Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49. https://doi.org/10.3322/caac.21820.
Tan K, Naylor M. The influence of modifiable factors on breast and prostate cancer risk and disease progression. Front Physiol. 2022. https://doi.org/10.3389/fphys.2022.840826.
Article PubMed PubMed Central Google Scholar
Quinn TJ, Chapman D, Parzen J, Wahl DR, McNamara A, Dess R, Chan J, Feng F, Jackson WC, Hamstra D. Validation of the combination gleason score as an independent favorable prognostic factor in prostate cancer treated with dose-escalated radiation therapy. Pract Radiat Oncol. 2023;13(2):e166–75. https://doi.org/10.1016/j.prro.2022.08.013.
Hamdy F, Donovan J, Lane J, Mason M, Metcalfe C, Holding P, Davis M, Peters T, Turner E, Martin R, Oxley J, Robinson M, Staffurth J, Walsh E, Bollina P, Catto J, Doble A, Doherty A, Gillatt D, Kockelbergh R, Kynaston H, Paul A, Powell P, Prescott S, Rosario D, Rowe E, Neal D, Neal D. 10-Year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med. 2017;375(15):1415–24. https://doi.org/10.1056/NEJMoa1606220.
Feng D, Zhu W, You J, Shi X, Han P, Wei W, Wei Q, Yang L. Mitochondrial aldehyde dehydrogenase 2 represents a potential biomarker of biochemical recurrence in prostate cancer patients. Molecules. 2022;27(18):6000. https://doi.org/10.3390/molecules27186000.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Fan J, Chen T, Xu L, Liu P, Xiao L, Wu T, Zhou Q, Zheng Q, Liu C, Chan FL, Wu D. A novel ferroptosis-related gene prognostic index for prognosis and response to immunotherapy in patients with prostate cancer. Front Endocrinol. 2022;13:975623. https://doi.org/10.3389/fendo.2022.975623.
Huang B, Song B, Xu C. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nat Metab. 2020;2:132–41. https://doi.org/10.1038/s42255-020-0174-0.
Boele S, Siltari A, Raittinen P, Schleutker J, Taari K, Talala K, Tammela T, Auvinen A, Murtola T. Abstract 6486: Single nucleotide polymorphisms that predict serum cholesterol as a prostate cancer prognostic factor—a Mendelian randomization study. Can Res. 2023. https://doi.org/10.1158/1538-7445.am2023-6486.
Škara L, Huđek Turković A, Pezelj I, Vrtarić A, Sinčić N, Krušlin B, Ulamec M. Prostate cancer-focus on cholesterol. Cancers. 2021;13(18):4696. https://doi.org/10.3390/cancers13184696.
Article CAS PubMed PubMed Central Google Scholar
Siltari A, Syvälä H, Lou YR, Gao Y, Murtola TJ. Role of lipids and lipid metabolism in prostate cancer progression and the tumor’s immune environment. Cancers. 2022;14(17):4293. https://doi.org/10.3390/cancers14174293.
Article CAS PubMed PubMed Central Google Scholar
Dłubek J, Rysz J, Jabłonowski Z, Gluba-Brzózka A, Franczyk B. The correlation between lipid metabolism disorders and prostate cancer. Curr Med Chem. 2021;28(10):2048–61. https://doi.org/10.2174/0929867327666200806103744.
Article CAS PubMed Google Scholar
Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BW. Integrating mouse and human genetic data to move beyond GWAS and identify causal genes in cholesterol metabolism. Cell Metab. 2020;31(4):741-754.e5. https://doi.org/10.1016/j.cmet.2020.02.015.
Article CAS PubMed PubMed Central Google Scholar
Yang N, Yang Y, Huang Z, Chen H. Deregulation of cholesterol homeostasis by a nuclear hormone receptor crosstalk in advanced prostate cancer. Cancers. 2022. https://doi.org/10.3390/cancers14133110.
Article PubMed PubMed Central Google Scholar
Gordon JA, Noble JW, Midha A, Derakhshan F, Wang G, Adomat HH, Tomlinson Guns ES, Lin YY, Ren S, Collins CC, Nelson PS, Morrissey C, Wasan KM, Cox ME. Upregulation of scavenger receptor B1 is required for steroidogenic and nonsteroidogenic cholesterol metabolism in prostate cancer. Can Res. 2019;79(13):3320–31. https://doi.org/10.1158/0008-5472.CAN-18-2529.
