Morad, G., Helmink, B. A., Sharma, P. & Wargo, J. A. Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell 184, 5309–5337 (2021).
Article CAS PubMed PubMed Central Google Scholar
Topalian, S. L. et al. Neoadjuvant immune checkpoint blockade: a window of opportunity to advance cancer immunotherapy. Cancer Cell 41, 1551–1566 (2023).
Article CAS PubMed PubMed Central Google Scholar
Dagher, O. K. & Posey, A. D. Jr. Forks in the road for CAR T and CAR NK cell cancer therapies. Nat. Immunol. 24, 1994–2007 (2023).
Article CAS PubMed Google Scholar
Tay, C., Tanaka, A. & Sakaguchi, S. Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. Cancer Cell 41, 450–465 (2023).
Article CAS PubMed Google Scholar
Albelda, S. M. CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn. Nat. Rev. Clin. Oncol. 21, 47–66 (2024).
Singh, N. & Maus, M. V. Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy. Immunity 56, 2296–2310 (2023).
Article CAS PubMed Google Scholar
Nong, C., Guan, P., Li, L., Zhang, H. & Hu, H. Tumor immunotherapy: mechanisms and clinical applications. Med. Comm. Oncol. https://doi.org/10.1002/mog2.8 (2022).
Zou, W., Wolchok, J. D. & Chen, L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci. Transl. Med. 8, 328rv324 (2016).
Khalil, D. N., Smith, E. L., Brentjens, R. J. & Wolchok, J. D. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat. Rev. Clin. Oncol. 13, 273–290 (2016).
Article CAS PubMed PubMed Central Google Scholar
Reina-Campos, M. et al. Metabolic programs of T cell tissue residency empower tumour immunity. Nature 621, 179–187 (2023).
Article CAS PubMed PubMed Central Google Scholar
Barry, M. & Bleackley, R. C. Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2, 401–409 (2002).
Article CAS PubMed Google Scholar
Golstein, P. & Griffiths, G. M. An early history of T cell-mediated cytotoxicity. Nat. Rev. Immunol. 18, 527–535 (2018).
Article CAS PubMed Google Scholar
Wang, W. et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569, 270–274 (2019).
Article CAS PubMed PubMed Central Google Scholar
Liao, P. et al. CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell 40, 365–378.e366 (2022).
Article CAS PubMed PubMed Central Google Scholar
Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012).
Article CAS PubMed PubMed Central Google Scholar
Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331 (2014).
Article CAS PubMed PubMed Central Google Scholar
Bell, H. N., Stockwell, B. R. & Zou, W. Ironing out the role of ferroptosis in immunity. Immunity 57, 941–956 (2024).
Article CAS PubMed Google Scholar
Mao, C. et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 593, 586–590 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bersuker, K. et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575, 688–692 (2019).
Article CAS PubMed PubMed Central Google Scholar
Doll, S. et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, 693–698 (2019).
Article CAS PubMed Google Scholar
Lei, G., Zhuang, L. & Gan, B. Targeting ferroptosis as a vulnerability in cancer. Nat. Rev. Cancer 22, 381–396 (2022).
Article CAS PubMed PubMed Central Google Scholar
Stockwell, B. R. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401–2421 (2022).
Article CAS PubMed PubMed Central Google Scholar
Xia, Y. et al. The mevalonate pathway is a druggable target for vaccine adjuvant discovery. Cell 175, 1059–1073.e1021 (2018).
Article CAS PubMed Google Scholar
Kim, S. et al. Blocking myristoylation of Src Inhibits its kinase activity and suppresses prostate cancer progression. Cancer Res. 77, 6950–6962 (2017).
Article CAS PubMed PubMed Central Google Scholar
Lao, Y. et al. Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma. J. Hepatol. https://doi.org/10.1016/j.jhep.2024.05.034 (2024).
Chen, B., Sun, Y., Niu, J., Jarugumilli, G. K. & Wu, X. Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities. Cell Chem. Biol. 25, 817–831 (2018).
Article CAS PubMed PubMed Central Google Scholar
Chen, S. et al. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature 549, 399–403 (2017).
Article CAS PubMed PubMed Central Google Scholar
Ko, P. J. & Dixon, S. J. Protein palmitoylation and cancer. EMBO Rep. 19, e46666. (2018).
Article PubMed PubMed Central Google Scholar
Qu, M., Zhou, X., Wang, X. & Li, H. Lipid-induced S-palmitoylation as a vital regulator of cell signaling and disease development. Int. J. Biol. Sci. 17, 4223–4237 (2021).
Article CAS PubMed PubMed Central Google Scholar
Jin, J., Zhi, X., Wang, X. & Meng, D. Protein palmitoylation and its pathophysiological relevance. J. Cell. Physiol. 236, 3220–3233 (2021).
Article CAS PubMed Google Scholar
Jiang, Y. et al. STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice. Sci. Signal. 16, eadd2282 (2023).
Article CAS PubMed PubMed Central Google Scholar
Mukai, K. et al. Activation of STING requires palmitoylation at the Golgi. Nat. Commun. 7, 11932 (2016).
Comments (0)