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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v63i06.14546Title: Noni fruit juice reverses the adverse effects of 3-Methyl-4-Nitrophenol in rat spleenAuthors: ESENER, Osman Behzat Burak
YİĞİT, Funda
GÜREVÝN, Ebru GÜREL
SÖNMEZ, Kývýlcým
YILMAZER, Nadim
AKTA, Abit
DAÐLIOÐLU, Suzan
YERLÝ, Ozan
DÖLEK, Mehmet Sefa
ARMUTAK, Elif İlkayKeywords: Diesel exhaust particles;Pesticide;Morinda citrifolia;Plasma cell;Rat;Spleen indexIssue Date: Jun-2025Publisher: NIScPR-CSIR, IndiaAbstract: Noni plant is recognized for its antioxidant properties and broad therapeutic effects. 3-Methyl-4-Nitrophenol (PNMC) poses toxic effects on various organs. This study aimed to investigate the effects of PNMC, a substance to which both animals and humans are exposed through diesel exhaust particles and widely used pesticide fenitrothion, on the number of plasma cells in the spleen and also whether Noni could alleviate PNMC-induced spleen damage in rats by assessing spleen index, plasma cell counts, and levels of TNF-á and iNOS. Eight rat groups were treated with different doses of PNMC, either alone or combined with Noni, or only Noni, or vehicle (PBS with 0.05% Tween 80, s.c.) for five days. In histological analysis, plasma cells were counted in methyl green-pyronin stained sections, and TNF-á and iNOS levels were assessed immunohistochemically. PNMC exposure significantly reduced (P Page(s): 465-472ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.63(06) [June 2025]

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