Cheng Y, Meng Y, Li S, Cao D, Ben S, Qin C, Hua L, Cheng G. Genetic variants in the cholesterol biosynthesis pathway genes and risk of prostate cancer. Gene. 2021;774:145432. https://doi.org/10.1016/j.gene.2021.145432.
Article CAS PubMed Google Scholar
Thurtle DR, Jenkins V, Pharoah PD, Gnanapragasam VJ. Understanding of prognosis in non-metastatic prostate cancer: a randomised comparative study of clinician estimates measured against the PREDICT prostate prognostic model. Br J Cancer. 2019;121(8):715–8. https://doi.org/10.1038/s41416-019-0569-4.
Article PubMed PubMed Central Google Scholar
Meo N, Lasorsa F, Rutigliano M, Milella M, Ferro M, Battaglia M, Ditonno P, Lucarelli G. The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery. Expert Rev Mol Diagn. 2023;23:297–313. https://doi.org/10.1080/14737159.2023.2195553.
Article CAS PubMed Google Scholar
Huber F, Montani M, Sulser T, Jaggi R, Wild P, Moch H, Gevensleben H, Schmid M, Wyder S, Kristiansen G. Comprehensive validation of published immunohistochemical prognostic biomarkers of prostate cancer -what has gone wrong? A blueprint for the way forward in biomarker studies. Br J Cancer. 2015;112(1):140–8. https://doi.org/10.1038/bjc.2014.588.
Article CAS PubMed Google Scholar
Harlan SR, Cooperberg MR, Elkin E, Lubeck DP, Meng M, Mehta SS, Carroll PR. Time trends and characteristics of men choosing watchful waiting for initial treatment of localized prostate cancer: results from CaPSURE. J Urol. 2003;170(5):1804–7. https://doi.org/10.1097/01.ju.0000091641.34674.11.
Wang H, Liu Z, Wang Y, Han D, Du Y, Zhang B, He Y, Liu J, Xiong W, Zhang X, Gao Y, Shang P. Comprehensive analysis of fatty acid metabolism-related gene signatures for predicting prognosis in patients with prostate cancer. PeerJ. 2023. https://doi.org/10.7717/peerj.14646.
Article PubMed PubMed Central Google Scholar
Guo T, Wang J, Yan S, Meng X, Zhang X, Xu S, Ren S, Huang Y. A combined signature of glycolysis and immune landscape predicts prognosis and therapeutic response in prostate cancer. Front Endocrinol. 2022. https://doi.org/10.3389/fendo.2022.1037099.
Feng D, Shi X, Zhang F, Xiong Q, Wei Q, Yang L. Energy metabolism-related gene prognostic index predicts biochemical recurrence for patients with prostate cancer undergoing radical prostatectomy. Front Immunol. 2022. https://doi.org/10.3389/fimmu.2022.839362.
Article PubMed PubMed Central Google Scholar
Scheinberg T, Mak B, Butler L, Selth L, Horvath LG. Targeting lipid metabolism in metastatic prostate cancer. Ther Adv Med Oncol. 2023;15:17588359231152840. https://doi.org/10.1177/17588359231152839.
Article CAS PubMed PubMed Central Google Scholar
Eckhardt C, Sbiera I, Krebs M, Sbiera S, Spahn M, Kneitz B, Joniau S, Fassnacht M, Kübler H, Weigand I, Kroiss M. High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. Prostate Cancer Prostatic Dis. 2021;25:484–90. https://doi.org/10.1038/s41391-021-00431-3.
Article CAS PubMed PubMed Central Google Scholar
Tang L, Wei R, Chen R, Fan G, Zhou J, Qi Z, Wang K, Wei Q, Wei X, Xu X. Establishment and validation of a cholesterol metabolism-related prognostic signature for hepatocellular carcinoma. Comput Struct Biotechnol J. 2022;20:4402–14. https://doi.org/10.1016/j.csbj.2022.07.030.
Article CAS PubMed PubMed Central Google Scholar
Zhao N, Qu C, Yang Y, Li H, Li Y, Zhu H, Long Z. Identification of a cholesterol metabolism-related prognostic signature for multiple myeloma. Sci Rep. 2023;13(1):19395. https://doi.org/10.1038/s41598-023-46426-z.
Article CAS PubMed PubMed Central Google Scholar
Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Singaraja RR. ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels. Arterioscler Thromb Vasc Biol. 2017;37(11):2147–55. https://doi.org/10.1161/ATVBAHA.117.309574.
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