Immediate prediction and early intervention for post-hepatectomy liver failure: external validation of the modified Rem-ALPlat index

Farmer DG, Rosove MH, Shaked A, Busuttil RW (1994) Current treatment modalities for hepatocellular carcinoma. Ann Surg 219:236–247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP et al (2012) Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut 61:1657–1669

Article  CAS  PubMed  Google Scholar 

de Jong MC, Pulitano C, Ribero D, Strub J, Mentha G, Schulick RD et al (2009) Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 250:440–448

Article  PubMed  Google Scholar 

Yoshino K, Yoh T, Taura K, Seo S, Ciria R, Briceño-Delgado J (2021) A systematic review of prediction models for post-hepatectomy liver failure in patients undergoing liver surgery. HPB (Oxford) 23(9):1311–1320

Article  PubMed  Google Scholar 

Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R et al (2011) Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery 149(5):713–724

Article  PubMed  Google Scholar 

Prodeau M, Drumez E, Duhamel A, Vibert E, Farges O, Lassailly G et al (2019) An ordinal model to predict the risk of symptomatic liver failure in patients with cirrhosis undergoing hepatectomy. J Hepatol 71(5):920–929

Article  PubMed  Google Scholar 

Ito H, Aldrighetti L, Ruzzenente A, Takahashi Y, Ferrero A, Katayama H (2019) The impact of posthepatectomy liver failure on long-term survival after resection for colorectal liver metastases. HPB (Oxford) 21(6):715–723

Google Scholar 

Nagino M, Kamiya J, Nishio H, Ebata T, Arai T, Nimura Y (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up. Ann Surg 243(3):364–372

Article  PubMed  PubMed Central  Google Scholar 

Rahbari NN, Reissfelder C, Koch M, Elbers H, Striebel F, Büchler MW et al (2011) The predictive value of postoperative clinical risk scores for outcome after hepatic resection: a validation analysis in 807 patients. Ann Surg Oncol 18(13):3640–3649

Article  PubMed  Google Scholar 

Zhang ZQ, Yang B, Zou H, Xiong L, Miao XY, Wen Y et al (2019) ALBI/ST ratio versus FIB-4 and APRI as a predictor of posthepatectomy liver failure in hepatocellular carcinoma patients. Med (Baltim) 98(15):e15168

Article  Google Scholar 

Mai RY, Ye JZ, Long ZR, Lin H, Zhang H, Chen Y et al (2019) Preoperative aspartate aminotransferase-to-platelet-ratio index as a predictor of posthepatectomy liver failure for resectable hepatocellular carcinoma. Cancer Manag Res 11:1401–1414

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chin KM, Allen JC, Teo JY, Kam JH, Tan EK, Koh Y et al (2018) Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma. Ann Hepatobiliary Pancreat Surg 22(3):185–196

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto G, Taura K, Ikai I, Fujikawa T, Nishitai R, Kaihara S et al (2020) ALPlat criterion for the resection of hepatocellular carcinoma based on a predictive model of posthepatectomy liver failure. Surgery 167(3):410–416

Article  PubMed  Google Scholar 

Morino K, Seo S, Yoh T, Toda R, Yoshino K, Nishio T et al (2023) Impact of the Intermittent Pringle Maneuver for Predicting Post-hepatectomy Liver Failure: A Cohort Study of 597 Consecutive Patients. World J Surg 47(4):1058–1067

Article  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP et al (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies. Ann Intern Med 147(8):573–577

Article  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP et al (2025) The STROBE reporting checklist. In: Harwood J, Albury C, Beyer J de, Schlüssel M, Collins G, editors. The EQUATOR network reporting guideline platform. The UK EQUATOR Centre; Available from: https:/resources.equator-network.org/reporting-guidelines/strobe/strobe-checklist.docx

Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N et al (2016) Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today 46(6):668–685

Article  PubMed  Google Scholar 

Wrighton LJ, O’Bosky KR, Namm JP, Senthil M (2012) Postoperative management after hepatic resection. J Gastrointest Oncol 3(1):41–47

PubMed  PubMed Central  Google Scholar 

Ma X, Huang T, Chen X, Li Q, Liao M, Fu L et al (2025) Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics. Signal Transduct Target Ther 10:45

Google Scholar 

Fisette A, Metrakos P, Hassanain M, Chaudhury P, Barkun J, Tchervenkov J et al (2012) High-dose insulin therapy reduces postoperative liver dysfunction and complications in liver resection patients through reduced apoptosis and altered inflammation. J Clin Endocrinol Metab 97(1):217–226

Article  CAS  PubMed  Google Scholar 

Han S, Ko JS, Jin SM, Park HW, Kim JM, Joh JW et al (2014) Intraoperative hyperglycemia during liver resection: predictors and association with the extent of hepatocytes injury. PLoS ONE 9(10):e109120

Article  PubMed  PubMed Central  Google Scholar 

Hiroi K, Matsusaki T, Kaku R, Umeda Y, Yagi T, Morimatsu H (2019) Postoperative course of serum albumin levels and organ dysfunction after liver transplantation. Transpl Proc 51(8):2750–2754

Article  CAS  Google Scholar 

Yamazaki S, Takayama T, Kimura Y, Moriguchi M, Higaki T, Nakayama H et al (2011) Transfusion criteria for fresh frozen plasma in liver resection: a 3 + 3 cohort expansion study. Arch Surg 146(11):1293–1299

Article  CAS  PubMed  Google Scholar 

Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D et al (2005) The 50–50 criteria on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg 242(6):824–828

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Schriefer AE, Cliften PF, Dietzen D, Kulkarni S, Sing S et al (2016) Postponing the hypoglycemic response to partial hepatectomy delays mouse liver regeneration. Am J Pathol 186(3):587–599

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y et al (2009) p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology 50(1):207–215

Article  CAS  PubMed  PubMed Central  Google Scholar 

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