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Precision Medicine for the Treatment of Colorectal Cancer: the Evolution and Status of Molecular Profiling and Biomarkers
Precision Medicine for the Treatment of Colorectal Cancer: the Evolution and Status of Molecular Profiling and Biomarkers
The application of advanced genomic testing to develop tumor-specific molecular profiles is essential to facilitating prec...
What Rectal Cancer Patients May Be Able to Safely Avoid Radiation?
What Rectal Cancer Patients May Be Able to Safely Avoid Radiation?
Rectal cancers are treated with chemotherapy, radiotherapy, and surgery. While trials have illustrated the benefits of rad...
Emerging Role of Brachytherapy in the Non-operative Management of Rectal Cancer
Emerging Role of Brachytherapy in the Non-operative Management of Rectal Cancer
The non-operative management of rectal cancer is an area of active research. Dose-escalated radiotherapy may improve susta...
Toxicity Management in the Era of Changing Treatment Paradigms for Locally Advanced Rectal Cancer
Toxicity Management in the Era of Changing Treatment Paradigms for Locally Advanced Rectal Cancer
Treatment paradigms for locally advanced rectal cancer have evolved over the last several decades. Patients now have sever...
Local Therapies for Colorectal Cancer Oligometastases to the Lung
Local Therapies for Colorectal Cancer Oligometastases to the Lung
There is a growing consensus that oligometastatic disease-directed treatment is associated with improved oncologic outcome...
Surgical Management of Metastatic Colorectal Cancer
Surgical Management of Metastatic Colorectal Cancer
The surgical management of metastatic colorectal cancer (CRC) has evolved over time. Most often, the management of asympto...
Current Updates on HER2–Directed Therapies in Metastatic Colorectal Cancer
Current Updates on HER2–Directed Therapies in Metastatic Colorectal Cancer
Colorectal cancer is the third most common malignancy in the USA with 20% of patients presenting with metastatic disease. ...
Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy: A Meta-Analysis and Systematic Review
Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy: A Meta-Analysis and Systematic Review
Laparoscopic hemicolectomy (LHC) is widely used to treat benign and malignant colorectal disease. However, the optimal met...
Liver-Directed Therapy for Metastatic Colon Cancer: Update
Liver-Directed Therapy for Metastatic Colon Cancer: Update
To discuss the emerging technologies in the field of Interventional radiology (IR) for the management of metastatic colore...
Imaging Advances on CT and MRI in Colorectal Cancer
Imaging Advances on CT and MRI in Colorectal Cancer
Colorectal cancer (CRC) is the most common gastrointestinal neoplasm. Imaging plays a key role in the primary diagnosis, r...
Current Options in the Management of Colorectal Cancer in Developing Countries: Central America Experience
Current Options in the Management of Colorectal Cancer in Developing Countries: Central America Experience
Evaluate the current options in the management of colorectal cancer (CRC) in developing countries. We emphasize the experi...
Optimal Use of FOLFOXIRI Plus Bevacizumab as First-Line Systemic Treatment in Metastatic Colorectal Cancer
Optimal Use of FOLFOXIRI Plus Bevacizumab as First-Line Systemic Treatment in Metastatic Colorectal Cancer
Colorectal cancer is the second leading cause of cancer-related deaths in the USA with more than half of diagnosed patient...
Immunotherapy in Colorectal Cancer: Potential of Fecal Transplant and Microbiota-Augmented Clinical Trials
Immunotherapy in Colorectal Cancer: Potential of Fecal Transplant and Microbiota-Augmented Clinical Trials
This review summarizes the role of the microbiome in colorectal cancer (CRC) in the setting of immunotherapy and emphasize...
Leisure-Time Physical Activity Versus Sedentary Behaviour in Relation to Colorectal Adenoma and Cancer: Are these Two Distinct Risk Factors?
Leisure-Time Physical Activity Versus Sedentary Behaviour in Relation to Colorectal Adenoma and Cancer: Are these Two Distinct Risk Factors?
