Opioids in Critically Ill Acute Myocardial Infarction Patients: A Retrospective Analysis of the MIMIC-IV Database

Hermiz C, Sedhai YR. Angina. StatPearls. Treasure Island (FL) 2024.

Khan MA, Hashim MJ, Mustafa H, et al. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020 Jul 23;12(7):e9349.

PubMed  PubMed Central  Google Scholar 

Padala SK, Lavelle MP, Sidhu MS, et al. Antianginal Therapy for Stable Ischemic Heart Disease: A Contemporary Review. J Cardiovasc Pharmacol Ther. 2017 Nov;22(6):499-510.

Article  CAS  PubMed  Google Scholar 

Jespersen L, Abildstrom SZ, Hvelplund A, et al. Symptoms of angina pectoris increase the probability of disability pension and premature exit from the workforce even in the absence of obstructive coronary artery disease. Eur Heart J. 2013 Nov;34(42):3294-303.

Article  PubMed  Google Scholar 

Alexander KP, Stadnyuk O, Arnold SV, Mark DB, Ohman EM, Anstrom KJ. Assessing Quality of Life and Medical Care in Chronic Angina: An Internet Survey. Interact J Med Res. 2016 Apr 28;5(2):e12.

Article  PubMed  PubMed Central  Google Scholar 

Jespersen L, Abildstrom SZ, Hvelplund A, Prescott E. Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris. Clin Res Cardiol. 2013 Aug;102(8):571-81.

Article  PubMed  Google Scholar 

Choi BG, Rha SW, Yoon SG, Choi CU, Lee MW, Kim SW. Association of Major Adverse Cardiac Events up to 5 Years in Patients With Chest Pain Without Significant Coronary Artery Disease in the Korean Population. J Am Heart Assoc. 2019 Jun 18;8(12):e010541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mesnier J, Ducrocq G, Danchin N, et al. International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study. Circulation. 2021 Aug 17;144(7):512-23.

Article  PubMed  PubMed Central  Google Scholar 

Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-e228.

Article  PubMed  Google Scholar 

Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016 Jan 14;37(3):267-315.

Article  CAS  PubMed  Google Scholar 

Parhar K, Millar V, Zochios V, et al. Clinical outcomes of patients undergoing primary percutaneous coronary intervention for acute myocardial infarction requiring the intensive care unit. J Intensive Care. 2018;6:5.

Article  PubMed  PubMed Central  Google Scholar 

Valley TS, Iwashyna TJ, Cooke CR, et al. Intensive care use and mortality among patients with ST elevation myocardial infarction: retrospective cohort study. BMJ. 2019 Jun 4;365:l1927.

Article  Google Scholar 

Iglesias JF, Valgimigli M, Carbone F, Lauriers N, Masci PG, Degrauwe S. Comparative effects of fentanyl versus morphine on platelet inhibition induced by ticagrelor in patients with ST-segment elevation myocardial infarction: Full results of the PERSEUS randomized trial. Cardiol J. 2022;29(4):591-600.

Article  PubMed  PubMed Central  Google Scholar 

Garin D, Degrauwe S, Carbone F, et al. Differential impact of fentanyl and morphine doses on ticagrelor-induced platelet inhibition in ST-segment elevation myocardial infarction: a subgroup analysis from the PERSEUS randomized trial. Front Cardiovasc Med. 2024;11:1324641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parodi G, Valenti R, Bellandi B, et al. Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study. J Am Coll Cardiol. 2013 Apr 16;61(15):1601-6.

Article  CAS  PubMed  Google Scholar 

Parodi G, Bellandi B, Xanthopoulou I, et al. Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circ Cardiovasc Interv. 2015 Jan;8(1).

Bonin M, Mewton N, Roubille F, et al. Effect and Safety of Morphine Use in Acute Anterior ST-Segment Elevation Myocardial Infarction. J Am Heart Assoc. 2018 Feb 10;7(4).

