Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/65973

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v63i06.13729Title: Orlistat mitigates nitrosative stress and enhances paraoxonase-1 activity in serum and tissues of induced obese ratsAuthors: KILINÇ, Sevtap
ÖLÇÜOĞLU, Rukiye
YÝÐÝT, Ayþe ArzuKeywords: Orlistat;Obesity;Nitrosative stress;Paraoxonase enzyme activityIssue Date: Jun-2025Publisher: NIScPR-CSIR, IndiaAbstract: This study examined the effects of orlistat, an anti-obesity medication, on nitrosative stress and paraoxonase-1 (PON-1) enzyme activity in various tissues of rats with experimentally induced obesity. A total of 24 Wistar albino rats were divided into three groups: control, obese, and obese treated with orlistat (ORL). The ORL group received oral doses of 10 mg/kg/day for six weeks following an eight-week high-fat diet. During the study, body weights were monitored weekly, and various biochemical markers, including TNF-alpha, IL-1 beta, nitric oxide, nitrotyrosine, PON-1 enzyme activity, urea, creatinine, lactate dehydrogenase, and creatine kinase, were measured after the rats were sacrificed. The ORL group had significantly lower body weights compared to the obese group (P Page(s): 473-481ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.63(06) [June 2025]

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