Predictors of mortality in sepsis patients with Acinetobacter baumannii and Klebsiella pneumoniae bacteremia—ScienceDirect [Internet]. [cited 2025 12];https://www.sciencedirect.com/science/article/pii/S2213398425001794.
Li W, Sun G, Yu Y, Li N, Chen M, Jin R, et al. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis. 2014;58:225–32. https://doi.org/10.1093/cid/cit675.
Article CAS PubMed Google Scholar
Vandhana V, Saralaya KV, Bhat S, Shenoy Mulki S, Bhat AK. Characterization of hypervirulent Klebsiella pneumoniae (Hv-Kp): correlation of virulence with antimicrobial susceptibility. Int J Microbiol. 2022;2022:4532707. https://doi.org/10.1155/2022/4532707.
Article CAS PubMed PubMed Central Google Scholar
Nagendra D, Chaudhuri S, Gupta N, Shanbhag V, Eshwara VK, Rao S, et al. Prevalence, risk factors, and clinical outcomes of hypervirulent Klebsiella pneumoniae strains among Klebsiella pneumoniae infections: a systematic review and meta-analysis. Indian J Crit Care Med. 2025;29:370–93. https://doi.org/10.5005/jp-journals-10071-24957.
Article CAS PubMed PubMed Central Google Scholar
Nagendra D, R N, Shanbhag V, Eshwara VK, Ramamoorthi K, Priya P, et al. Incidental detection of hypervirulent Klebsiella pneumoniae liver abscess with systemic and cardiac complications in an elderly diabetic woman. Radiol Case Rep. 2025;1:4674–8. https://doi.org/10.1016/j.radcr.2025.06.033.
Emergence of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates harboring blaKPC−2 and iucA from a tertiary teaching hospital in Western China | BMC Infectious Diseases | Full Text [Internet]. [cited 2025 12];https://bmcinfectdis.biomedcentral.com/articles. https://doi.org/10.1186/s12879-025-11241-6.
Huang Y, Li J, Wang Q, Tang K, Cai X, Li C. Detection of carbapenem-resistant hypervirulent Klebsiella pneumoniae ST11-K64 co-producing NDM-1 and KPC-2 in a tertiary hospital in Wuhan. J Hosp Infect. 2023;131:70–80. https://doi.org/10.1016/j.jhin.2022.09.014.
Article CAS PubMed Google Scholar
Liu Y, Wang Z, Jian Z, Liu P, Li Y, Qin F, et al. Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae. BMC Microbiol. 2025;25:376. https://doi.org/10.1186/s12866-025-04096-z.
Article CAS PubMed PubMed Central Google Scholar
Guo M, Gao B, Su J, Zeng Y, Cui Z, Liu H, et al. Phenotypic and genetic characterization of hypervirulent Klebsiella pneumoniae in patients with liver abscess and ventilator-associated pneumonia. BMC Microbiol. 2023;23(1):338. https://doi.org/10.1186/s12866-023-03022-5.
Article CAS PubMed PubMed Central Google Scholar
Antimicrobial resistance, Hypervirulent Klebsiella pneumoniae—global situation [Internet]. [cited 2025 12];https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON527.
Guo Y, Wang S, Zhan L, Jin Y, Duan J, Hao Z, et al. Microbiological and clinical characteristics of hypermucoviscous Klebsiella pneumoniae isolates associated with invasive infections in China. Front Cell Infect Microbiol. 2017. https://doi.org/10.3389/fcimb.2017.00024/full10.3389/fcimb.2017.00024.
Article PubMed PubMed Central Google Scholar
Clinical and microbiological characteristics of Klebsiella pneumoniae liver abscess in East China | BMC Infect Dise | Full Text [Internet]. [cited 2025 12];https://bmcinfectdis.biomedcentral.com/articles. https://doi.org/10.1186/s12879-015-0899-7.
Yan Q, Zhou M, Zou M, Liu W-e. Hypervirulent Klebsiella pneumoniae induced ventilator-associated pneumonia in mechanically ventilated patients in China. Eur J Clin Microbiol Infect Dis. 2016;35:387–96. https://doi.org/10.1007/s10096-015-2551-2.
Article CAS PubMed Google Scholar
Zhang Y, Zhao C, Wang Q, Wang X, Chen H, Li H, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. 2016;60:6115–20. https://doi.org/10.1128/AAC.01127-16.
Article CAS PubMed PubMed Central Google Scholar
Full article: Clinical and microbiological characteristics of endogenous Klebsiella pneumoniae endophthalmitis in a tertiary hospital in Shanghai, China [Internet]. [cited 2025 12];https://www.tandfonline.com/doi/full/. https://doi.org/10.1080/09273948.2022.2161398.
Zhuo X, Lei Z, Pu D, Wu Y, Zhao J, Cao B. Hypervirulent Klebsiella pneumoniae have better clinical outcomes than classical Klebsiella pneumoniae for lower respiratory tract infection patients. BMC Microbiol. 2025;25:40. https://doi.org/10.1186/s12866-024-03726-2.
