS PubMed PubMed Central Google Scholar
Davis, A. P. et al. Efficacy of immunotherapy in KRAS-mutant non-small-cell lung cancer with comutations. Immunotherapy 13, 941–952 (2021).
Article CAS PubMed Google Scholar
Scalera, S. et al. KEAP1 and TP53 frame genomic, evolutionary, and immunologic subtypes of lung adenocarcinoma with different sensitivity to immunotherapy. J. Thorac. Oncol. 16, 2065–2077 (2021).
Article CAS PubMed Google Scholar
Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888–1902 (2019).
Article CAS PubMed PubMed Central Google Scholar
Dudley, A. C. Tumor endothelial cells. Cold Spring Harb. Perspect. Med. 2, a006536 (2012).
Article PubMed PubMed Central Google Scholar
Cooke, V. G. et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by Met signaling pathway. Cancer Cell 21, 66–81 (2012).
Article CAS PubMed PubMed Central Google Scholar
De Zuani, M. et al. Single-cell and spatial transcriptomics analysis of non-small cell lung cancer. Nat. Commun. 15, 4388 (2024).
Article PubMed PubMed Central Google Scholar
Takano, Y. et al. Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development. Nat. Commun. 15, 10637 (2024).
Article CAS PubMed PubMed Central Google Scholar
Greenwald, A. C. et al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma. Cell 187, 2485–2501 (2024).
Article CAS PubMed PubMed Central Google Scholar
Li, R. et al. Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer. Cancer Cell 40, 1583–1599 (2022).
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