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This is a summary of: Perez, K. J. et al. Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial. Nat. Cancer https://doi.org/10.1038/s43018-026-01165-8 (2026).