Nolan E, Lindeman GJ, Visvader JE (2023) Deciphering breast cancer: from biology to the clinic. Cell 186:1708–1728. https://doi.org/10.1016/j.cell.2023.01.040

Article  CAS  PubMed  Google Scholar 

Rivenbark AG, O’Connor SM, Coleman WB (2013) Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine. Am J Pathol 183:1113–1124. https://doi.org/10.1016/j.ajpath.2013.08.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farkas AH, Nattinger AB (2023) Breast Cancer screening and prevention. Ann Intern Med 176:ITC161–ITC. https://doi.org/10.7326/AITC202311210

Article  PubMed  Google Scholar 

Patel G, Prince A, Harries M (2024) Advanced Triple-Negative breast Cancer. Semin Oncol Nurs 40:151548. https://doi.org/10.1016/j.soncn.2023.151548

Article  PubMed  Google Scholar 

Capuozzo M, Celotto V, Santorsola M, Fabozzi A, Landi L, Ferrara F, Borzacchiello A, Granata V, Sabbatino F, Savarese G, Cascella M, Perri F, Ottaiano A (2023) Emerging treatment approaches for triple-negative breast cancer. Med Oncol 41:5. https://doi.org/10.1007/s12032-023-02257-6

Article  CAS  PubMed  Google Scholar 

Shakhpazyan N, Mikhaleva L, Bedzhanyan A, Gioeva Z, Sadykhov N, Mikhalev A, Atiakshin D, Buchwalow I, Tiemann M, Orekhov A (2023) Cellular and molecular mechanisms of the tumor stroma in colorectal cancer: insights into disease progression and therapeutic targets. Biomedicines 11. https://doi.org/10.3390/biomedicines11092361

Li JJ, Tsang JY, Tse GM (2021) Tumor microenvironment in breast Cancer-Updates on therapeutic implications and pathologic assessment. Cancers (Basel) 13. https://doi.org/10.3390/cancers13164233

Raz Y, Cohen N, Shani O, Bell RE, Novitskiy SV, Abramovitz L, Levy C, Milyavsky M, Leider-Trejo L, Moses HL, Grisaru D, Erez N (2018) Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. J Exp Med 215:3075–3093. https://doi.org/10.1084/jem.20180818

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chhabra Y, Weeraratna AT (2023) Fibroblasts in cancer: unity in heterogeneity. Cell 186:1580–1609. https://doi.org/10.1016/j.cell.2023.03.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nedaeinia R, Najafgholian S, Salehi R, Goli M, Ranjbar M, Nickho H, Haghjooy Javanmard S, G AF and, Manian M (2024) The role of cancer-associated fibroblasts and Exosomal miRNAs-mediated intercellular communication in the tumor microenvironment and the biology of carcinogenesis: a systematic review. Cell Death Discov 10:380. https://doi.org/10.1038/s41420-024-02146-5

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, Qin M (2023) Extracellular vesicles targeting tumor microenvironment in ovarian cancer. Int J Biol Macromol 252:126300. https://doi.org/10.1016/j.ijbiomac.2023.126300

Article  CAS  PubMed  Google Scholar 

Ingenito F, Roscigno G, Affinito A, Nuzzo S, Scognamiglio I, Quintavalle C, Condorelli G (2019) The role of Exo-miRNAs in cancer: A focus on therapeutic and diagnostic applications. Int J Mol Sci 20. https://doi.org/10.3390/Ijms20194687

Kinoshita T, Yip KW, Spence T, Liu FF (2017) MicroRNAs in extracellular vesicles: potential cancer biomarkers. J Hum Genet 62:67–74. https://doi.org/10.1038/jhg.2016.87

Article  CAS  PubMed  Google Scholar 

Jafari A, Karimabadi K, Rahimi A, Rostaminasab G, Khazaei M, Rezakhani L, Ahmadi Jouybari T (2023) The emerging role of Exosomal MiRNAs as biomarkers for early Cancer detection: A comprehensive literature review. Technol Cancer Res Treat 22:15330338231205999. https://doi.org/10.1177/15330338231205999

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee YS, Dutta A (2009) MicroRNAs in cancer. Annu Rev Pathol 4:199–227. https://doi.org/10.1146/annurev.pathol.4.110807.092222

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin S, Gregory RI (2015) MicroRNA biogenesis pathways in cancer. Nat Rev Cancer 15:321–333. https://doi.org/10.1038/nrc3932

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https://doi.org/10.3389/fendo.2018.00402

Article  PubMed  Google Scholar 

Hussen BM, Hidayat HJ, Salihi A, Sabir DK, Taheri M, Ghafouri-Fard S (2021) MicroRNA: A signature for cancer progression. Biomed Pharmacother 138:111528. https://doi.org/10.1016/j.biopha.2021.111528