Meine TJ, Roe MT, Chen AY, et al. Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. Am Heart J. 2005 Jun;149(6):1043-9.

Article  CAS  PubMed  Google Scholar 

Stiermaier T, Schaefer P, Meyer-Saraei R, et al. Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Myocardial and Microvascular Injury in Acute Myocardial Infarction: Insights From the Randomized MonAMI Trial. J Am Heart Assoc. 2021 May 4;10(9):e018881.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson AEW, Bulgarelli L, Shen L, et al. MIMIC-IV, a freely accessible electronic health record dataset. Sci Data. 2023 Jan 3;10(1):1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jager KJ, van Dijk PC, Zoccali C, Dekker FW. The analysis of survival data: the Kaplan-Meier method. Kidney Int. 2008 Sep;74(5):560-5.

Article  PubMed  Google Scholar 

Austin PC. An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivariate Behav Res. 2011 May;46(3):399-424.

Article  PubMed  PubMed Central  Google Scholar 

Sarkar K, Chowdhury R, Dasgupta A. Analysis of Survival Data: Challenges and Algorithm-Based Model Selection. J Clin Diagn Res. 2017 Jun;11(6):LC14-LC20.

PubMed  PubMed Central  Google Scholar 

Degenhardt F, Seifert S, Szymczak S.Evaluation of variable selection methods for random forests and omics data sets. Brief Bioinform. 2019 Mar 22;20(2):492-503

Rouby JJ, Eurin B, Glaser P, et al. Hemodynamic and metabolic effects of morphine in the critically ill. Circulation. 1981 Jul;64(1):53-9.

Article  CAS  PubMed  Google Scholar 

Schultz JE, Gross GJ. Opioids and cardioprotection. Pharmacol Ther. 2001 Feb;89(2):123-37.

Article  CAS  PubMed  Google Scholar 

Palomino J, Echavarria R, Franco-Acevedo A, Moreno-Carranza B, Melo Z. Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review. Medicina (Kaunas). 2019 Aug 23;55(9).

McCarthy CP, Mullins KV, Sidhu SS, Schulman SP, McEvoy JW. The on- and off-target effects of morphine in acute coronary syndrome: A narrative review. Am Heart J. 2016 Jun;176:114-21.

Article  CAS  PubMed  Google Scholar 

Chen A, Ashburn MA. Cardiac Effects of Opioid Therapy. Pain Med. 2015 Oct;16 Suppl 1:S27-31.

Article  PubMed  Google Scholar 

Furtado RHM, Nicolau JC, Guo J, et al. Morphine and Cardiovascular Outcomes Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography. J Am Coll Cardiol. 2020 Jan 28;75(3):289-300.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Wang N, Gu Q. Effects of morphine on P2Y(12) platelet inhibitors in patients with acute myocardial infarction: A meta-analysis. Am J Emerg Med. 2021 Mar;41:219-28.

Article  PubMed  Google Scholar 

Kubica J, Adamski P, Ostrowska M, et al. Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial. Eur Heart J. 2016 Jan 14;37(3):245-52.

Article  CAS  PubMed  Google Scholar 

Krantz MJ, Palmer RB, Haigney MCP. Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Jan 19;77(2):205-23.

Article  CAS  PubMed  Google Scholar 

Eitel I, Wang J, Stiermaier T, et al. Impact of Morphine Treatment on Infarct Size and Reperfusion Injury in Acute Reperfused ST-Elevation Myocardial Infarction. J Clin Med. 2020 Mar 9;9(3).

de Waha S, Eitel I, Desch S, et al. Intravenous morphine administration and reperfusion success in ST-elevation myocardial infarction: insights from cardiac magnetic resonance imaging. Clin Res Cardiol. 2015 Sep;104(9):727-34.

Article  PubMed  Google Scholar 

Duarte GS, Nunes-Ferreira A, Rodrigues FB, et al. Morphine in acute coronary syndrome: systematic review and meta-analysis. BMJ Open. 2019 Mar 15;9(3):e025232.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif