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Efficacy and safety of endoscopic resection followed by chemoradiotherapy with S-1 plus cisplatin for esophageal cancer
Efficacy and safety of endoscopic resection followed by chemoradiotherapy with S-1 plus cisplatin for esophageal cancer
Chemoradiotherapy (CRT) with 5-fluorouracil plus cisplatin is commonly used as additional treatment after endoscopic resec...
Clinical indications and implications of metastasis-directed therapy and primary-site treatment in metastatic urothelial carcinoma
Clinical indications and implications of metastasis-directed therapy and primary-site treatment in metastatic urothelial carcinoma
Metastatic urothelial carcinoma (mUC) is traditionally managed with systemic therapy; however, long-term disease control r...
Immediate prediction and early intervention for post-hepatectomy liver failure: external validation of the modified Rem-ALPlat index
Immediate prediction and early intervention for post-hepatectomy liver failure: external validation of the modified Rem-ALPlat index
Posthepatectomy liver failure (PHLF) is a leading cause of mortality. We established a modified Rem-ALPlat index integrati...
Pharmacotherapy for older adults with cancer: a digest of the Japanese clinical practice guidelines (2nd edition)—general principles
Pharmacotherapy for older adults with cancer: a digest of the Japanese clinical practice guidelines (2nd edition)—general principles
The global population is aging rapidly, and the incidence of cancer in older adults is increasing accordingly. However, ol...
Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey
Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey
Gender equity, work-life balance, and career development have become important concerns in the medical profession. However...
Second recurrence after R0 resection of recurrent colorectal cancer: patterns and implications for surveillance
Second recurrence after R0 resection of recurrent colorectal cancer: patterns and implications for surveillance
Although repeat metastasectomy can improve survival in selected patients with colorectal cancer (CRC), the patterns and ti...
Post-CCRT pelvic lymph node size and pathological nodal involvement in cervical cancer
Post-CCRT pelvic lymph node size and pathological nodal involvement in cervical cancer
Lymph node metastasis is an important prognostic factor in cervical cancer, but assessment of nodal response after concurr...
Recommendations for generating real-world evidence with regulatory-grade relevance and reliability
Recommendations for generating real-world evidence with regulatory-grade relevance and reliability
Real-world data (RWD) and real-world evidence (RWE) are increasingly incorporated into regulatory decision-making to compl...
Clinical significance of WES-defined amplification in resectable colorectal cancer
Clinical significance of WES-defined amplification in resectable colorectal cancer
HER2 amplification is demonstrated to influence response to therapy and outcomes in metastatic colorectal cancer (mCRC), b...
Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender–age–physiology staging system
Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender–age–physiology staging system
Selecting the optimal surgical strategy for lung cancer patients with interstitial lung disease (ILD) remains difficult. T...
Stage-dependent differences of long-term outcomes between chemoradiotherapy and surgery for squamous cell carcinoma of the anal canal: a multicenter retrospective cohort study
Stage-dependent differences of long-term outcomes between chemoradiotherapy and surgery for squamous cell carcinoma of the anal canal: a multicenter retrospective cohort study
Efficacy comparisons between surgery and chemoradiotherapy (CRT) in the treatment of squamous cell carcinoma (SCC) of the ...
Clinical characteristics and treatment patterns of tenosynovial giant cell tumor in Japan: an analysis of the Japanese bone and soft tissue tumor registry
Clinical characteristics and treatment patterns of tenosynovial giant cell tumor in Japan: an analysis of the Japanese bone and soft tissue tumor registry
Tenosynovial giant cell tumors (TGCT) are rare proliferative disorders arising from the synovium of the joints, tendon she...
Clinical value of prostate-specific antigen halving time as a predictor of response to first-line systemic treatment for synchronous metastatic castration-sensitive prostate cancer
Clinical value of prostate-specific antigen halving time as a predictor of response to first-line systemic treatment for synchronous metastatic castration-sensitive prostate cancer
To address the challenge of early predicting systemic treatment response in metastatic castration-sensitive prostate cance...
Real-world safety and effectiveness of nivolumab in patients with cancer of unknown primary: results from a nationwide post-marketing surveillance in Japan
Real-world safety and effectiveness of nivolumab in patients with cancer of unknown primary: results from a nationwide post-marketing surveillance in Japan
Cancer of unknown primary (CUP) is associated with poor prognosis. In December 2021, nivolumab was approved in Japan for t...
Proteinuria as the cause of early dose modification in Japanese patients with metastatic colorectal cancer treated with fruquintinib: a multicenter real-world study
Proteinuria as the cause of early dose modification in Japanese patients with metastatic colorectal cancer treated with fruquintinib: a multicenter real-world study
Fruquintinib has demonstrated survival benefits in patients with previously treated metastatic colorectal cancer (mCRC) in...
