Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/67110

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v63i11.19432Title: Protective role of intravenous macelignanagainst unilateral hind limb ischemia-reperfusion injury in a murine modelAuthors: Enver, Levent
Coskun Sungur, Elif
Demir Benli, Emre
Eyeoğlu, ÖzgeKeywords: Macelignan;Anwuligan;Myristica fragrans;nutmeg;acute hind limb ischemia-reperfusion injuryIssue Date: Nov-2025Publisher: NIScPR - CSIRAbstract: Ischemia-reperfusion injury (I/RI) is a complex pathological process in which tissue damage caused by oxygen deprivation is further aggravated upon reoxygenation. This study aimed to investigate the protective effects and underlying mechanisms of macelignan in an experimental rat model of unilateral hind limb I/RI. Rats were divided into five experimental groups: control, sham, I/RI, and two treatment groups receiving intravenous macelignan either before ischemia (M1) or after ischemia (M2). Ischemia was induced by clamping the unilateral femoral artery for 3 hours, followed by a 3-hour reperfusion period. Macelignan was administered intravenously at a dose of 15 mg/kg: 60 minutes before ischemia in the M1 group and at the onset of reperfusion in the M2 group. Blood and tissue samples were collected for biochemical and histopathological analyses.Significant differences were observed among the groups in serum levels of alanine aminotransferase, creatinine, lactate dehydrogenase, and creatine phosphokinase-3 (PPage(s): 893-900ISSN: 0975-1009 (Online) ; 0019-5189 (Print)Appears in Collections:IJEB Vol.63(11) [November 2025]

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.