Article  CAS  PubMed  Google Scholar 

Khan P, Siddiqui JA, Lakshmanan I, Ganti AK, Salgia R, Jain M, Batra SK, Nasser MW (2021) RNA-based therapies: A cog in the wheel of lung cancer defense. Molecular Cancer 20. ARTN 54. https://doi.org/10.1186/s12943-021-01338-2

Pottoo FH, Iqubal A, Iqubal MK, Salahuddin M, Rahman JU, AlHajri N, Shehadeh M (2021) MiRNAs in the regulation of Cancer immune response: effect of MiRNAs on Cancer immunotherapy. Cancers (Basel) 13. https://doi.org/10.3390/cancers13236145

Chakrabortty A, Patton DJ, Smith BF, Agarwal P (2023) MiRNAs: potential as biomarkers and therapeutic targets for Cancer. Genes (Basel) 14. https://doi.org/10.3390/genes14071375

Garcia-Martin R, Wang G, Brandao BB, Zanotto TM, Shah S, Kumar Patel S, Schilling B, Kahn CR (2022) MicroRNA sequence codes for small extracellular vesicle release and cellular retention. Nature 601:446–451. https://doi.org/10.1038/s41586-021-04234-3

Article  CAS  PubMed  Google Scholar 

Kupec T, Bleilevens A, Iborra S, Najjari L, Wittenborn J, Maurer J, Stickeler E (2022) Stability of Circulating MicroRNAs in serum. PLoS ONE 17:e0268958. https://doi.org/10.1371/journal.pone.0268958

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scognamiglio I, Cocca L, Puoti I, Palma F, Ingenito F, Quintavalle C, Affinito A, Roscigno G, Nuzzo S, Chianese RV, Belli S, Thomas G, Schomann T, Chan A, Stoppelli MP, Condorelli G (2022) Exosomal MicroRNAs synergistically trigger stromal fibroblasts in breast cancer. Mol Ther Nucleic Acids 28:17–31. https://doi.org/10.1016/j.omtn.2022.02.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu D, Di K, Fan B, Wu J, Gu X, Sun Y, Khan A, Li P, Li Z (2022) MicroRNAs in extracellular vesicles: sorting mechanisms, diagnostic value, isolation, and detection technology. Front Bioeng Biotechnol 10:948959. https://doi.org/10.3389/fbioe.2022.948959

Article  PubMed  PubMed Central  Google Scholar 

Alotaibi F (2023) Exosomal MicroRNAs in cancer: potential biomarkers and immunotherapeutic targets for immune checkpoint molecules. Front Genet 14:1052731. https://doi.org/10.3389/fgene.2023.1052731

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aseervatham J (2023) Dynamic role of exosome MicroRNAs in Cancer cell signaling and their emerging role as noninvasive biomarkers. Biology (Basel) 12. https://doi.org/10.3390/biology12050710

Sepulveda F, Mayorga-Lobos C, Guzman K, Duran-Jara E, Lobos-Gonzalez L (2023) EV-miRNA-Mediated intercellular communication in the breast tumor microenvironment. Int J Mol Sci 24. https://doi.org/10.3390/ijms241713085

Jones N, Nonaka T (2024) Circulating MiRNAs as biomarkers for the diagnosis in patients with melanoma: systematic review and meta-analysis. Front Genet 15:1339357. https://doi.org/10.3389/fgene.2024.1339357

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salehi M, Kamali MJ, Arab D, Safaeian N, Ashuori Z, Maddahi M, Latifi N, Jahromi AM (2024) Exosomal MicroRNAs in regulation of tumor cells resistance to apoptosis. Biochem Biophys Rep 37:101644. https://doi.org/10.1016/j.bbrep.2024.101644

Article  CAS  PubMed  PubMed Central  Google Scholar 

Affinito A, Quintavalle C, Chianese RV, Roscigno G, Fiore D, D’Argenio V, Thomas G, Savarese A, Ingenito F, Cocca L, Nuzzo S, Berezovski MV, Stoppelli MP, Condorelli G (2024) MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p. Cell Death Discov 10:140. https://doi.org/10.1038/s41420-024-01910-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Donnarumma E, Fiore D, Nappa M, Roscigno G, Adamo A, Iaboni M, Russo V, Affinito A, Puoti I, Quintavalle C, Rienzo A, Piscuoglio S, Thomas R, Condorelli G (2017) Cancer-associated fibroblasts release Exosomal MicroRNAs that dictate an aggressive phenotype in breast cancer. Oncotarget 8:19592–19608. https://doi.org/10.18632/oncotarget.14752

Article  PubMed  PubMed Central