Histological heterogeneity of SLFN11 expression and its association with response to carboplatin plus paclitaxel therapy in salivary gland cancer
Histological heterogeneity of SLFN11 expression and its association with response to carboplatin plus paclitaxel therapy in salivary gland cancer
Schlafen family member 11 (SLFN11) has emerged as a potential biomarker of sensitivity to DNA-damaging agents, including p...
Clinical outcomes of near-infrared photoimmunotherapy according to immune checkpoint inhibitor timing and treatment sequence: a multicenter retrospective study
Clinical outcomes of near-infrared photoimmunotherapy according to immune checkpoint inhibitor timing and treatment sequence: a multicenter retrospective study
Near-infrared photoimmunotherapy (NIR-PIT) is a novel local treatment for recurrent or metastatic head and neck cancer. Ho...
Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies
Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies
Endometrial cancer represents a major global health concern, with rising incidence particularly in developed countries des...
Microflora: a promising potential in the diagnosis and treatment of non-small cell lung cancer
Microflora: a promising potential in the diagnosis and treatment of non-small cell lung cancer
The incidence and mortality of non-small cell lung cancer (NSCLC) remain high in China. Recently, several studies have sho...
Real-world experience of circulating tumor DNA testing in resectable colorectal cancer: a Japanese single-institution observational study
Real-world experience of circulating tumor DNA testing in resectable colorectal cancer: a Japanese single-institution observational study
Assessment of molecular residual disease (MRD) using circulating tumor DNA (ctDNA) is a powerful prognostic tool for detec...
Prognostic and clinicopathological implications of mismatch-repair deficiency and promoter methylation status in endometrial carcinoma
Prognostic and clinicopathological implications of mismatch-repair deficiency and promoter methylation status in endometrial carcinoma
The prevalence of MSI-H and MLH1 promoter hypermethylation (MLH1-PHM) as well as Lynch syndrome in Japanese patients with ...
Radiotherapy with or without chemotherapy for T2N0 hypopharyngeal cancer: an analysis of the head and neck cancer registry of Japan
Radiotherapy with or without chemotherapy for T2N0 hypopharyngeal cancer: an analysis of the head and neck cancer registry of Japan
This retrospective study compared the outcomes of radiotherapy (RT) and chemoradiotherapy (CRT) in patients with T2N0 hypo...
Impact of baseline regular magnesium oxide administration on chemotherapy-induced constipation during cisplatin-containing treatment
Impact of baseline regular magnesium oxide administration on chemotherapy-induced constipation during cisplatin-containing treatment
Chemotherapy-induced constipation frequently occurs with cisplatin-containing treatments, partly because of concomitant ne...
Long-term progression-free survivors (“super responders”) to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s)
Long-term progression-free survivors (“super responders”) to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s)
PARP inhibitors have been shown to improve progression-free survival in patients with recurrent ovarian cancer. However, t...
The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis
The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis
Sepsis and septic shock are major causes of non-relapse mortality in cancer patients, with chemotherapy-induced neutropeni...
Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics)
Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics)
Anal canal carcinoma (ACC) is reported to be a rare cancer worldwide. In Japan, while the incidence rate is similarly low ...
Longitudinal assessment of health-related quality of life, sleep quality, and gustation in patients with advanced urothelial carcinoma receiving late-line enfortumab vedotin monotherapy
Longitudinal assessment of health-related quality of life, sleep quality, and gustation in patients with advanced urothelial carcinoma receiving late-line enfortumab vedotin monotherapy
To describe real-world data on health-related quality of life (HRQoL) in patients with locally advanced or metastatic urot...
Sequential changes in conditional survival of patients following surgical resection of colorectal cancer and indicators for follow-up beyond 5 years
Sequential changes in conditional survival of patients following surgical resection of colorectal cancer and indicators for follow-up beyond 5 years
The evolving prognosis of colorectal cancer (CRC) over extended periods following surgery has not been comprehensively cha...
Real-world effectiveness and safety of lisocabtagene maraleucel for relapsed/refractory large B cell lymphoma in Japan
Real-world effectiveness and safety of lisocabtagene maraleucel for relapsed/refractory large B cell lymphoma in Japan
Lisocabtagene maraleucel (liso-cel), an anti-CD19 CAR T cell therapy, has demonstrated efficacy in relapsed/refractory (R/...
Real-world safety and efficacy of immune checkpoint inhibitors in Japanese patients with persistent, recurrent, or metastatic cervical cancer: a multicenter prospective and retrospective study
Real-world safety and efficacy of immune checkpoint inhibitors in Japanese patients with persistent, recurrent, or metastatic cervical cancer: a multicenter prospective and retrospective study
To evaluate the real-world safety and efficacy of immune checkpoint inhibitors (ICIs) in Japanese patients with persistent...
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