Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature 361(6410):315–325. https://doi.org/10.1038/361315a0

Article  CAS  PubMed  Google Scholar 

Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1(1):11–21. https://doi.org/10.1038/35036035

Article  CAS  PubMed  Google Scholar 

Azumaya CM, Linton EA, Risener CJ, Nakagawa T, Karakas E (2020) Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. J Biol Chem 295(6):1743–1753. https://doi.org/10.1074/jbc.RA119.011570

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paknejad N, Sapuru V, Hite RK (2023) Structural Titration reveals Ca(2+)-dependent conformational landscape of the IP(3) receptor. Nat Commun 14(1):6897. https://doi.org/10.1038/s41467-023-42707-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bezprozvanny I, Watras J, Ehrlich BE (1991) Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from Endoplasmic reticulum of cerebellum. Nature 351(6329):751–754. https://doi.org/10.1038/351751a0

Article  CAS  PubMed  Google Scholar 

Foskett JK, White C, Cheung KH, Mak DO (2007) Inositol trisphosphate receptor Ca2 + release channels. Physiol Rev 87(2):593–658. https://doi.org/10.1152/physrev.00035.2006

Article  CAS  PubMed  Google Scholar 

Paknejad N, Hite RK (2018) Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP(3). Nat Struct Mol Biol 25(8):660–668. https://doi.org/10.1038/s41594-018-0089-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmitz EA, Takahashi H, Karakas E (2022) Structural basis for activation and gating of IP(3) receptors. Nat Commun 13(1):1408. https://doi.org/10.1038/s41467-022-29073-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arige V, Terry LE, Wagner LE 2nd, Malik S, Baker MR, Fan G et al (2022) Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A 119(39):e2209267119. https://doi.org/10.1073/pnas.2209267119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arige V, MacLean DM, Yule DI (2024) Inositol 1,4,5-Trisphosphate receptor mutations associated with human disease: insights into receptor function and dysfunction. Annu Rev Physiol. https://doi.org/10.1146/annurev-physiol-022724-105627

Article  Google Scholar 

Mak DO, McBride S, Foskett JK (1999) ATP regulation of type 1 inositol 1,4,5-trisphosphate receptor channel gating by allosteric tuning of Ca(2+) activation. J Biol Chem 274(32):22231–22237. https://doi.org/10.1074/jbc.274.32.22231

Article  CAS  PubMed  Google Scholar 

Mak DO, McBride S, Foskett JK (2001) ATP regulation of Recombinant type 3 inositol 1,4,5-trisphosphate receptor gating. J Gen Physiol 117(5):447–456. https://doi.org/10.1085/jgp.117.5.447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Betzenhauser MJ, Yule DI (2010) Regulation of inositol 1,4,5-trisphosphate receptors by phosphorylation and adenine nucleotides. Curr Top Membr 66:273–298. https://doi.org/10.1016/S1063-5823(10)66012-7

Article  CAS  PubMed  Google Scholar 

Arige V, Wagner LE 2nd, Malik S, Baker MR, Fan G, Serysheva II et al (2025) Functional investigation of a putative calcium-binding site involved in the Inhibition of inositol 1,4,5-trisphosphate receptor activity. J Biol Chem 301(3):108302. https://doi.org/10.1016/j.jbc.2025.108302

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan J, Whitten AE, Jeffries CM, Bosanac I, Mal TK, Ito J et al (2007) Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor. J Mol Biol 373(5):1269–1280. https://doi.org/10.1016/j.jmb.2007.08.057

Article  CAS  PubMed  Google Scholar 

Chandran A, Chee X, Prole DL, Rahman T (2019) Exploration of inositol 1,4,5-trisphosphate (IP(3)) regulated dynamics of N-terminal domain of IP(3) receptor reveals early phase molecular events during receptor activation. Sci Rep 9(1):2454. https://doi.org/10.1038/s41598-019-39301-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ et al (2009) Synthetic partial agonists reveal key steps in IP3 receptor activation. Nat Chem Biol 5(9):631–639. https://doi.org/10.1038/nchembio.195

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Yan F, Miao Q, Meng Y, Wen L, Jiang Q et al (2019) Self-binding peptides: Binding-upon-folding versus folding-upon-binding. J Theor Biol 469:25–34. https://doi.org/10.1016/j.jtbi.2019.02.014

Article  CAS  PubMed  Google Scholar 

Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK et al (2002) Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420(6916):696–700. https://doi.org/10.1038/nature01268

Article  CAS  PubMed  Google Scholar 

Tao S, Hulpiau P, Wagner LE 2nd, Witschas K, Yule DI, Bultynck G et al (2024) IP3RPEP6, a novel peptide inhibitor of IP(3) receptor channels that does not affect connexin-43 hemichannels. Acta Physiol (Oxf) 240(3):e14086. https://doi.org/10.1111/apha.14086

Article  CAS  PubMed  Google Scholar 

Lamiable A, Thevenet P, Eustache S, Saladin A, Moroy G, Tuffery P (2017) Peptide suboptimal conformation sampling for the prediction of Protein-Peptide interactions. Methods Mol Biol 1561:21–34. https://doi.org/10.1007/978-1-4939-6798-8_3

Article  CAS  PubMed  Google Scholar 

Sherwood MW, Arizono M, Panatier A, Mikoshiba K, Oliet SHR (2021) Astrocytic IP(3)Rs: beyond IP(3)R2. Front Cell Neurosci 15:695817. https://doi.org/10.3389/fncel.2021.695817

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weiss JN (1997) The hill equation revisited: uses and misuses. FASEB J 11(11):835–841

CAS  PubMed  Google Scholar 

Dawson AP (1997) Calcium signalling: how do IP3 receptors work? Curr Biol 7(9):R544–R547. https://doi.org/10.1016/s0960-9822(06)00277-6

Article  CAS  PubMed  Google Scholar 

Marchant JS, Taylor CW (1997) Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2 + safeguards against spontaneous activity. Curr Biol 7(7):510–518. https://doi.org/10.1016/s0960-9822(06)00222-3

Article  CAS  PubMed  Google Scholar 

Swatton JE, Taylor CW (2002) Fast biphasic regulation of type 3 inositol trisphosphate receptors by cytosolic calcium. J Biol Chem 277(20):17571–17579. https://doi.org/10.1074/jbc.M200524200

Article  CAS  PubMed  Google Scholar 

Iwai M, Michikawa T, Bosanac I, Ikura M, Mikoshiba K (2007) Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors. J Biol Chem 282(17):12755–12764. https://doi.org/10.1074/jbc.M609833200

Article  CAS  PubMed