Nicholson JL, Leighton GR. Plastics come of age. Harper’s Mag. 1942;185:300–7.

Google Scholar 

Yang W, Jannatun N, Zeng Y, Liu T, Zhang G, Chen C, Li Y. Impacts of microplastics on immunity. Front Toxicol. 2022;4:956885.

Article  PubMed  PubMed Central  Google Scholar 

Zuri G, Karanasiou A, Lacorte S, Microplastics. Human exposure assessment through air, water, and food. Environ Int. 2023;179:108150. https://doi.org/10.1016/j.envint.2023.108150.

Article  CAS  PubMed  Google Scholar 

Sridharan S, Kumar M, Singh L, Bolan NS, Saha M. Microplastics as an emerging source of particulate air pollution: A critical review. J Hazard Mater. 2021;418:126245. https://doi.org/10.1016/j.jhazmat.2021.126245.

Article  CAS  PubMed  Google Scholar 

Bhatt V, Chauhan JS. Microplastic in freshwater ecosystem: bioaccumulation, trophic transfer, and biomagnification. Environ Sci Pollut Res Int. 2023;30(4):9389–400. https://doi.org/10.1007/s11356-022-24529-w.

Article  CAS  PubMed  Google Scholar 

Jambeck JR, Geyer R, Wilcox C, Siegler TR, Perryman M, Andrady A, et al. Marine pollution. Plastic waste inputs from land into the ocean. Science. 2015;347:768–71.

Article  CAS  PubMed  Google Scholar 

Lopes C, Ambrosino AC, Figueiredo C, Caetano M, Santos MM, Garrido S, Raimundo J. Microplastic distribution in different tissues of small pelagic fish of the Northeast Atlantic ocean. Sci Total Environ. 2023;901:166050.

Article  CAS  PubMed  Google Scholar 

Kosuth M, Mason SA, Wattenberg EV. Anthropogenic contamination of tap water, beer, and sea salt. PLoS ONE. 2018;13:e0194970.

Article  PubMed  PubMed Central  Google Scholar 

Liebezeit G, Liebezeit E. Synthetic particles as contaminants in German beers. Food Addit Contam Part Chem Anal Control Expo Risk Assess. 2014;31:1574–8.

Article  CAS  Google Scholar 

Danopoulos E, Jenner LC, Twiddy M, Rotchell JM. Microplastic contamination of seafood intended for human consumption: A systematic review and Meta-Analysis. Environ Health Perspect. 2020;128(12):126002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Landrigan PJ, Raps H, Cropper M, Bald C, Brunner M, Canonizado EM, Charles D, Chiles TC, Donohue MJ, Enck J, Fenichel P, Fleming LE, Ferrier-Pages C, Fordham R, Gozt A, Griffin C, Hahn ME, Haryanto B, Hixson R, Ianelli H, James BD, Kumar P, Laborde A, Law KL, Martin K, Mu J, Mulders Y, Mustapha A, Niu J, Pahl S, Park Y, Pedrotti ML, Pitt JA, Ruchirawat M, Seewoo BJ, Spring M, Stegeman JJ, Suk W, Symeonides C, Takada H, Thompson RC, Vicini A, Wang Z, Whitman E, Wirth D, Wolff M, Yousuf AK, Dunlop S. The Minderoo-Monaco commission on plastics and human health. Ann Glob Health. 2023;89(1):23.

Article  PubMed  PubMed Central  Google Scholar 

Bermúdez JR, Swarzenski PW. A microplastic size classification scheme aligned with universal plankton survey methods. MethodsX. 2021;8:101516.

Article  PubMed  PubMed Central  Google Scholar 

Tanaka K, Takada H. Microplastic fragments and microbeads in digestive tracts of planktivorous fish from urban coastal waters. Sci Rep. 2016;6:34351.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greven AC, Merk T, Karagöz F, Mohr K, Klapper M, Jovanović B, Palić D. Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of Fathead minnow (Pimephales promelas). Environ Toxicol Chem. 2016;35(12):3093–100.

