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Artificial intelligence-driven pathomics in hepatocellular carcinoma: current developments, challenges and perspectives
Artificial intelligence-driven pathomics in hepatocellular carcinoma: current developments, challenges and perspectives
Hepatocellular carcinoma (HCC) is a highly malignant tumor with elevated incidence and mortality rates globally. Its compl...
Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization
Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization
Lung cancer remains the leading cause of cancer-related mortality globally. Despite advancements in treatment, survival ra...
Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials
Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials
Neoadjuvant stereotactic radiotherapy (NaSRT) represents a promising approach in managing brain metastases, potentially of...
CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma
CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma
The tumor microenvironment (TME) of kidney renal clear cell carcinoma (KIRC) exhibits complex dynamics among immune, strom...
A web-based prediction model for brain metastasis in non-small cell lung cancer patients
A web-based prediction model for brain metastasis in non-small cell lung cancer patients
Brain metastasis (BM) stands as a significant contributor to mortality among cancer patients. The factors contributing to ...
Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization
Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization
This study presents a comprehensive investigation into the molecular mechanisms of hepatocellular carcinoma (HCC) through ...
Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma
Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma
As a co-receptor for vascular endothelial growth factor, neuropilin receptor type-1 (NRP-1) plays a crucial role in tumor ...
Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis (2005–2024)
Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis (2005–2024)
The androgen receptor (AR) remains a focal target in castration-resistant prostate cancer (CRPC) research, with recent stu...
Alterations in GSH/GSSG and CyS/CySS redox status in small cell lung cancer patients undergoing chemotherapy
Alterations in GSH/GSSG and CyS/CySS redox status in small cell lung cancer patients undergoing chemotherapy
In small cell lung cancer (SCLC), oxidative stress disrupts redox balance and contributes to tumor progression and treatme...
Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers
Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers
Liver cancer may be related to changes in brain structure, but clear causal evidence is lacking. This study aims to invest...
The complex role and molecular mechanism of family with sequence similarity genes in cancer: a comprehensive review
The complex role and molecular mechanism of family with sequence similarity genes in cancer: a comprehensive review
The family with sequence similarity (FAM) is a family of genes with unknown functions and similar sequences. However, rece...
Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis
Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis
The role of gut microbiota in tumorigenesis has gained significant attention in recent years. This study aimed to investig...
Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing
Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing
Cholesterol metabolism plays a significant role in cancer progression, including prostate adenocarcinoma (PRAD), making it...
Bibliometric insights into molecular and bioinformatic research trends on ameloblastoma
Bibliometric insights into molecular and bioinformatic research trends on ameloblastoma
The study aimed to evaluate the significant trends of advancement in the body of literature of specialty journals on molec...
TSC2-mutated perivascular epithelioid cell tumor with partial response to mTOR inhibition: a case report and literature review
TSC2-mutated perivascular epithelioid cell tumor with partial response to mTOR inhibition: a case report and literature review
Perivascular epithelioid cell tumors (PEComas), rare mesenchymal neoplasms with heterogeneous behavior, are molecularly ch...
Construction of an immune prediction model for osteosarcoma based on coagulation-related genes
Construction of an immune prediction model for osteosarcoma based on coagulation-related genes
The prognostic outcome of osteosarcoma, as the most common primary malignancy in children and adolescents, has not improve...
Analysis of 5 cases of PICC removal difficulty caused by fibroblastic sleeve
Analysis of 5 cases of PICC removal difficulty caused by fibroblastic sleeve
To explore the difficulties and solutions encountered during the removal of PICC catheters in five patients with a fibrobl...
Two-sample Mendelian randomization analysis of the causal association between circulating inflammatory proteins and osteosarcoma
Two-sample Mendelian randomization analysis of the causal association between circulating inflammatory proteins and osteosarcoma
To investigate the causal relationship between 91 circulating inflammatory proteins and osteosarcoma using the two-sample ...
Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway
Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway
The complicated radioresistance remains an intractable cause of treatment failure in glioblastoma (GBM). The cytoskeletal ...
Prognostic value of FDG PET/CT in special types of breast cancer with non-favorable histology
Prognostic value of FDG PET/CT in special types of breast cancer with non-favorable histology
Prognostic factors for special types of breast cancer remain poorly understood owing to limited clinical research. Therefo...
Resection margins, lymph node harvest and 3 year survival in open and laparoscopic colorectal cancer surgery; a prospective cohort study
Resection margins, lymph node harvest and 3 year survival in open and laparoscopic colorectal cancer surgery; a prospective cohort study
Laparoscopic colorectal cancer surgery has been gaining popularity in the last decade. However, there are concerns about a...
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
Breast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective...
β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
To investigate the influence of β-arrestin2 on the docetaxel resistance in castration-resistant prostate cancer (CRPC...
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
The overexpression of ALOX5AP has been observed in many types of cancer and has been identified as an oncogene. However, i...
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
Gastric cancer (GC) is a heterogeneous malignancy with variable clinical outcomes. The immune system has been implicated i...
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
Small GTPases regulate multiple important cellular behaviors and their activities are strictly controlled by a mass of reg...
A comprehensive analysis of SLC25A1 expression and its oncogenic role in pan-cancer
A comprehensive analysis of SLC25A1 expression and its oncogenic role in pan-cancer
The solute carrier family 25 member 1 (SLC25A1) is currently the only known human transporter for citrat...
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
To improve early diagnosis and chemotherapy efficacy monitoring in primary central nervous system lymphoma (PCNSL), cerebr...
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
Lipid metabolism is a key factor in tumorigenesis and drug resistance, and models related to lipid metabolism have shown p...
Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma
Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma
ATP-binding cassette A1 (ABCA1) is a potential prognostic marker for various tumor types. However, the biological effects ...
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