This literature review provides an up-to-date overview of the evidence relating to the associations of leisure-time physic...
On Hereditary Colorectal Cancer: What Is the Appropriate Surgical Technique?
On Hereditary Colorectal Cancer: What Is the Appropriate Surgical Technique?
Explore the pathogenesis, unique features, and various prophylactic as well as therapeutic surgical techniques used in the...
Molecular Pathogenesis and Classification of Colorectal Carcinoma
Molecular Pathogenesis and Classification of Colorectal Carcinoma
Molecular pathways in colorectal carcinogenesis involve several complex genetic and epigenetic modulations that cause norm...
Non-surgical “Watch and Wait” Approach to Rectal Cancer
Non-surgical “Watch and Wait” Approach to Rectal Cancer
The standard of care for locally advanced rectal cancer is preoperative chemoradiation (CRT) followed by total mesorectal ...
Treating Colorectal Cancer with Immunotherapy: Implications for Single Versus Combination Therapy
Treating Colorectal Cancer with Immunotherapy: Implications for Single Versus Combination Therapy
Colorectal cancer (CRC) is the second leading cause of cancer-associated deaths in the USA, with most metastatic cases sub...
Total Neoadjuvant Therapy for Rectal Cancer: Current Status and Future Directions
Total Neoadjuvant Therapy for Rectal Cancer: Current Status and Future Directions
The investigation of total neoadjuvant therapy has increased significantly in recent years, with a number of approaches be...
Current Status of Biologics in Perioperative Treatment for Resectable or Borderline Resectable Liver Metastases
Current Status of Biologics in Perioperative Treatment for Resectable or Borderline Resectable Liver Metastases
This review provides an overview of the current role of biologics, anti-vascular endothelial growth factor (VEGF) inhibito...
Review and Updates on Approaches to Neoadjuvant Chemotherapy in Rectal Cancer
Review and Updates on Approaches to Neoadjuvant Chemotherapy in Rectal Cancer
The currently established standard of care treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradioth...
Non-operative Management (NOM) of Rectal Cancer: Literature Review and Translation of Evidence into Practice
Non-operative Management (NOM) of Rectal Cancer: Literature Review and Translation of Evidence into Practice
Despite mounting interest in the non-operative management (NOM, also known as watchful waiting) of rectal adenocarcinoma, ...
Behavioral Risk Factors and Risk of Early-Onset Colorectal Cancer: Review of the Mechanistic and Observational Evidence
Behavioral Risk Factors and Risk of Early-Onset Colorectal Cancer: Review of the Mechanistic and Observational Evidence
The goal of this review is to summarize recent evidence linking behavioral risk factors to early-onset colorectal cancer (...
Current Colorectal Cancer Reports
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The Role of Ablative Radiotherapy to Liver Oligometastases from Colorectal Cancer
The Role of Ablative Radiotherapy to Liver Oligometastases from Colorectal Cancer
This review describes recent data supporting locoregional ablative radiation in the treatment of oligometastatic colorecta...
Recent Advances in Functional MRI to Predict Treatment Response for Locally Advanced Rectal Cancer
Recent Advances in Functional MRI to Predict Treatment Response for Locally Advanced Rectal Cancer
Early response prediction for locally advanced rectal cancer (LARC) provides an opportunity for response-tailored treatmen...
Current Trends in the Treatment of Locally Advanced Rectal Cancer: Where We Are and How We Got Here
Current Trends in the Treatment of Locally Advanced Rectal Cancer: Where We Are and How We Got Here
The trimodal treatment for LARC—surgery, radiotherapy, and chemotherapy—has been the standard of care for more...
Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer
Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer
The aim of this paper is to summarize the current treatment landscape in metastatic colorectal cancer, as well as those on...
Role of MR-guided Radiotherapy (MRgRT) in Colorectal Cancer
Role of MR-guided Radiotherapy (MRgRT) in Colorectal Cancer
The current standard treatment for locally advanced or metastatic colorectal cancer often includes radiotherapy delivered ...
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