Cancer Genome Atlas Research N, Kandoth C, Schultz N et al (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497(7447):67–73

Article  Google Scholar 

Talhouk A, McConechy MK, Leung S et al (2015) A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer 113(2):299–310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Concin N, Matias-Guiu X, Vergote I et al (2021) ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer 31(1):12–39

Article  PubMed  Google Scholar 

Talhouk A, McConechy MK, Leung S et al (2017) Confirmation of promise: a simple, genomics-based clinical classifier for endometrial cancer. Cancer 123(5):802–813

Article  CAS  PubMed  Google Scholar 

IARC (2020) WHO classification of tumors. Female genital tumours

Berek JS, Matias-Guiu X, Creutzberg C et al (2023) FIGO staging of endometrial cancer. J Gynecol Oncol 34(5):e85

Article  PubMed  PubMed Central  Google Scholar 

Hampel H, Frankel W, Panescu J et al (2006) Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res 66(15):7810–7817

Article  CAS  PubMed  Google Scholar 

Kahn RM, Gordhandas S, Maddy BP et al (2019) Universal endometrial cancer tumor typing: how much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population? Cancer 125(18):3172–3183

Article  CAS  PubMed  Google Scholar 

Leclerc J, Vermaut C, Buisine MP (2021) Diagnosis of Lynch syndrome and strategies to distinguish Lynch-related tumors from sporadic MSI/dMMR tumors. Cancers (Basel). https://doi.org/10.3390/cancers13030467

Article  PubMed  Google Scholar 

Post CCB, Stelloo E, Smit V et al (2021) Prevalence and prognosis of lynch syndrome and sporadic mismatch repair deficiency in endometrial cancer. J Natl Cancer Inst 113(9):1212–1220

Article  PubMed  PubMed Central  Google Scholar 

Cosgrove CM, Cohn DE, Hampel H et al (2017) Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival. Gynecol Oncol 146(3):588–595

Article  CAS  PubMed Central  Google Scholar 

Loukovaara M, Pasanen A, Butzow R (2021) Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer. Cancer Med 10(3):1034–1042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Kong JK, Yang W et al (2018) DNA mismatch repair protein immunohistochemistry and MLH1 promotor methylation testing for practical molecular classification and the prediction of prognosis in endometrial cancer. Cancers (Basel). https://doi.org/10.3390/cancers10090279

Article  PubMed  PubMed Central  Google Scholar 

Nagasaka T, Koi M, Kloor M et al (2008) Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 134(7):1950–1960

Article  CAS  PubMed  Google Scholar 

Japan Society of Obstetrics and Gynecology. Patient annual report for 2021 [Available from: https://fa.kyorin.co.jp/jsog/readPDF.php?file=75/12/075121643.pdf]

Kato MK, Fujii E, Asami Y et al (2024) Clinical features and impact of p53 status on sporadic mismatch repair deficiency and Lynch syndrome in uterine cancer. Cancer Sci 115(5):1646–1655

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takahashi K, Sato N, Sugawara T et al (2017) Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer. Gynecol Oncol 147(2):388–395

Article  PubMed  Google Scholar 

Yamamoto A, Yamaguchi T, Suzuki O et al (2021) Prevalence and molecular characteristics of DNA mismatch repair deficient endometrial cancer in a Japanese hospital-based population. Jpn J Clin Oncol 51(1):60–69

Article  PubMed  Google Scholar 

Akagi K, Oki E, Taniguchi H et al (2021) The real-world data on microsatellite instability status in various unresectable or metastatic solid tumors. Cancer Sci 2021:1

CAS  Google Scholar 

Latham A, Srinivasan P, Kemel Y et al (2019) Microsatellite instability is associated with the presence of Lynch syndrome pan-cancer. J Clin Oncol 37(4):286–295

Article  CAS  PubMed  Google Scholar 

Kaneko E, Sato N, Sugawara T et al (2021) MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas. J Gynecol Oncol 32(6):e79

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pasanen A, Loukovaara M, Butzow R (2020) Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma. Mod Pathol 33(7):1443–1452

Article  CAS  PubMed  Google Scholar 

Kato M, Takano M, Miyamoto M et al (2015) DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers. J Gynecol Oncol 26(1):40–45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Black D, Soslow RA, Levine DA et al (2006) Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma. J Clin Oncol 24(11):1745–1753

Article  CAS  PubMed  Google Scholar 

Leon-Castillo A, Britton H, McConechy MK et al (2020) Interpretation of somatic POLE mutations in endometrial carcinoma. J Pathol 250(3):323–335

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szatkowski W, Nowak-Jastrząb M, Kluz T et al (2025) Clinicopathological features and risk stratification of multiple-classifier endometrial cancers: a multicenter study from Poland. Cancers (Basel) 17(15):2483

Article  CAS  PubMed  Google Scholar 

Seeber L et al (2020) Mismatch repair deficiency and MLH1 promoter methylation in endometrial carcinoma: clinicopathological correlations and outcomes. Int J Gynecol Cancer 30(7):967–975

Google Scholar 

Capasso I, Cerami C, Vatrano S et al (2025) MLH1 promoter hypermethylation defines a distinct subset of mismatch repair–deficient endometrial carcinomas with aggressive features. Eur J Cancer 199:113–123

Google Scholar 

Zighelboim I, Goodfellow PJ, Gao F et al (2007) Microsatellite instability and MLH1 promoter methylation in endometrial carcinoma: clinical significance. Cancer 109(2):245–250

Google Scholar 

Hom-Tedla G et al (2019) Prognostic impact of MLH1 promoter methylation in endometrial cancer: a population-based study. Gynecol Oncol 153(2):310–316

Google Scholar 

Sloan EA, Ring KL, Willis BC et al (2017) PD-L1 expression in mismatch repair-deficient endometrial carcinomas, including Lynch syndrome-associated and MLH1 promoter hypermethylated tumors. Am J Surg Pathol 41(3):326–333

Article  PubMed  Google Scholar