Article  CAS  PubMed  Google Scholar 

Zhu X, Peng L, Song E, Song Y. Polystyrene nanoplastics induce neutrophil extracellular traps in mice neutrophils. Chem Res Toxicol. 2022;35(3):378–82.

Article  CAS  PubMed  Google Scholar 

Cole M, Liddle C, Consolandi G, Drago C, Hird C, Lindeque PK, Galloway TS. Microplastics, microfibres and nanoplastics cause variable sub-lethal responses in mussels (Mytilus spp). Mar Pollut Bull. 2020;160:111552.

Article  CAS  PubMed  Google Scholar 

Vlacil AK, Bänfer S, Jacob R, Trippel N, Kuzu I, Schieffer B, Grote K. Polystyrene microplastic particles induce endothelial activation. PLoS ONE. 2021;16(11):e0260181.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhao X, Tang H, Wang Z, Ge X, Hu S, Li X, Guo S, Liu R. The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules. Environ Pollut. 2024;355:124239.

Article  CAS  PubMed  Google Scholar 

Wang L, Pei W, Li J, Feng Y, Gao X, Jiang P, Wu Q, Li L. Microplastics induced apoptosis in macrophages by promoting ROS generation and altering metabolic profiles. Ecotoxicol Environ Saf. 2024;271:115970.

Article  CAS  PubMed  Google Scholar 

Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer. 1980;26(2):171–6.

Article  CAS  PubMed  Google Scholar 

Sorensen M, Lippuner C, Kaiser T, Misslitz A, Aebischer T, Bumann D. Rapidly maturing red fluorescent protein variants with strongly enhanced brightness in bacteria. FEBS Lett. 2003;552:110–4.

Article  CAS  PubMed  Google Scholar 

Ribes S, Ebert S, Czesnik D, Regen T, Zeug A, Bukowski S, Mildner A, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R. Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells. Infect Immun. 2009;77(1):557–64. https://doi.org/10.1128/IAI.00903-08.

Article  CAS  PubMed  Google Scholar 

Seele J, Heinen KS, Meier V, Ballüer M, Liedtke E, Djukic M, Eiffert H, Nau R. Decreased phagocytosis and intracellular killing of Bacteria in leukocytes of geriatric patients with clostridioides difficile infections. Gerontology. 2024;70(11):1131–6. https://doi.org/10.1159/000541244.

Article  CAS  PubMed  Google Scholar 

Merkley SD, Moss HC, Goodfellow SM, Ling CL, Meyer-Hagen JL, Weaver J, Campen MJ, Castillo EF. Polystyrene microplastics induce an immunometabolic active state in macrophages. Cell Biol Toxicol. 2022;38(1):31–41.

Article  CAS  PubMed  Google Scholar 

Adler MY, Issoual I, Rückert M, Deloch L, Meier C, Tschernig T, Alexiou C, Pfister F, Ramsperger AF, Laforsch C, Gaipl US, Jüngert K, Paulsen F. Effect of micro- and nanoplastic particles on human macrophages. J Hazard Mater. 2024;471:134253.

Article  CAS  PubMed  Google Scholar 

Prietl B, Meindl C, Roblegg E, Pieber TR, Lanzer G, Fröhlich E. Nano-sized and micro-sized polystyrene particles affect phagocyte function. Cell Biol Toxicol. 2014;30:1–16.

Article  CAS  PubMed  Google Scholar 

Thomas SA, Yong HM, Rule AM, Gour N, Lajoie S. Air pollution drives macrophage senescence through a Phagolysosome-15-Lipoxygenase pathway. Immunohorizons. 2024;8:307–16. https://doi.org/10.4049/immunohorizons.2300096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raymond MH, Davidson AJ, Shen Y, Tudor DR, Lucas CD, Morioka S, Perry JSA, Krapivkina J, Perrais D, Schumacher LJ, Campbell RE, Wood W, Ravichandran KS. Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo. Science. 2022;375(6585):1182–7. https://doi.org/10.1126/science.abl4430.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao M, Luo X, Wu K, He X. Targeting lysosomes in human disease: from basic research to clinical applications. Signal Transduct Target Ther. 2021;6(1):379. https://doi.org/10.1038/s41392-021-00778-y.

Article  CAS