Article CAS PubMed PubMed Central Google Scholar
The molecular characteristics, clinical manifestations, and risk factors of hypervirulent Klebsiella pneumoniae infections in a large teaching hospital in southwest China—PubMed [Internet]. [cited 2025 12];https://pubmed.ncbi.nlm.nih.gov/34742892/.
Ye M, Tu J, Jiang J, Bi Y, You W, Zhang Y, et al. Clinical and genomic analysis of liver abscess-causing Klebsiella pneumoniae identifies new liver abscess-associated virulence genes. Front Cell Infect Microbiol. 2016;6:165. https://doi.org/10.3389/fcimb.2016.00165.
Article CAS PubMed PubMed Central Google Scholar
Lin Y-T, Cheng Y-H, Chuang C, Chou S-H, Liu W-H, Huang C-H, et al. Molecular and clinical characterization of multidrug-resistant and hypervirulent Klebsiella pneumoniae strains from liver abscess in Taiwan. Antimicrob Agents Chemother. 2020;64:e00174-20. https://doi.org/10.1128/AAC.00174-20.
Article PubMed PubMed Central Google Scholar
PROSPERO [Internet]. [cited 2025 12];https://www.crd.york.ac.uk/prospero/.
JBI Critical Appraisal Tools | JBI [Internet]. [cited 2025 12];https://jbi.global/critical-appraisal-tools.
Journal of Medical Internet Research—MetaAnalysisOnline.com: Web-based tool for the rapid meta-analysis of clinical and epidemiological studies [Internet]. [cited 2025 12];https://www.jmir.org/2025/1/e64016/.
Yu W-L, Ko W-C, Cheng K-C, Lee H-C, Ke D-S, Lee C-C, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 2006;42:1351–8. https://doi.org/10.1086/503420.
Article CAS PubMed Google Scholar
Yu W-L, Lee M-F, Chen C-C, Tang H-J, Ho C-H, Chuang Y-C. Impacts of hypervirulence determinants on clinical features and outcomes of bacteremia caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Microb Drug Resist. 2017;23:376–83. https://doi.org/10.1089/mdr.2016.0018.
Article CAS PubMed Google Scholar
Wu H, Li D, Zhou H, Sun Y, Guo L, Shen D. Bacteremia and other body site infection caused by hypervirulent and classic Klebsiella pneumoniae. Microb Pathog. 2017;104:254–62. https://doi.org/10.1016/j.micpath.2017.01.049.
Jin M, Jia T, Liu X, Yang M, Zhang N, Chen J, et al. Clinical and genomic analysis of hypermucoviscous Klebsiella pneumoniae isolates: identification of new hypermucoviscosity associated genes. Front Cell Infect Microbiol. 2022;12:1063406. https://doi.org/10.3389/fcimb.2022.1063406.
Article CAS PubMed Google Scholar
Kim S-H, Jeon C-H, Kim H-T, Wi YM. Clinical characteristics and manifestations in patients with hypermucoviscous Klebsiella pneumoniae bacteremia from extra-hepatobiliary tract infection. Infection. 2023;51:689–96. https://doi.org/10.1007/s15010-022-01940-6.
Article CAS PubMed Google Scholar
Tang Y, Liu H, Zhao J, Yi M, Yuan Y, Xia Y. Clinical and microbiological prognostic factors of in-hospital mortality caused by hypervirulent Klebsiella pneumoniae infections: a retrospective study in a tertiary hospital in Southwestern China. Infect Drug Resist. 2020;13:3739–49. https://doi.org/10.2147/IDR.S276642.
Article CAS PubMed PubMed Central Google Scholar
Jung SW, Chae HJ, Park YJ, Yu JK, Kim SY, Lee HK, et al. Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea. Epidemiol Infect. 2013;141:334–40. https://doi.org/10.1017/S0950268812000933.
Article CAS PubMed Google Scholar
Yang F, Wang L, Zhao Q, Wu J, Jiang L, Sheng L, et al. Epidemiological features of Klebsiella pneumoniae infection in the hepatobiliary system of patients in Yantai, China, based on clinical and genetic analyses. Infect Drug Resist. 2022;15:3427–36. https://doi.org/10.2147/IDR.S369988.
Article PubMed PubMed Central Google Scholar
Sheng Z, Li J, Chen T, Zhu Y, Yu X, He X, et al. Clinical and microbiological characteristics of Klebsiella pneumoniae bloodstream infection in a Chinese Hospital: hypervirulent and multiclonal. Infect Drug Resist. 2022;26(15):3981–90. https://doi.org/10.2147/IDR.S371477.
Liu C, Guo J. Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob. 2019;18(1):4. https://doi.org/10.1186/s12941-018-0302-9.
Article PubMed PubMed Central Google Scholar
Liu YM, Li BB, Zhang YY, Zhang W, Shen H, Li H, e
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